CTGF/Hcs24, a hypertrophic chondrocyte-specific gene product, stimulates proliferation and differentiation, but not hypertrophy of cultured articular chondrocytes

2002 ◽  
Vol 192 (1) ◽  
pp. 55-63 ◽  
Author(s):  
Takashi Nishida ◽  
Satoshi Kubota ◽  
Tohru Nakanishi ◽  
Takuo Kuboki ◽  
Gen Yosimichi ◽  
...  
Keyword(s):  
Gene Product ◽  
Articular Chondrocytes ◽  
Specific Gene ◽  
Hypertrophic Chondrocyte ◽  
Proliferation And Differentiation

CTGF/Hcs24, hypertrophic chondrocyte-specific gene product, interacts with perlecan in regulating the proliferation and differentiation of chondrocytes

2003 ◽  
Vol 196 (2) ◽  
pp. 265-275 ◽  
Author(s):  
Takashi Nishida ◽  
Satoshi Kubota ◽  
Tomohiro Fukunaga ◽  
Seiji Kondo ◽  
Gen Yosimichi ◽  
...  
Keyword(s):  
Gene Product ◽  
Specific Gene ◽  
Hypertrophic Chondrocyte ◽  
Proliferation And Differentiation

scholarly journals Effects of CTGF/Hcs24, a Product of a Hypertrophic Chondrocyte-Specific Gene, on the Proliferation and Differentiation of Chondrocytes in Culture1

Endocrinology ◽  
2000 ◽  
Vol 141 (1) ◽  
pp. 264-273 ◽  
Author(s):  
Tohru Nakanishi ◽  
Takashi Nishida ◽  
Tsuyoshi Shimo ◽  
Kappei Kobayashi ◽  
Toshikazu Kubo ◽  
...  
Keyword(s):  
Specific Gene ◽  
Hypertrophic Chondrocyte ◽  
Proliferation And Differentiation

Involvement of CTGF, a Hypertrophic Chondrocyte-Specific Gene Product, in Tumor Angiogenesis

Oncology ◽  
2001 ◽  
Vol 61 (4) ◽  
pp. 315-322 ◽  
Author(s):  
Tsuyoshi Shimo ◽  
Tohru Nakanishi ◽  
Takashi Nishida ◽  
Masahiro Asano ◽  
Akira Sasaki ◽  
...  
Keyword(s):  
Gene Product ◽  
Tumor Angiogenesis ◽  
Specific Gene ◽  
Hypertrophic Chondrocyte

scholarly journals Yeast repressor alpha 2 binds to its operator cooperatively with yeast protein Mcm1.

1989 ◽  
Vol 9 (11) ◽  
pp. 5228-5230 ◽  
Author(s):  
C A Keleher ◽  
S Passmore ◽  
A D Johnson
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Gene Product ◽  
Strong Evidence ◽  
Regulatory Proteins ◽  
Yeast Cells ◽  
Specific Gene ◽  
Yeast Gene ◽  
Yeast Protein ◽  
Transcriptional Regulatory

To bring about repression of a family fo genes in Saccharomyces cerevisiae called the a-specific genes, two transcriptional regulatory proteins, alpha 2 and GRM (general regulator of matin type), bind cooperatively to an operator found upstream of each a-specific gene. To date, GRM has been defined only biochemically. In this communication we show that the product of a single yeast gene (MCM1) is sufficient to bind cooperatively with alpha 2 to the operator. We also show that antiserum raised against the MCM1 gene product recognizes GRM from yeast cells. These results, in combination with previous observations, provide strong evidence that MCM1 encodes the GRM activity.

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