A comprehensive study to delineate the role of an extracellular vesicle‐associated microRNA‐29a in chronic methamphetamine use disorder

BackgroundMethamphetamine (MA) is one of the most commonly abused illicit psychostimulant drugs and MA use disorder constitutes a universal health concern across the world. Despite many intervention approaches to MA use disorder, the indicator of addiction severity is mainly limited to subjective craving score to drug-related cues, which is influenced by many factors such as social approval and self-masking.AimThe present study investigates whether self-reported craving for drug use in response to MA cues is a reliable indicator for addiction severity in MA users, and then tests the validity of the cue-induced attention bias test in addiction severity assessment.MethodsFifty-two male MA users completed the cue-induced craving test and attention bias task, and were required to report clinical characteristics of addiction severity. For the attention bias test, subjects were required to discriminate the letter superimposed onto MA use-related or neutral scenes. The reaction time delay during MA-use condition relative to neutral condition was used as an index of the attention bias.ResultsThe results showed that 24 of the 52 MA users rated non-zero in cue-induced craving test, and they showed a significant attention bias to drug-related pictures. However, the other 28 users who rated zero in cue-induced craving evaluation showed a similar attention bias to drug-related cues. In addition, the attention bias to MA use-related cues was significantly and positively correlated with the clinical indexes of addiction severity, but the relationship was absent between subjective craving evaluation and the indexes of addiction severity.ConclusionThese results suggest that attention bias to MA cues may be a more reliable indicator than experiential craving report, especially when subjective craving is measured in the compulsory rehabilitation centre.

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A meta-analysis of the relationship between abstinence and neuropsychological functioning in methamphetamine use disorder.

Neuropsychology ◽

10.1037/neu0000552 ◽

2019 ◽

Vol 33 (5) ◽

pp. 739-753 ◽

Cited By ~ 8

Author(s):

Candice Basterfield ◽

Robert Hester ◽

Stephen C. Bowden

Keyword(s):

Neuropsychological Functioning ◽

Meta Analysis ◽

Methamphetamine Use ◽

Methamphetamine Use Disorder ◽

The Relationship

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The Role of the Internet of Things in Health Care: A Systematic and Comprehensive Study

SSRN Electronic Journal ◽

10.2139/ssrn.3690815 ◽

2020 ◽

Author(s):

Navod Neranjan Thilakarathne ◽

Mohan Krishna Kagita ◽

Thippa Reddy Gadekallu

Keyword(s):

Health Care ◽

Internet Of Things ◽

The Internet ◽

The Internet Of Things ◽

Comprehensive Study

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Dietary Carotenoids in Managing Metabolic Syndrome and Role of PPARs in the Process

Current Nutrition & Food Science ◽

10.2174/1573401315666190619111557 ◽

2020 ◽

Vol 16 (6) ◽

pp. 846-853

Author(s):

Raghunandan Purohith ◽

Nagendra P.M. Nagalingaswamy ◽

Nanjunda S. Shivananju

Keyword(s):

Metabolic Syndrome ◽

Dietary Intervention ◽

Bioactive Constituents ◽

Dietary Antioxidants ◽

Predisposing Factor ◽

Beneficial Effects ◽

Pathological Conditions ◽

Established Relationship ◽

Comprehensive Study

Metabolic syndrome is a collective term that denotes disorder in metabolism, symptoms of which include hyperglycemia, hyperlipidemia, hypertension, and endothelial dysfunction. Diet is a major predisposing factor in the development of metabolic syndrome, and dietary intervention is necessary for both prevention and management. The bioactive constituents of food play a key role in this process. Micronutrients such as vitamins, carotenoids, amino acids, flavonoids, minerals, and aromatic pigment molecules found in fruits, vegetables, spices, and condiments are known to have beneficial effects in preventing and managing metabolic syndrome. There exists a well-established relationship between oxidative stress and major pathological conditions such as inflammation, metabolic syndrome, and cancer. Consequently, dietary antioxidants are implicated in the remediation of these complications. The mechanism of action and targets of dietary antioxidants as well as their effects on related pathways are being extensively studied and elucidated in recent times. This review attempts a comprehensive study of the role of dietary carotenoids in alleviating metabolic syndromewith an emphasis on molecular mechanism-in the light of recent advances.

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639 Co-occuring opioid and methamphetamine use disorder and severe maternal morbidity and mortality in Utah

American Journal of Obstetrics and Gynecology ◽

10.1016/j.ajog.2020.12.663 ◽

2021 ◽

Vol 224 (2) ◽

pp. S401-S402

Author(s):

Marcela Smid ◽

Amanda A. Allshouse ◽

Kristine Campbell ◽

Michelle P. Debbink ◽

Adam G. Gordon ◽

...

Keyword(s):

Maternal Morbidity ◽

Morbidity And Mortality ◽

Severe Maternal Morbidity ◽

Methamphetamine Use ◽

Maternal Morbidity And Mortality ◽

Methamphetamine Use Disorder

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Parkin regulates drug-taking behavior in rat model of methamphetamine use disorder

Translational Psychiatry ◽

10.1038/s41398-021-01387-7 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Akhil Sharma ◽

Arman Harutyunyan ◽

Bernard L. Schneider ◽

Anna Moszczynska

Keyword(s):

Neural Substrates ◽

Genetically Engineered ◽

Wild Type ◽

Therapeutic Approaches ◽

Self Administration ◽

Methamphetamine Use ◽

New Therapeutic Approaches ◽

Extended Access ◽

High Doses ◽

Methamphetamine Use Disorder

AbstractThere is no FDA-approved medication for methamphetamine (METH) use disorder. New therapeutic approaches are needed, especially for people who use METH heavily and are at high risk for overdose. This study used genetically engineered rats to evaluate PARKIN as a potential target for METH use disorder. PARKIN knockout, PARKIN-overexpressing, and wild-type young adult male Long Evans rats were trained to self-administer high doses of METH using an extended-access METH self-administration paradigm. Reinforcing/rewarding properties of METH were assessed by quantifying drug-taking behavior and time spent in a METH-paired environment. PARKIN knockout rats self-administered more METH and spent more time in the METH-paired environment than wild-type rats. Wild-type rats overexpressing PARKIN self-administered less METH and spent less time in the METH-paired environment. PARKIN knockout rats overexpressing PARKIN self-administered less METH during the first half of drug self-administration days than PARKIN-deficient rats. The results indicate that rats with PARKIN excess or PARKIN deficit are useful models for studying neural substrates underlying “resilience” or vulnerability to METH use disorder and identify PARKIN as a novel potential drug target to treat heavy use of METH.

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