scholarly journals A Target‐Mediated Drug Disposition (TMDD) Model to Explain Non‐Linear Pharmacokinetics of the 11β‐Hydroxysteroid Dehydrogenase Type 1 Inhibitor SPI‐62 in Healthy Adults

2021 ◽  
Author(s):  
Nan Wu ◽  
David A. Katz ◽  
Guohua An
Keyword(s):  
Drug Disposition ◽  
Hydroxysteroid Dehydrogenase ◽  
Healthy Adults ◽  
Linear Pharmacokinetics ◽  
Target Mediated Drug Disposition ◽  
Non Linear

The role of hepatic 11[b]-hydroxysteroid dehydrogenase type 1 in cholesterol homeostasis

2013 ◽  
pp. 1-1
Author(s):  
Kajal Manwani ◽  
Tak Y Man ◽  
Christopher J Kenyon ◽  
Ruth Andrew ◽  
Karen E Chapman ◽  
...  
Keyword(s):  
Hydroxysteroid Dehydrogenase ◽  
Cholesterol Homeostasis

Macrophage-specific 11b-hydroxysteroid dehydrogenase type 1 deficiency promotes angiogenesis but impairs resolution of K/BxN serum induced arthritis

2013 ◽  
pp. 1-1
Author(s):  
Zhenguang Zhang ◽  
Agnes Coutinho ◽  
Patrick Hadoke ◽  
Donald Salter ◽  
Jonathan Seckl ◽  
...  
Keyword(s):  
Hydroxysteroid Dehydrogenase

Suppression of 11[beta]-hydroxysteroid dehydrogenase type 1 target gene regulation by hypoxia

2016 ◽  
Author(s):  
Bushra Shammout ◽  
Adewonuola Alase ◽  
Miriam Wittmann ◽  
Paul Stewart ◽  
Ana Tiganescu
Keyword(s):  
Gene Regulation ◽  
Target Gene ◽  
Hydroxysteroid Dehydrogenase

scholarly journals Testosterone Stimulates Adipose Tissue 11β-Hydroxysteroid Dehydrogenase Type 1 Expression in a Depot-Specific Manner in Children

2010 ◽  
Vol 95 (7) ◽  
pp. 3300-3308 ◽  
Author(s):  
Lijun Zhu ◽  
Miao Hou ◽  
Bin Sun ◽  
Jonas Burén ◽  
Li Zhang ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Hydroxysteroid Dehydrogenase ◽  
Specific Manner

scholarly journals Estimating drug potency in the competitive target mediated drug disposition (TMDD) system when the endogenous ligand is included.

2021 ◽  
Author(s):  
Begum Alaybeyoglu ◽  
Ho Wa (Jacky) Cheng ◽  
Kshama A. Doshi ◽  
Vishruti Makani ◽  
Andrew M. Stein
Keyword(s):  
Drug Disposition ◽  
Endogenous Ligand ◽  
Drug Potency ◽  
Target Mediated Drug Disposition
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