Involvement of CTGF, a Hypertrophic Chondrocyte-Specific Gene Product, in Tumor Angiogenesis

Oncology ◽  
2001 ◽  
Vol 61 (4) ◽  
pp. 315-322 ◽  
Author(s):  
Tsuyoshi Shimo ◽  
Tohru Nakanishi ◽  
Takashi Nishida ◽  
Masahiro Asano ◽  
Akira Sasaki ◽  
...  
Keyword(s):  
Gene Product ◽  
Tumor Angiogenesis ◽  
Specific Gene ◽  
Hypertrophic Chondrocyte

CTGF/Hcs24, hypertrophic chondrocyte-specific gene product, interacts with perlecan in regulating the proliferation and differentiation of chondrocytes

2003 ◽  
Vol 196 (2) ◽  
pp. 265-275 ◽  
Author(s):  
Takashi Nishida ◽  
Satoshi Kubota ◽  
Tomohiro Fukunaga ◽  
Seiji Kondo ◽  
Gen Yosimichi ◽  
...  
Keyword(s):  
Gene Product ◽  
Specific Gene ◽  
Hypertrophic Chondrocyte ◽  
Proliferation And Differentiation

scholarly journals Yeast repressor alpha 2 binds to its operator cooperatively with yeast protein Mcm1.

1989 ◽  
Vol 9 (11) ◽  
pp. 5228-5230 ◽  
Author(s):  
C A Keleher ◽  
S Passmore ◽  
A D Johnson
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Gene Product ◽  
Strong Evidence ◽  
Regulatory Proteins ◽  
Yeast Cells ◽  
Specific Gene ◽  
Yeast Gene ◽  
Yeast Protein ◽  
Transcriptional Regulatory

To bring about repression of a family fo genes in Saccharomyces cerevisiae called the a-specific genes, two transcriptional regulatory proteins, alpha 2 and GRM (general regulator of matin type), bind cooperatively to an operator found upstream of each a-specific gene. To date, GRM has been defined only biochemically. In this communication we show that the product of a single yeast gene (MCM1) is sufficient to bind cooperatively with alpha 2 to the operator. We also show that antiserum raised against the MCM1 gene product recognizes GRM from yeast cells. These results, in combination with previous observations, provide strong evidence that MCM1 encodes the GRM activity.

scholarly journals A subunit of the dynein regulatory complex in Chlamydomonas is a homologue of a growth arrest–specific gene product

2003 ◽  
Vol 162 (1) ◽  
pp. 47-57 ◽  
Author(s):  
Gerald Rupp ◽  
Mary E. Porter
Keyword(s):  
Gene Product ◽  
Insertional Mutagenesis ◽  
Growth Arrest ◽  
Coiled Coil ◽  
Specific Gene ◽  
Flagellar Motility ◽  
Wide Range ◽  
Motility Mutant ◽  
Regulatory Complex ◽  
Related Proteins

The dynein regulatory complex (DRC) is an important intermediate in the pathway that regulates flagellar motility. To identify subunits of the DRC, we characterized a Chlamydomonas motility mutant obtained by insertional mutagenesis. The pf2-4 mutant displays an altered waveform that results in slow swimming cells. EM analysis reveals defects in DRC structure that can be rescued by reintroduction of the wild-type PF2 gene. Immunolocalization studies show that the PF2 protein is distributed along the length of the axoneme, where it is part of a discrete complex of polypeptides. PF2 is a coiled-coil protein that shares significant homology with a mammalian growth arrest–specific gene product (Gas11/Gas8) and a trypanosome protein known as trypanin. PF2 and its homologues appear to be universal components of motile axonemes that are required for DRC assembly and the regulation of flagellar motility. The expression of Gas8/Gas11 transcripts in a wide range of tissues may also indicate a potential role for PF2-related proteins in other microtubule-based structures.

Esterification of arylhydroxylamines: Evidence for a specific gene product in mutagenesis

1982 ◽  
Vol 108 (3) ◽  
pp. 1362-1367 ◽  
Author(s):  
Elena C. McCoy ◽  
G.David McCoy ◽  
Herbert S. Rosenkranz
Keyword(s):  
Gene Product ◽  
Specific Gene
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