Selective inhibition of antigen-specific T lymphocyte proliferation by acute ethanol exposure: the role of impaired monocyte antigen presentation capacity and mediator production

1993 ◽  
Vol 54 (6) ◽  
pp. 534-544 ◽  
Author(s):  
Gyongyi Szabo ◽  
Bikash Verma ◽  
Donna Catalano
Keyword(s):  
Antigen Presentation ◽  
T Lymphocyte ◽  
Lymphocyte Proliferation ◽  
Selective Inhibition ◽  
Ethanol Exposure ◽  
T Lymphocyte Proliferation ◽  
Acute Ethanol

Role of Heme–Hemopexin in Human T-Lymphocyte Proliferation

1997 ◽  
Vol 232 (2) ◽  
pp. 246-254 ◽  
Author(s):  
Ann Smith ◽  
Jeffrey D. Eskew ◽  
Corina M. Borza ◽  
Michael Pendrak ◽  
Richard C. Hunt
Keyword(s):  
T Lymphocyte ◽  
Lymphocyte Proliferation ◽  
T Lymphocyte Proliferation ◽  
Human T Lymphocyte

scholarly journals The role of low molecular weight thiols in T lymphocyte proliferation and IL-2 secretion

2006 ◽  
Vol 176 (9) ◽  
pp. 5682.3-5682 ◽  
Author(s):  
T. Hadzic ◽  
L. Li ◽  
N. Cheng ◽  
S. A. Walsh ◽  
D. R. Spitz ◽  
...  
Keyword(s):  
Molecular Weight ◽  
T Lymphocyte ◽  
Lymphocyte Proliferation ◽  
Low Molecular Weight ◽  
T Lymphocyte Proliferation

scholarly journals The Role of Low Molecular Weight Thiols in T Lymphocyte Proliferation and IL-2 Secretion

2005 ◽  
Vol 175 (12) ◽  
pp. 7965-7972 ◽  
Author(s):  
Tanja Hadzic ◽  
Ling Li ◽  
Ningli Cheng ◽  
Susan A. Walsh ◽  
Douglas R. Spitz ◽  
...  
Keyword(s):  
Molecular Weight ◽  
T Lymphocyte ◽  
Lymphocyte Proliferation ◽  
Low Molecular Weight ◽  
T Lymphocyte Proliferation

scholarly journals Glycerol-3-phosphate acyltransferase-1 regulates murine T-lymphocyte proliferation and cytokine production

2008 ◽  
Vol 295 (6) ◽  
pp. C1543-C1549 ◽  
Author(s):  
Lauren W. Collison ◽  
Eric J. Murphy ◽  
Christopher A. Jolly
Keyword(s):  
T Lymphocytes ◽  
T Lymphocyte ◽  
Lymphocyte Proliferation ◽  
Membrane Lipid ◽  
Cytokine Secretion ◽  
Prostaglandin E ◽  
Lymphocyte Function ◽  
T Lymphocyte Proliferation ◽  
Induced Apoptosis

We have previously established a correlation between reduced mitochondrial glycerol-3-phosphate acyltransferase-1 (GPAT-1) activity and decreased proliferation in splenic T-lymphocytes from aged rats. To better understand the immunoregulatory role of GPAT-1, we examined T-lymphocyte function in young GPAT-1 knockout (KO) mice. We show that without GPAT-1, T-lymphocyte proliferation is inhibited and activation induced apoptosis is increased. Th-1 (IL-2 and IFN-γ) cytokine secretion is reduced, and Th-2 (IL-4 and IL-10) cytokine secretion is increased. These changes may be due to alterations in membrane lipid composition since we found changes in the relative content of individual phospholipid species. Furthermore, we show increased arachidonate content and subsequent increased prostaglandin E2 secretion, which may inhibit T-lymphocyte proliferation. Taken together, we show a novel link between GPAT-1 and changes in T-lymphocyte function. These data have broad health implications because GPAT-1 suppression has recently been implicated as a new target for preventing insulin sensitivity and hepatic steatosis and we show that immune function may also be affected. Interestingly, the changes in young GPAT-1 KO splenic T-lymphocytes are similar to defects commonly seen in T-lymphocytes from aged rodents, which further underscores the significance of GPAT-1 in T-lymphocyte function.

Sign in / Sign up

Export Citation Format

Share Document