Recent Development in the Chemistry of Bicyclic 6+5 Systems, Part I: Chemistry of Pyrazolo[3,4-b]pyridines

2019 ◽  
Vol 17 (1) ◽  
pp. 2-23
Author(s):  
Moustafa A. Gouda ◽  
Moged A. Berghot ◽  
Ghada E.A. El Ghani ◽  
Abdel-Galil M. Khalil
Keyword(s):  
Building Block ◽  
Heterocyclic Compounds ◽  
Pharmacological Interest

This review describes the synthesis and reactions of substituted pyrazolo[3,4-b] pyridines as a building block for the synthesis of polyfunctionalized heterocyclic compounds with pharmacological interest.

Recent Development in the Chemistry of Bicyclic 6+5 Systems, Part II: Chemistry of Triazolopyrimidine Derivatives

2020 ◽  
Vol 17 (12) ◽  
pp. 897-925 ◽  
Author(s):  
Moustafa A. Gouda ◽  
Ameen Ali Abu-Hashem ◽  
Hoda Abdel Raouf Hussein ◽  
Ahmed S. Aly
Keyword(s):  
Heterocyclic Compounds ◽  
Building Blocks ◽  
Pharmacological Interest

This review describes the synthesis and reactions of substituted triazolopyrimidines as building blocks toward polyfunctionalized heterocyclic compounds with pharmacological interest.

The chemistry of 4-(dicyanomethylene)-3-methyl-l-phenyl-2-pyrazoline-5- ones as a privileged scaffold in synthesis of heterocycles

2020 ◽  
Vol 17 ◽  
Author(s):  
Mohsen A.-M. Gomaa ◽  
Huda A. Ali
Keyword(s):  
Building Block ◽  
Heterocyclic Compounds ◽  
Recent Progress ◽  
Reaction Conditions ◽  
Azacrown Ethers ◽  
Wide Range ◽  
Privileged Scaffold ◽  
Number Of Publications ◽  
Near Future

Background : The reactivity of 4-(dicyanomethylene)-3-methyl-l-phenyl-2-pyrazoline-5-one DCNP 1 and its derivatives makes it valuable as a building block for the synthesis of heterocyclic compounds like pyrazolo-imidazoles, - thiazoles, spiropyridines, spiropyrroles, spiropyrans and others. As a number of publications have reported on the reactivity of DCNP and its derivatives, we compiled some features of this interesting molecule. Objective: This article aims to review the preparation of DCNP, its reactivity and application in heterocyclic and dyes synthesis. Conclusion: In this review we have provided an overview of recent progress in the chemistry of DCNP and its significance in synthesis of various classes of heterocyclic compounds and dyes. The unique reactivity of DCNP offers unprecedentedly mild reaction conditions for the generation of versatile cynomethylene dyes from a wide range of precursors including amines, α-aminocarboxylic acids, their esters, phenols, malononitriles and azacrown ethers. We anticipate that more innovative transformations involving DCNP will continue to emerge in the near future.

1-Benzyl-4-chloromethylpiperidine: A Building Block in the Synthesis of Compounds of Pharmacological Interest

Synthesis ◽  
2002 ◽  
Vol 2002 (07) ◽  
pp. 911-915 ◽  
Author(s):  
María Isabel Rodríguez-Franco ◽  
María Isabel Fernández-Bachiller
Keyword(s):  
Building Block ◽  
Pharmacological Interest

scholarly journals Synthesis, Characterize and Evaluation of anti-bacterial and anti-fungal activity of thiazines

2019 ◽  
Vol 1 (1) ◽  
pp. 25-35
Author(s):  
Arsalan Sarmad ◽  
Razia Sultana ◽  
B. Syed Salman
Keyword(s):  
Heterocyclic Compounds ◽  
Biological Activities ◽  
Selective Synthesis ◽  
Fungal Activity ◽  
Pharmacological Interest ◽  
Frame Work ◽  
Anti Fungal ◽  
Molecular Frame

1,3 – Thiazines have been applied as useful starting materials in the stereo selective synthesis of compounds of pharmacological interest and they have served as chiral ligants and auxiliaries in enantioselective transformation. The thiazines are of great importance because they act as precursor for the synthesis of Cephalosporins (3,6-dihydro-2H-,1,3-thiazine) and then converted to the thiazine derivatives (an heterocyclic compounds). Therefore, it was thought to combine chalcones moiety to thiazine derivative together in a molecular frame work to see the biological activities, additive effort of these rings towards biological activities like Anti- bacterial and Anti- fungal activities.

