Glucose and hippocampal neuronal excitability: Role of ATP-sensitive potassium channels

2007 ◽  
Vol 85 (7) ◽  
pp. 1468-1477 ◽  
Author(s):  
Chin-Wei Huang ◽  
Chao-Ching Huang ◽  
Juei-Tang Cheng ◽  
Jing-Jane Tsai ◽  
Sheng-Nan Wu
Keyword(s):  
Potassium Channels ◽  
Neuronal Excitability

Serotonin Receptor Heterogeneity and the Role of Potassium Channels in Neuronal Excitability

1991 ◽  
pp. 177-191 ◽  
Author(s):  
J. S. Kelly ◽  
P. Larkman ◽  
N. J. Penington ◽  
D. G. Rainnie ◽  
H. McAllister-Williams ◽  
...  
Keyword(s):  
Potassium Channels ◽  
Serotonin Receptor ◽  
Neuronal Excitability

scholarly journals Dysregulation of Astrocyte–Neuronal Communication in Alzheimer’s Disease

2021 ◽  
Vol 22 (15) ◽  
pp. 7887
Author(s):  
Carmen Nanclares ◽  
Andres Mateo Baraibar ◽  
Alfonso Araque ◽  
Paulo Kofuji
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Synaptic Plasticity ◽  
Neuronal Excitability ◽  
Active Role ◽  
Ionic Homeostasis ◽  
Neuronal Communication ◽  
Structural Support

Recent studies implicate astrocytes in Alzheimer’s disease (AD); however, their role in pathogenesis is poorly understood. Astrocytes have well-established functions in supportive functions such as extracellular ionic homeostasis, structural support, and neurovascular coupling. However, emerging research on astrocytic function in the healthy brain also indicates their role in regulating synaptic plasticity and neuronal excitability via the release of neuroactive substances named gliotransmitters. Here, we review how this “active” role of astrocytes at synapses could contribute to synaptic and neuronal network dysfunction and cognitive impairment in AD.

Role of potassium channels in stretch-promoted atrial natriuretic factor secretion

2009 ◽  
Vol 3 (1) ◽  
pp. 9-18 ◽  
Author(s):  
Tsuneo Ogawa ◽  
Monica Forero ◽  
Patrick G. Burgon ◽  
Mercedes L. Kuroski de Bold ◽  
Tina Georgalis ◽  
...  
Keyword(s):  
Potassium Channels ◽  
Atrial Natriuretic Factor ◽  
Natriuretic Factor ◽  
Factor Secretion ◽  
Atrial Natriuretic

Dopamine Increases the Gain of the Input-Output Response of Rat Prefrontal Pyramidal Neurons

2008 ◽  
Vol 99 (6) ◽  
pp. 2985-2997 ◽  
Author(s):  
Kay Thurley ◽  
Walter Senn ◽  
Hans-Rudolf Lüscher
Keyword(s):  
Working Memory ◽  
Neuronal Excitability ◽  
Pyramidal Neurons ◽  
D1 Receptors ◽  
Input Output ◽  
Prefrontal Cortical ◽  
Noisy Input ◽  
Relationship Of

Dopaminergic modulation of prefrontal cortical activity is known to affect cognitive functions like working memory. Little consensus on the role of dopamine modulation has been achieved, however, in part because quantities directly relating to the neuronal substrate of working memory are difficult to measure. Here we show that dopamine increases the gain of the frequency-current relationship of layer 5 pyramidal neurons in vitro in response to noisy input currents. The gain increase could be attributed to a reduction of the slow afterhyperpolarization by dopamine. Dopamine also increases neuronal excitability by shifting the input-output functions to lower inputs. The modulation of these response properties is mainly mediated by D1 receptors. Integrate-and-fire neurons were fitted to the experimentally recorded input-output functions and recurrently connected in a model network. The gain increase induced by dopamine application facilitated and stabilized persistent activity in this network. The results support the hypothesis that catecholamines increase the neuronal gain and suggest that dopamine improves working memory via gain modulation.

scholarly journals Minoxidil prevents 3,4-methylenedioxymethamphetamine-induced serotonin depletions: role of mitochondrial ATP-sensitive potassium channels, Akt and ERK

2008 ◽  
Vol 104 (4) ◽  
pp. 914-925 ◽  
Author(s):  
Beatriz Goñi-Allo ◽  
Elena Puerta ◽  
María Ramos ◽  
Berta Lasheras ◽  
Joaquín Jordán ◽  
...  
Keyword(s):  
Potassium Channels

Inherited Cardiac Arrhythmia Syndrome: Role of Potassium Channels

2011 ◽  
Vol 3 (1) ◽  
pp. 113-124
Author(s):  
Lia Crotti ◽  
Roberto Insolia ◽  
Peter J. Schwartz
Keyword(s):  
Potassium Channels ◽  
Cardiac Arrhythmia

scholarly journals Acid sensing ion channels regulate neuronal excitability by inhibiting BK potassium channels

2012 ◽  
Vol 426 (4) ◽  
pp. 511-515 ◽  
Author(s):  
Elena Petroff ◽  
Vladislav Snitsarev ◽  
Huiyu Gong ◽  
Francois M. Abboud
Keyword(s):  
Ion Channels ◽  
Potassium Channels ◽  
Neuronal Excitability ◽  
Acid Sensing Ion Channels

Role of leak potassium channels in pain signaling

2015 ◽  
Vol 119 ◽  
pp. 73-79 ◽  
Author(s):  
Xiang-Yao Li ◽  
Hiroki Toyoda
Keyword(s):  
Potassium Channels
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