scholarly journals Synergistic neurotoxicity of opioids and human immunodeficiency virus-1 Tat protein in striatal neurons in vitro

Neuroscience ◽  
2001 ◽  
Vol 102 (3) ◽  
pp. 555-563 ◽  
Author(s):  
J.A. Gurwell ◽  
A. Nath ◽  
Q. Sun ◽  
J. Zhang ◽  
K.M. Martin ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Tat Protein ◽  
Striatal Neurons ◽  
Immunodeficiency Virus ◽  
Human Immunodeficiency Virus 1

scholarly journals Human immunodeficiency virus 1 tat protein binds trans-activation-responsive region (TAR) RNA in vitro.

1989 ◽  
Vol 86 (18) ◽  
pp. 6925-6929 ◽  
Author(s):  
C. Dingwall ◽  
I. Ernberg ◽  
M. J. Gait ◽  
S. M. Green ◽  
S. Heaphy ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Tat Protein ◽  
Immunodeficiency Virus ◽  
Tar Rna ◽  
Human Immunodeficiency Virus 1

scholarly journals HIV-1LAI Nef blocks the development of hematopoietic stem/progenitor cells into myeloid-erythroid lineage cells

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Wei Zou ◽  
Juanjuan Xing ◽  
Shijie Zou ◽  
Mei Jiang ◽  
Xinping Chen ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Progenitor Cells ◽  
Cell Loss ◽  
Underlying Mechanism ◽  
Humanized Mice ◽  
Hematopoietic Stem ◽  
Immunodeficiency Virus ◽  
Hiv 1 ◽  
Human Immunodeficiency Virus 1

Abstract Background A variety of hematopoietic abnormalities are commonly seen in human immunodeficiency virus-1 (HIV-1) infected individuals despite antiviral therapy, but the underlying mechanism remains elusive. Nef plays an important role in HIV-1 induced T cell loss and disease progression, but it is not known whether Nef participates in other hematopoietic abnormalities associated with infection. Results In the current study we investigated the influence of HIV-1LAI Nef (LAI Nef) on the development of hematopoietic stem/progenitor cells (HSPCs) into myeloid-erythroid lineage cells, and found that nef expression in HSPCs blocked their differentiation both in vitro and in humanized mice reconstituted with nef-expressing HSPCs. Conclusions Our novel findings demonstrate LAI Nef compromised the development of myeloid-erythroid lineage cells, and therapeutics targeting Nef would be promising in correcting HIV-1 associated hematopoietic abnormalities.

scholarly journals Replication of the human immunodeficiency virus 1 and impaired differentiation of T cells after in vitro infection of bone marrow immature T cells.

1989 ◽  
Vol 83 (2) ◽  
pp. 610-615 ◽  
Author(s):  
Y Lunardi-Iskandar ◽  
M T Nugeyre ◽  
V Georgoulias ◽  
F Barré-Sinoussi ◽  
C Jasmin ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Human Immunodeficiency Virus ◽  
T Cells ◽  
Immunodeficiency Virus ◽  
Human Immunodeficiency Virus 1
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