Tensile properties of human knee joint cartilage: I. Influence of ionic conditions, weight bearing, and fibrillation on the tensile modulus

Knee joint is the hub of human lower limb movement and it is also an important weight-bearing joint, which has the characteristics of load-bearing and heavy physical activities. So the knee joint becomes the predilection site of clinical disease. Once people have the cartilage lesions, their daily life will be affected seriously. The simulation of the knee joint lesions could provide help for clinical knee-joint treatment. Based on the complete model of knee joint, this paper use the finite element method to analyze the biomechanical characteristics of the defective knee joint. The results of simulation show that the stress of cartilages when standing on single leg is approximately doubled than that of standing on two legs. When standing on single leg, the 8-mm diameter osteochondral defect in femur cartilage can generate maximal changes in von-mises stress (by 36.74%), while the von-mises stress on tibia cartilage with 8-mm defect increase by 87%. The stress distribution of cartilages is almost the same, there is no obvious stress concentration when in defect. Increasing the defective diameter, femoral cartilage, meniscus and tibial all present an increasing trend towards stress. When increasing the applied load, the stress of the femoral cartilage, the meniscus and the tibial cartilage all increased.

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Expression profiles of two types of human knee-joint cartilage

Journal of Human Genetics ◽

10.1007/s10038-003-0004-8 ◽

2003 ◽

Vol 48 (4) ◽

pp. 177-182 ◽

Cited By ~ 26

Author(s):

Kensuke Ochi ◽

Yataro Daigo ◽

Toyomasa Katagiri ◽

Akihiko Saito-Hisaminato ◽

Tatsuhiko Tsunoda ◽

...

Keyword(s):

Knee Joint ◽

Expression Profiles ◽

Joint Cartilage ◽

Human Knee ◽

Human Knee Joint

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Content and Composition of Glycosaminoglycans in Human Knee Joint Cartilage: Variation with Site and Age in Adults

Connective Tissue Research ◽

10.3109/03008207509152172 ◽

1975 ◽

Vol 3 (2-3) ◽

pp. 141-147 ◽

Cited By ~ 48

Author(s):

Anders Bjelle

Keyword(s):

Knee Joint ◽

Joint Cartilage ◽

Human Knee ◽

Human Knee Joint

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Direct Validation of Human Knee-Joint Contact Mechanics Derived From Subject-Specific Finite-Element Models of the Tibiofemoral and Patellofemoral Joints

Journal of Biomechanical Engineering ◽

10.1115/1.4045594 ◽

2020 ◽

Vol 142 (7) ◽

Cited By ~ 2

Author(s):

Wei Gu ◽

Marcus G. Pandy

Keyword(s):

Finite Element ◽

Knee Joint ◽

Contact Mechanics ◽

Contact Pressure ◽

Weight Bearing ◽

Human Knee ◽

Human Knee Joint ◽

Joint Contact ◽

Joint Contact Pressure

Abstract The primary aim of this study was to validate predictions of human knee-joint contact mechanics (specifically, contact pressure, contact area, and contact force) derived from finite-element models of the tibiofemoral and patellofemoral joints against corresponding measurements obtained in vitro during simulated weight-bearing activity. A secondary aim was to perform sensitivity analyses of the model calculations to identify those parameters that most significantly affect model predictions of joint contact pressure, area, and force. Joint pressures in the medial and lateral compartments of the tibiofemoral and patellofemoral joints were measured in vitro during two simulated weight-bearing activities: stair descent and squatting. Model-predicted joint contact pressure distribution maps were consistent with those obtained from experiment. Normalized root-mean-square errors between the measured and calculated contact variables were on the order of 15%. Pearson correlations between the time histories of model-predicted and measured contact variables were generally above 0.8. Mean errors in the calculated center-of-pressure locations were 3.1 mm for the tibiofemoral joint and 2.1 mm for the patellofemoral joint. Model predictions of joint contact mechanics were most sensitive to changes in the material properties and geometry of the meniscus and cartilage, particularly estimates of peak contact pressure. The validated finite element modeling framework offers a useful tool for noninvasive determination of knee-joint contact mechanics during dynamic activity under physiological loading conditions.

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