Mesenchymal stem cells derived from synovium, meniscus, anterior cruciate ligament, and articular chondrocytes share similar gene expression profiles

Human mesenchymal stem cells have a high potential in regenerative medicine. They can be isolated from a variety of adult tissues, including bone marrow, and can be differentiated into multiple cell types of the mesodermal lineage, including adipocytes, osteocytes, and chondrocytes. Stem cell differentiation is controlled by a process of interacting lineage-specific and multipotent genes. In this chapter, the authors use full genome microarrays to explore gene expression profiles in the process of Osteo-, Adipo-, and Chondro-Genic lineage commitment of human mesenchymal stem cells.

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Gene expression profiles of early adipogenesis in human mesenchymal stem cells

Gene ◽

10.1016/j.gene.2004.06.028 ◽

2004 ◽

Vol 340 (1) ◽

pp. 141-150 ◽

Cited By ~ 52

Author(s):

Shih-Chieh Hung ◽

Ching-Fang Chang ◽

Hsiao-Li Ma ◽

Tain-Hsiung Chen ◽

Larry Low-Tone Ho

Keyword(s):

Gene Expression ◽

Stem Cells ◽

Mesenchymal Stem Cells ◽

Expression Profiles ◽

Human Mesenchymal Stem Cells ◽

Gene Expression Profiles

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Effect of cell source and osteoblast differentiation on gene expression profiles of mesenchymal stem cells derived from bone marrow or adipose tissue

Journal of Cellular Biochemistry ◽

10.1002/jcb.28463 ◽

2019 ◽

Vol 120 (7) ◽

pp. 11842-11852 ◽

Cited By ~ 5

Author(s):

Simone Ortiz Moura Fideles ◽

Adriana Cassia Ortiz ◽

Amanda Freire Assis ◽

Max Jordan Duarte ◽

Fabiola Singaretti Oliveira ◽

...

Keyword(s):

Gene Expression ◽

Stem Cells ◽

Bone Marrow ◽

Mesenchymal Stem Cells ◽

Adipose Tissue ◽

Osteoblast Differentiation ◽

Expression Profiles ◽

Gene Expression Profiles ◽

Cell Source

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Genetic basis of ruminant headgear and rapid antler regeneration

Science ◽

10.1126/science.aav6335 ◽

2019 ◽

Vol 364 (6446) ◽

pp. eaav6335 ◽

Cited By ~ 29

Author(s):

Yu Wang ◽

Chenzhou Zhang ◽

Nini Wang ◽

Zhipeng Li ◽

Rasmus Heller ◽

...

Keyword(s):

Gene Expression ◽

Stem Cells ◽

Tumor Suppressor ◽

Tumor Suppressor Genes ◽

Genetic Basis ◽

Expression Profiles ◽

Gene Expression Profiles ◽

Neural Crest Stem Cells ◽

Organ Regeneration ◽

Similar Gene

Ruminants are the only extant mammalian group possessing bony (osseous) headgear. We obtained 221 transcriptomes from bovids and cervids and sequenced three genomes representing the only two pecoran lineages that convergently lack headgear. Comparative analyses reveal that bovid horns and cervid antlers share similar gene expression profiles and a common cellular basis developed from neural crest stem cells. The rapid regenerative properties of antler tissue involve exploitation of oncogenetic pathways, and at the same time some tumor suppressor genes are under strong selection in deer. These results provide insights into the evolutionary origin of ruminant headgear as well as mammalian organ regeneration and oncogenesis.

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