Increased in vitro glial fibrillary acidic protein expression, telomerase activity, and telomere length after productive human immunodeficiency virus‐1 infection in murine astrocytes

2013 ◽  
Vol 92 (2) ◽  
pp. 267-274 ◽  
Author(s):  
Diego Ojeda ◽  
Juan José López‐Costa ◽  
Mariano Sede ◽  
Ester María López ◽  
María Isabel Berria ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Glial Fibrillary Acidic Protein ◽  
Protein Expression ◽  
Telomere Length ◽  
Telomerase Activity ◽  
Acidic Protein ◽  
Immunodeficiency Virus ◽  
Human Immunodeficiency Virus 1

scholarly journals Novel Human Immunodeficiency Virus (HIV) Inhibitors That Have a Dual Mode of Anti-HIV Action

2003 ◽  
Vol 47 (10) ◽  
pp. 3109-3116 ◽  
Author(s):  
Miguel Stevens ◽  
Christophe Pannecouque ◽  
Erik De Clercq ◽  
Jan Balzarini
Keyword(s):  
Human Immunodeficiency Virus ◽  
Protein Expression ◽  
Viral Protein ◽  
Green Fluorescence Protein Expression ◽  
Wide Range ◽  
Immunodeficiency Virus ◽  
Infected Cells ◽  
Anti Hiv ◽  
Hiv 1

ABSTRACT We have found that novel pyridine oxide derivatives are inhibitors of a wide range of human immunodeficiency virus (HIV) type 1 (HIV-1) and HIV-2 strains in CEM cell cultures. Some of the compounds showed inhibitory activities against recombinant HIV-1 reverse transcriptase (RT), whereas others were totally inactive against this viral protein in vitro. Partial retention of anti-HIV-1 activity against virus strains that contain a variety of mutations characteristic of those for resistance to nonnucleoside RT inhibitors and a lack of inhibitory activity against recombinant HIV-2 RT suggested that these pyridine oxide derivatives possess a mode of antiviral action independent from HIV RT inhibition. Time-of-addition experiments revealed that these pyridine oxide derivatives interact at a postintegration step in the replication cycle of HIV. Furthermore, it was shown that these compounds are active not only in acutely HIV-1-infected cells but also in chronically HIV-infected cells. A dose-dependent inhibition of virus particle release and viral protein expression was observed upon exposure to the pyridine oxide derivatives. Finally, inhibition of HIV-1 long terminal repeat-mediated green fluorescence protein expression in quantitative transactivation bioassays indicated that the additional target of action of the pyridine oxide derivatives may be located at the level of HIV gene expression.

scholarly journals Synergistic neurotoxicity of opioids and human immunodeficiency virus-1 Tat protein in striatal neurons in vitro

Neuroscience ◽  
2001 ◽  
Vol 102 (3) ◽  
pp. 555-563 ◽  
Author(s):  
J.A. Gurwell ◽  
A. Nath ◽  
Q. Sun ◽  
J. Zhang ◽  
K.M. Martin ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Tat Protein ◽  
Striatal Neurons ◽  
Immunodeficiency Virus ◽  
Human Immunodeficiency Virus 1

scholarly journals HIV-1LAI Nef blocks the development of hematopoietic stem/progenitor cells into myeloid-erythroid lineage cells

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Wei Zou ◽  
Juanjuan Xing ◽  
Shijie Zou ◽  
Mei Jiang ◽  
Xinping Chen ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Progenitor Cells ◽  
Cell Loss ◽  
Underlying Mechanism ◽  
Humanized Mice ◽  
Hematopoietic Stem ◽  
Immunodeficiency Virus ◽  
Hiv 1 ◽  
Human Immunodeficiency Virus 1

Abstract Background A variety of hematopoietic abnormalities are commonly seen in human immunodeficiency virus-1 (HIV-1) infected individuals despite antiviral therapy, but the underlying mechanism remains elusive. Nef plays an important role in HIV-1 induced T cell loss and disease progression, but it is not known whether Nef participates in other hematopoietic abnormalities associated with infection. Results In the current study we investigated the influence of HIV-1LAI Nef (LAI Nef) on the development of hematopoietic stem/progenitor cells (HSPCs) into myeloid-erythroid lineage cells, and found that nef expression in HSPCs blocked their differentiation both in vitro and in humanized mice reconstituted with nef-expressing HSPCs. Conclusions Our novel findings demonstrate LAI Nef compromised the development of myeloid-erythroid lineage cells, and therapeutics targeting Nef would be promising in correcting HIV-1 associated hematopoietic abnormalities.

scholarly journals Replication of the human immunodeficiency virus 1 and impaired differentiation of T cells after in vitro infection of bone marrow immature T cells.

1989 ◽  
Vol 83 (2) ◽  
pp. 610-615 ◽  
Author(s):  
Y Lunardi-Iskandar ◽  
M T Nugeyre ◽  
V Georgoulias ◽  
F Barré-Sinoussi ◽  
C Jasmin ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Human Immunodeficiency Virus ◽  
T Cells ◽  
Immunodeficiency Virus ◽  
Human Immunodeficiency Virus 1

In vitro effect of oral antiseptics on human immunodeficiency virus-1 and herpes simplex virus type 1

2001 ◽  
Vol 28 (7) ◽  
pp. 610-616 ◽  
Author(s):  
A. A. M. A. Baqui ◽  
Jacqueline I. Kelley ◽  
Mary Ann Jabra-Rizk ◽  
Louis G. DePaola ◽  
William A. Falkler ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Herpes Simplex Virus Type ◽  
Immunodeficiency Virus ◽  
Simplex Virus ◽  
Vitro Effect ◽  
Human Immunodeficiency Virus 1
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