The Use of 2-Chloro-4H-4-oxo-pyrido[1,2-a]pyrimidine as a Building Block in the Synthesis of Some New Heterocyclic Compounds

2013 ◽  
Vol 50 (6) ◽  
pp. 1351-1356 ◽  
Author(s):  
Doria S. Badawy ◽  
Noha M. Awad ◽  
Ebrahim Abdel-Galil
Keyword(s):  
Building Block ◽  
Heterocyclic Compounds

The chemistry of 4-(dicyanomethylene)-3-methyl-l-phenyl-2-pyrazoline-5- ones as a privileged scaffold in synthesis of heterocycles

2020 ◽  
Vol 17 ◽  
Author(s):  
Mohsen A.-M. Gomaa ◽  
Huda A. Ali
Keyword(s):  
Building Block ◽  
Heterocyclic Compounds ◽  
Recent Progress ◽  
Reaction Conditions ◽  
Azacrown Ethers ◽  
Wide Range ◽  
Privileged Scaffold ◽  
Number Of Publications ◽  
Near Future

Background : The reactivity of 4-(dicyanomethylene)-3-methyl-l-phenyl-2-pyrazoline-5-one DCNP 1 and its derivatives makes it valuable as a building block for the synthesis of heterocyclic compounds like pyrazolo-imidazoles, - thiazoles, spiropyridines, spiropyrroles, spiropyrans and others. As a number of publications have reported on the reactivity of DCNP and its derivatives, we compiled some features of this interesting molecule. Objective: This article aims to review the preparation of DCNP, its reactivity and application in heterocyclic and dyes synthesis. Conclusion: In this review we have provided an overview of recent progress in the chemistry of DCNP and its significance in synthesis of various classes of heterocyclic compounds and dyes. The unique reactivity of DCNP offers unprecedentedly mild reaction conditions for the generation of versatile cynomethylene dyes from a wide range of precursors including amines, α-aminocarboxylic acids, their esters, phenols, malononitriles and azacrown ethers. We anticipate that more innovative transformations involving DCNP will continue to emerge in the near future.

Recent Development in the Chemistry of Bicyclic 6+5 Systems, Part I: Chemistry of Pyrazolo[3,4-b]pyridines

2019 ◽  
Vol 17 (1) ◽  
pp. 2-23
Author(s):  
Moustafa A. Gouda ◽  
Moged A. Berghot ◽  
Ghada E.A. El Ghani ◽  
Abdel-Galil M. Khalil
Keyword(s):  
Building Block ◽  
Heterocyclic Compounds ◽  
Pharmacological Interest

This review describes the synthesis and reactions of substituted pyrazolo[3,4-b] pyridines as a building block for the synthesis of polyfunctionalized heterocyclic compounds with pharmacological interest.

4-Aminocoumarin derivatives: synthesis and applications

2021 ◽  
Author(s):  
Madieh Sadeghpour ◽  
Abolfazl Olyaei ◽  
Alireza Adl
Keyword(s):  
Organic Chemistry ◽  
Organic Synthesis ◽  
Building Block ◽  
Heterocyclic Compounds ◽  
Important Class

4-Aminocoumarins represent an important class of a versatile scaffold in organic synthesis and have been consistently used as a building block in organic chemistry for the synthesis of different heterocyclic compounds.

REVIEW ON THE SYNTHESIS AND POTENTIAL THERAPEUTIC APPLICATIONS OF HETEROCYCLIC PRODUCTS OF 5-AMINO-3-METHYLISOXAZOLE

2021 ◽  
Vol 12 (08) ◽  
pp. 154-172
Author(s):  
Tahira Saleem ◽  
Muhammad Humble Khalid Tareen ◽  
Muhammad Rashid ◽  
Mehwish Nawaz ◽  
Hina Aftab ◽  
...  
Keyword(s):  
Functional Groups ◽  
Building Block ◽  
Heterocyclic Compounds ◽  
Medicinal Chemistry ◽  
Drug Molecule ◽  
Therapeutic Applications ◽  
Biological Actions

In general, heterocyclic compounds have evoked interest and concern because of their fundamental role in biological profiles and biological actions in nature. Now, most of the lead molecules in medicinal chemistry are based on hetero-atoms. In medicinal chemistry- to bring two hetero-atoms to the drug molecule, isoxazoles are interesting functional groups. Isoxazole as a key building block has been widely used and is an important heterocyclic unit.

Quinacetophenone: a simple precursor for synthesis of phenoxazines

2019 ◽  
Vol 43 (37) ◽  
pp. 14952-14960 ◽  
Author(s):  
Saiprasad N. Nunewar ◽  
Bhavana B. Muthyala ◽  
Sowmya Dastari ◽  
Neelima D. Tangellamudi
Keyword(s):  
Building Block ◽  
Heterocyclic Compounds ◽  
Biologically Active

Quinacetophenone is a versatile and easy accessible building block for synthesis of various biologically active heterocyclic compounds.

Thiosemicarbazide Derivatives as Building Block in Synthesis of Target Heterocyclic Compounds with Their Antimicrobial Assessment

2016 ◽  
Vol 54 (2) ◽  
pp. 1391-1395
Author(s):  
Wael S. I. Abou Elmagd ◽  
Magdy M. Hemdan ◽  
Sandy S. Samy ◽  
Ahmed S. A. Youssef
Keyword(s):  
Building Block ◽  
Heterocyclic Compounds ◽  
Thiosemicarbazide Derivatives

scholarly journals Synthesis and Antimicrobial activity of 1-(2-hydroxy-3,5- bis((3-imino-3H-1,2,4-dithiazol-5-yl)amino)phenyl)ethanone

2020 ◽  
Vol 13 (3) ◽  
pp. 310-314
Author(s):  
A.K. Wanjari
Keyword(s):  
Antimicrobial Activity ◽  
Pharmaceutical Industry ◽  
Building Block ◽  
Heterocyclic Compounds ◽  
Drug Research ◽  
Chemical Characterization ◽  
Gram Negative Bacteria ◽  
Active Pharmaceutical Ingredients ◽  
Gram Negative ◽  
Pharmaceutical Ingredients

Heterocyclic compounds are used as a building block with a wide application in pharmaceutical industry, medicinal and drug research. This research paper explore the synthesis and antimicrobial activity of 1-(2-hydroxy-3,5-bis((3-imino-3H-1,2,4-dithiazol-5- yl)amino)phenyl) ethanone. The synthesis of 1-(2-hydroxy-3,5-bis((3-imino-3H-1,2,4- dithiazol-5-yl)amino)phenyl) ethanone carried out by using 4-chlorophenol as a starting material which is well knows as a active pharmaceutical ingredients. The synthesised compound tested for the gram positive and gram negative bacteria. The identification of the synthesized compound has been done by using chemical characterization and spectral data. Keywords : -chlorophenol, thiourea, isothiocynates, 4-chloroacetate, 1-(2-hydroxy-3,5-bis((3- imino-3H-1,2,4-dithiazol-5-yl)amino)phenyl)ethanone.

ChemInform Abstract: 1-(N,N-Dimethylamino)-2-(N-phenylcarbamoyl)-1-buten-3-one as a Building Block for the Synthesis of Heterocyclic Compounds.

ChemInform ◽  
2010 ◽  
Vol 33 (43) ◽  
pp. no-no ◽  
Author(s):  
T. A. Elmaati ◽  
S. Said ◽  
N. A. Elenein ◽  
M. Sofan ◽  
N. Khodeir
Keyword(s):  
Building Block ◽  
Heterocyclic Compounds
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