Calbindin-D28Kand ischemic damage of pyramidal cells in rat hippocampus

1992 ◽  
Vol 31 (1) ◽  
pp. 89-95 ◽  
Author(s):  
A. Rami ◽  
A. Rabié ◽  
M. Thomasset ◽  
J. Krieglstein
Keyword(s):  
Pyramidal Cells ◽  
Rat Hippocampus ◽  
Ischemic Damage

scholarly journals Location of Sialoglycoconjugates Containing the Siaα2–3Gal and Siaα2–6Gal Groups in the Rat Hippocampus and the Effect of Aging on Their Expression

2001 ◽  
Vol 49 (10) ◽  
pp. 1311-1319 ◽  
Author(s):  
Yuji Sato ◽  
Yoshihiro Akimoto ◽  
Hayato Kawakami ◽  
Hiroshi Hirano ◽  
Tamao Endo
Keyword(s):  
Electron Microscopy ◽  
Plasma Membranes ◽  
Pyramidal Cells ◽  
Staining Intensity ◽  
Rat Hippocampus ◽  
Maackia Amurensis ◽  
Ca1 Region ◽  
Old Rats ◽  
Maackia Amurensis Lectin ◽  
Stratum Lacunosum Moleculare

The histochemical distribution of sialoglycoconjugates in the CA1 region in the hippocampus formation of 9-week-old rats and 30-month-old rats was examined using electron microscopy in combination with two lectins, Maackia amurensis lectin, specific for Siaα2–3Gal, and Sambucus sieboldiana agglutinin, specific for Siaα2–6Gal. Each lectin stained the plasma membranes of pyramidal cells, indicating that the Siaα2–3Gal and Siaα2–6Gal groups were expressed on their plasma membranes. These lectins also bound to synapses in the stratum lacunosum moleculare. The staining intensity of the lectins in the synapses in these layers was downregulated in the 30-month-old rats. These results indicated that both the Siaα2–3Gal and Siaα2–6Gal groups are expressed on these synapses and that the expression of these sialyl linkages decreases in the aged brain.

Autoradiographic Localization of Opioid and Spirodecanone Receptors in the Gerbil Hippocampus as Compared with the Rat Hippocampus

1988 ◽  
Vol 8 (4) ◽  
pp. 568-574 ◽  
Author(s):  
Hiroshi Onodera ◽  
Kyuya Kogure
Keyword(s):  
Opioid Receptor ◽  
Binding Sites ◽  
Cellular Localization ◽  
Neuronal Damage ◽  
Pyramidal Cells ◽  
Rat Hippocampus ◽  
High Concentration ◽  
Receptor Sites ◽  
Ca3 Neurons

Opioid ([3H]naloxone) and spirodecanone ([3H]spiperone) binding sites in the hippocampus were visualized in the Mongolian gerbil and in the rat using in vitro autoradiography. In the hippocampus, marked differences were noted in the stratum (sr.) pyramidale of the CA1 subfield where opioid and spirodecanone (assayed in the presence of mianserin and sulpiride) binding activities were very low in gerbils, but high in rats. Gerbils exhibited a high concentration of [3H]naloxone binding sites in the sr. pyramidale of the CA3 subfield, as observed in the rat. In addition, the gerbil has a very high opioid receptor density in the hilar region and in the sr. moleculare of the dentate gyrus. The cellular localization of opioid and spirodecanone receptor sites was studied in the rat hippocampus using selective neuronal damage to CA1 and CA3 neurons by means of ischemia and kainic acid treatment, respectively. The results suggest that the gerbil differs from the rat with respect to the characteristic pyramidal cells (spirodecanone binding site) and interneurons (opioid receptor) in the CA1 subfield of the hippocampus. Distinct localization of opioid and spirodecanone receptors in the gerbil provides a good model with which to investigate the electrophysiological and biochemical roles of opioid peptides and butyrophenone spirodecanone drugs.

Post-ischemic treatment with a lazaroid (U74389G) prevents transient global ischemic damage in rat hippocampus

1997 ◽  
Vol 19 (4) ◽  
pp. 431-434 ◽  
Author(s):  
Michael Tseng ◽  
Shyue-An Chan ◽  
Kenneth Reid ◽  
Vasudeva Iyer
Keyword(s):  
Rat Hippocampus ◽  
Ischemic Damage

Serotonin blocks the facilitatory action of muscarinic and nicotinic agents in the hippocampus in vivo

1989 ◽  
Vol 67 (1) ◽  
pp. 47-53 ◽  
Author(s):  
Y. Hong ◽  
K. Krnjević
Keyword(s):  
Inhibitory Action ◽  
Pyramidal Cells ◽  
Inhibitory Effect ◽  
Population Spike ◽  
Rat Hippocampus ◽  
Population Spikes ◽  
Ca1 Region ◽  
Facilitatory Action ◽  
Hippocampal Pyramidal Cells

The inhibitory effect of serotonin, released iontophoretically, on acetylcholine-induced facilitation of population spikes evoked by fimbria–commissural stimulation was studied in the CA1 region of rat hippocampus in vivo. After serotonin was applied for 2.6 ± 0.8 min, acetylcholine's action was inhibited in 39 cases out of 57 (68.4%), by 68.9 ± 23.1%, irrespective of whether serotonin alone increased or reduced the population spike. Spiperone, used as a 5-hydroxytryptamine1A (5-HT1A) antagonist, suppressed the inhibitory action of serotonin in 14 of 21 tests. Serotonin had similar effects on population spike facilitations induced by acetyl-β-methylcholine and dimethylphenylpiperazinium. Thus serotonin, probably acting on 5-HT1A receptors, blocks effectively but indiscriminately all cholinergic facilitations, whether mediated by nicotinic or muscarinic receptors.Key words: serotonin, cholinergic facilitation, hippocampal pyramidal cells, spiperone, muscarinic and nicotinic actions.

Cannabinoid receptor activation in CA1 pyramidal cells in adult rat hippocampus

2000 ◽  
Vol 863 (1-2) ◽  
pp. 120-131 ◽  
Author(s):  
M.Todd Kirby ◽  
Robert E Hampson ◽  
Sam A Deadwyler
Keyword(s):  
Cannabinoid Receptor ◽  
Pyramidal Cells ◽  
Receptor Activation ◽  
Rat Hippocampus ◽  
Adult Rat ◽  
Ca1 Pyramidal Cells

Serotonin-mediated neurotransmission in the pyramidal cells of the rat hippocampus

2002 ◽  
Vol 17 (4) ◽  
pp. 231-250
Author(s):  
Machko Matsumoto ◽  
Taku Kojima ◽  
Mitsuhiro Yoshioka ◽  
Kaori Tachibana ◽  
Satoshi Ohashi ◽  
...  
Keyword(s):  
Pyramidal Cells ◽  
Rat Hippocampus
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