Association study of miR‐149, miR‐196a2, and miR‐499a polymorphisms with coronary artery aneurysm of Kawasaki disease in southern Chinese population

Kawasaki disease (KD) is an acute systemic vasculitis syndrome that predominantly affects children younger than 5 years of age, and may causes serious, sometimes life-threatening, cardiac sequela associated with coronary artery aneurysm (CAA). To identify genetic variants that confers a highly increased risk of coronary artery aneurysm-related in Kawasaki disease. In this study, we carried out genome-wide association study (GWAS) in a Korean children population including 102 CAA-related KD cases and 126 controls. Fifteen genetic loci were found to be significantly correlated with KD risk (P<1.0X10(-7)). Our case-control study revealed that rs4236089 C allele in chloride intracellular channel 5 (CLIC5) gene at 6p21.1 was significantly associated with KD patients with CAA (odds ratio (OR)=4.6, P=7.53X10(-7)). These findings suggest that the CLIC5 gene may play a crucial role in CAA development pathway of KD.

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An Angiotensinogen Gene Polymorphism (rs5050) Is Associated with the Risk of Coronary Artery Aneurysm in Southern Chinese Children with Kawasaki Disease

Disease Markers ◽

10.1155/2019/2849695 ◽

2019 ◽

Vol 2019 ◽

pp. 1-7 ◽

Cited By ~ 1

Author(s):

Yunfeng Liu ◽

Lanyan Fu ◽

Lei Pi ◽

Di Che ◽

Yufen Xu ◽

...

Keyword(s):

Coronary Artery ◽

Kawasaki Disease ◽

Gene Polymorphism ◽

Gene Polymorphisms ◽

Coronary Artery Aneurysm ◽

Artery Aneurysm ◽

Chinese Children ◽

Southern Chinese ◽

A Genome ◽

Agt Gene

Background. Kawasaki disease (KD) is an acute vasculitis disease that commonly causes acquired heart disease in children. Coronary artery aneurysm (CAA) is a major complication of KD. However, the pathogenesis of KD remains unclear. The results of a genome-wide association study (GWAS) showed that two functional single-nucleotide polymorphisms (SNPs; rs699A>G and rs5050T>G) in the angiotensinogen (AGT) gene were related to cardiovascular disease susceptibility. The purpose of our study was to estimate the relationship between the two GWAS-identified AGT gene polymorphisms and the risk of CAA in Southern Chinese children with KD. Methods. We genotyped the two AGT gene polymorphisms (rs699A>G and rs5050T>G) in 760 KD cases and 972 healthy controls. We used the odds ratios (ORs) and 95% confidence intervals (CIs) to estimate the degree of the associations. Results. These two AGT gene polymorphisms were not associated with a risk of KD relative to the controls, but after adjusting for sex and age, the carriers of the rs5050G allele with TG/GG vs TT had an adjusted OR=1.56, 95% CI=1.01-2.41, and P=0.044 relative to the carriers of the rs5050TT genotype. The susceptibility to CAA was more predominant in KD patients younger than 12 months old. Conclusions. Our results indicate that the AGT gene polymorphism rs5050T>G may increase the risk of CAA in children with KD, especially those who are younger than 12 months. These results need to be verified by a validation study with a larger sample size.

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Genome-Wide Association Study Identifies Novel Susceptibility Genes Associated with Coronary Artery Aneurysm Formation in Kawasaki Disease

PLoS ONE ◽

10.1371/journal.pone.0154943 ◽

2016 ◽

Vol 11 (5) ◽

pp. e0154943 ◽

Cited By ~ 22

Author(s):

Ho-Chang Kuo ◽

Sung-Chou Li ◽

Mindy Ming-Huey Guo ◽

Ying-Hsien Huang ◽

Hong-Ren Yu ◽

...

Keyword(s):

Coronary Artery ◽

Kawasaki Disease ◽

Association Study ◽

Genome Wide Association Study ◽

Coronary Artery Aneurysm ◽

Artery Aneurysm ◽

Susceptibility Genes ◽

Genome Wide Association ◽

Aneurysm Formation ◽

Genome Wide

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Delayed Coronary Artery Aneurysm in Patients With Kawasaki Disease

AAP Grand Rounds ◽

10.1542/gr.45-1-10 ◽

2021 ◽

Vol 45 (1) ◽

pp. 10-10

Keyword(s):

Coronary Artery ◽

Kawasaki Disease ◽

Coronary Artery Aneurysm ◽

Artery Aneurysm

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Incomplete Kawasaki disease with a giant coronary artery aneurysm; an unexpected finding in an adult male

IJC Heart & Vasculature ◽

10.1016/j.ijcha.2021.100756 ◽

2021 ◽

Vol 34 ◽

pp. 100756

Author(s):

Anu S. Salwan ◽

Assad I.A. Mohammedzein ◽

Masoud A. Alzeerah

Keyword(s):

Coronary Artery ◽

Kawasaki Disease ◽

Adult Male ◽

Coronary Artery Aneurysm ◽

Artery Aneurysm ◽

Unexpected Finding ◽

Incomplete Kawasaki Disease ◽

Giant Coronary Artery Aneurysm

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An update on the epidemiology, length of stay, and cost of Kawasaki disease hospitalisation in the United States

Cardiology in the Young ◽

10.1017/s1047951119000982 ◽

2019 ◽

Vol 29 (06) ◽

pp. 828-832 ◽

Cited By ~ 2

Author(s):

Laxmi V. Ghimire ◽

Fu-Sheng Chou ◽

Narayan B. Mahotra ◽

Sharan P. Sharma

Keyword(s):

Coronary Artery ◽

Kawasaki Disease ◽

Length Of Stay ◽

Coronary Artery Aneurysm ◽

Artery Aneurysm ◽

Developed Countries ◽

The United States ◽

Hospital Charge ◽

Acquired Heart Disease ◽

The Developed Countries

AbstractBackground:Kawasaki disease is an acute vasculitis of childhood and is the leading cause of acquired heart disease in the developed countries.Methods:Data from hospital discharge records were obtained from the National Kids Inpatient Database for years 2009 and 2012. Hospitalisations by months, hospital regions, timing of admission, insurance types, and ethnicity were analysed. Length of stay and total charges were also analysed.Results:There were 10,486 cases of Kawasaki disease from 12,678,005 children hospitalisation. Kawasaki disease was more common between 0 and 5 years old, in male, and in Asian. The January–March quarter had the highest rate compared to the lowest in the July–September quarter (OR=1.62, p < 0.001). Admissions on the weekend had longer length of stay [4.1 days (95 % CI: 3.97–4.31)] as compared to admissions on a weekday [3.72 days (95 % CI: 3.64–3.80), p < 0.001]. Blacks had the longest length of stay and whites had the shortest [4.33 days (95 % CI: 4.12–4.54 days) versus 3.60 days (95 % CI: 3.48–3.72 days), p < 0.001]. Coronary artery aneurysm was identified in 2.7 % of all patients with Kawasaki disease. Children with coronary artery aneurysm were hospitalised longer and had higher hospital charge. Age, admission during weekend, and the presence of coronary artery aneurysm had significant effect on the length of stay.Conclusions:This report provides the most updated epidemiological information on Kawasaki disease hospitalisation. Age, admissions during weekend, and the presence of coronary artery aneurysm are significant contributors to the length of stay.

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