4-Aminocoumarin derivatives: synthesis and applications

2021 ◽  
Author(s):  
Madieh Sadeghpour ◽  
Abolfazl Olyaei ◽  
Alireza Adl
Keyword(s):  
Organic Chemistry ◽  
Organic Synthesis ◽  
Building Block ◽  
Heterocyclic Compounds ◽  
Important Class

4-Aminocoumarins represent an important class of a versatile scaffold in organic synthesis and have been consistently used as a building block in organic chemistry for the synthesis of different heterocyclic compounds.

scholarly journals 2-Acetylbenzimidazole: a Valuable Synthon for the Synthesis of Biologically Active Molecules

2020 ◽  
Vol 11 (4) ◽  
pp. 11562-11591
Keyword(s):  
Heterocyclic Compounds ◽  
Heterocyclic System ◽  
Biological Activities ◽  
Biologically Active ◽  
Online Search ◽  
Convenient Synthesis ◽  
Anti Cancer ◽  
Pharmacological Interest ◽  
Main Motive ◽  
Biological Aspects

Benzimidazole is an important moiety from a medicinal chemistry perspective due to its various biological activities such as antimicrobial, anti-cancer, anti-diabetic, anti-Alzheimers, and anti-inflammatory, etc. 2-acetylbenzimidazole is exploited to obtain various heterocyclic compounds of pharmacological interest. This review's main motive is to present the literature on 2-acetylbenzimidazole chemistry and provide valuable and up-to-date information for its applications. The present review is carried out by compiling literature from 1964 to 2020 concerning the synthesis and biological aspects of various heterocyclic compounds derived from 2-acetylbenzimidazole. Literature was collected from various online search engines viz. Google Scholar, PubMed, Science Direct, Core, and Semantic scholar. 2-acetylbenzimidazole has been successfully employed as a synthon to obtain heterocyclic system viz. oxirane, pyrazoline, thiazole, pyrazole, isoxazoline, isoxazole, pyridine, pyrimidine, thiazine, diazepine, and other miscellaneous rings. 2-acetylbenzimidazole has shown promise for the convenient synthesis of various heterocyclic compounds. The reactions can be carried out on various reactive sites of 2-acetylbenzimidazole, which are the carbonyl group and the amino group. This review will help to explore various heterocyclic compounds and particularly in the synthesis of biologically useful compounds.

REVIEW ON THE SYNTHESIS AND POTENTIAL THERAPEUTIC APPLICATIONS OF HETEROCYCLIC PRODUCTS OF 5-AMINO-3-METHYLISOXAZOLE

2021 ◽  
Vol 12 (08) ◽  
pp. 154-172
Author(s):  
Tahira Saleem ◽  
Muhammad Humble Khalid Tareen ◽  
Muhammad Rashid ◽  
Mehwish Nawaz ◽  
Hina Aftab ◽  
...  
Keyword(s):  
Functional Groups ◽  
Building Block ◽  
Heterocyclic Compounds ◽  
Medicinal Chemistry ◽  
Drug Molecule ◽  
Therapeutic Applications ◽  
Biological Actions

In general, heterocyclic compounds have evoked interest and concern because of their fundamental role in biological profiles and biological actions in nature. Now, most of the lead molecules in medicinal chemistry are based on hetero-atoms. In medicinal chemistry- to bring two hetero-atoms to the drug molecule, isoxazoles are interesting functional groups. Isoxazole as a key building block has been widely used and is an important heterocyclic unit.

Quinacetophenone: a simple precursor for synthesis of phenoxazines

2019 ◽  
Vol 43 (37) ◽  
pp. 14952-14960 ◽  
Author(s):  
Saiprasad N. Nunewar ◽  
Bhavana B. Muthyala ◽  
Sowmya Dastari ◽  
Neelima D. Tangellamudi
Keyword(s):  
Building Block ◽  
Heterocyclic Compounds ◽  
Biologically Active

Quinacetophenone is a versatile and easy accessible building block for synthesis of various biologically active heterocyclic compounds.

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