scholarly journals Correlation between the number of melanosomes, tyrosinase mrna levels, and tyrosinase activity in cultured murine melanoma cells in response to various melanogenesis regulatory agents

1995 ◽  
Vol 163 (3) ◽  
pp. 608-614 ◽  
Author(s):  
Hideya Ando ◽  
Akira Itoh ◽  
Yutaka Mishima ◽  
Masamitsu Ichihashi
Keyword(s):  
Melanoma Cells ◽  
Tyrosinase Activity ◽  
Mrna Levels ◽  
Murine Melanoma ◽  
Murine Melanoma Cells

scholarly journals Modulation by Retinoids of mRNA Levels for Nuclear Retinoic Acid Receptors in Murine Melanoma Cells

1990 ◽  
Vol 4 (10) ◽  
pp. 1546-1555 ◽  
Author(s):  
John L. Clifford ◽  
Martin Petkovich ◽  
Pierre Chambon ◽  
Reuben Lotan
Keyword(s):  
Retinoic Acid ◽  
Melanoma Cells ◽  
Retinoic Acid Receptors ◽  
Mrna Levels ◽  
Murine Melanoma ◽  
Murine Melanoma Cells

scholarly journals Synthesis of Resorcinol Derivatives and their Effects on Melanin Production

Cosmetics ◽  
2020 ◽  
Vol 7 (3) ◽  
pp. 55
Author(s):  
Yoshihiro Tokudome ◽  
Tsuyoshi Hoshi ◽  
Sayaka Mori ◽  
Ichiro Hijikuro
Keyword(s):  
Inhibitory Effect ◽  
Melanoma Cells ◽  
Tyrosinase Activity ◽  
Melanin Production ◽  
Skin Whitening ◽  
Alkyl Chains ◽  
Murine Melanoma ◽  
Resorcinol Derivative ◽  
Melanin Contents ◽  
Murine Melanoma Cells

Several resorcinol derivatives were synthesized and their effects on the survival rate of B16 murine melanoma cells, melanin production, and tyrosinase activity were investigated with an aim to evaluate their skin whitening effect. Twelve resorcinol derivatives were synthesized by esterification with three functional groups (L-ascorb-6-yl, ethyl, and glyceryl) linked via four alkyl chains of varying lengths (n = 2–5) at the 4-position. The structures of the 12 resorcinol derivatives were confirmed by Nuclear Magnetic Resonance (NMR). The derivatives were added to B16 murine melanoma cells and the melanin contents in the cells and culture medium were measured. To measure the tyrosinase activity, the substrate L-DOPA was added to a mushroom-derived tyrosinase solution, and the inhibition of the tyrosinase activity was determined. At 10 µM, the resorcinol derivatives did not affect the survival of the B16 murine melanoma cells, but the melanin content was reduced. At 1 µM, the derivatives significantly inhibited the tyrosinase activity in the mushroom-derived tyrosinase solution. A plot of the inhibitory effect on melanin production against the cLogP value for each resorcinol derivative indicated that the highest inhibition occurred at a cLogP value of approximately 2. Therefore, these resorcinol derivatives are expected to serve as effective skin whitening agents.

scholarly journals Effects of protein hydrolysate from chicken feather meal on tyrosinase activity and melanin formation in B16F10 murine melanoma cells

2017 ◽  
Vol 26 (5) ◽  
pp. 1199-1208 ◽  
Author(s):  
Puttaporn Pongkai ◽  
Tanatorn Saisavoey ◽  
Papassara Sangtanoo ◽  
Polkit Sangvanich ◽  
Aphichart Karnchanatat
Keyword(s):  
Protein Hydrolysate ◽  
Melanoma Cells ◽  
Tyrosinase Activity ◽  
Chicken Feather ◽  
Feather Meal ◽  
Murine Melanoma ◽  
Melanin Formation ◽  
Murine Melanoma Cells ◽  
Chicken Feather Meal

scholarly journals Anthocyanin determination in blueberry extracts from various cultivars and their antiproliferative and apoptotic properties in B16-F10 metastatic murine melanoma cells

2013 ◽  
Vol 95 ◽  
pp. 436-444 ◽  
Author(s):  
Andrea Bunea ◽  
Dumitriţa Rugină ◽  
Zoriţa Sconţa ◽  
Raluca M. Pop ◽  
Adela Pintea ◽  
...  
Keyword(s):  
Melanoma Cells ◽  
Murine Melanoma ◽  
Murine Melanoma Cells

Regulation of c-met expression in B16 murine melanoma cells by melanocyte stimulating hormone

1999 ◽  
Vol 112 (5) ◽  
pp. 623-630
Author(s):  
D. Rusciano ◽  
P. Lorenzoni ◽  
M.M. Burger
Keyword(s):  
Melanoma Cells ◽  
Parental Cell ◽  
Melanocortin Receptor ◽  
Parental Cell Line ◽  
Melanocyte Stimulating Hormone ◽  
Murine Melanoma ◽  
The One ◽  
Murine Melanoma Cells ◽  
Stimulating Hormone

B16 murine melanoma cells selected in vivo for enhanced liver metastatic ability (B16-LS9) show on the one hand an increased expression and constitutive activation of the proto-oncogene c-met (the receptor for hepatocyte growth factor/scatter factor), and on the other hand a more differentiated phenotype, when compared to the parental cell line, B16-F1. Following this observation, we have tried to establish whether there is a direct relationship between differentiation and c-met expression in B16 melanoma cells. Treatment of these cells with differentiating agents indicated that c-met expression was strongly induced by melanocyte stimulating hormone, while retinoic acid had almost no influence. c-met induction was triggered by engagement of the melanocortin receptor, cAMP elevation and PKA/PKC(α) activation, as respectively shown by the effects of ACTH, cAMP elevating agents and specific PK inhibitors. Regulation of c-met expression via the melanocortin receptor and cAMP raises the intriguing possibility that autocrine and/or paracrine mechanisms acting in vivo on this circuit might influence (through c-met expression and activation) the metastatic behavior of these tumor cells, which we have shown to be dependent on their c-met expression.

scholarly journals P-Selectin-Mediated Platelet Adhesion Promotes the Metastasis of Murine Melanoma Cells

PLoS ONE ◽  
2014 ◽  
Vol 9 (3) ◽  
pp. e91320 ◽  
Author(s):  
Cui-Ling Qi ◽  
Bo Wei ◽  
Jie Ye ◽  
Yang Yang ◽  
Bin Li ◽  
...  
Keyword(s):  
Platelet Adhesion ◽  
Melanoma Cells ◽  
Murine Melanoma ◽  
Murine Melanoma Cells
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