Subject-specific modeling of muscle force and knee contact in total knee arthroplasty

"The goal of this dissertation is to develop a musculoskeletal model and corroborate model predictions to experimentally measured in vivo knee contact forces, in order to study the biomechanical consequences of two different total knee arthroplasty designs. The two main contributions of this dissertation are: (1) Corroboration to experimental data: The development of an EMG-driven, full-body, musculoskeletal model with subject-specific leg geometries including deformable contacts, ligaments, 6DOF knee joint, and a shoe-floor model that can concurrently predict muscle forces, ligament forces, and joint contact forces. Model predictions of tibiofemoral joint contact forces were evaluated against the subject-specific in vivo measurements from the instrumented TKR for three distinctly different styles of over ground gait. (2) Virtual surgery in TKA: The musculoskeletal modeling methodology was then used to develop a model for one healthy participant with a native knee and then virtually replacing the native knee with fixed-bearing and mobile-bearing total knee arthroplasty designs performing gait and step-up tasks. This approach minimized the biomechanical impact of variations in sex, geometry, implant size, design and positioning, ligament location and tension, and muscle forces found across patients. The differences in biomechanics were compared for the two designs. 1.2 Significance of this Research The world health organization ranks musculoskeletal disorders as the second largest contributor to disability worldwide. Conservative estimates put the national cost of direct care for musculoskeletal disease at $212.7 billion a year [1]. Many people who suffer from neuromuscular or musculoskeletal diseases may benefit from the insights gained from surgery simulations, since musculoskeletal reconstructions are commonly performed on these individuals. Improved surgical outcomes will benefit these individuals not only in the short-term, but also in the long-term, since their future rehabilitation needs may be reduced. For example, although total knee arthroplasty is a common surgical procedure for the treatment of osteoarthritis with over 700,000 procedures performed each year [2], many patients are unhappy with the ultimate results [3]. Ten to 30% of patients report [4] pain, dissatisfaction with function, and the need for further surgery such as revision after the initial surgery resulting in costs exceeding $11 billion [5]. Potentially, simulation studies that quantify the important biomechanical variables will reduce the need for revision surgeries in patients."--Introduction.

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Evaluation of a subject-specific musculoskeletal modelling framework for load prediction in total knee arthroplasty

Medical Engineering & Physics ◽

10.1016/j.medengphy.2016.04.010 ◽

2016 ◽

Vol 38 (8) ◽

pp. 708-716 ◽

Cited By ~ 28

Author(s):

Zhenxian Chen ◽

Zhifeng Zhang ◽

Ling Wang ◽

Dichen Li ◽

Yuanzhi Zhang ◽

...

Keyword(s):

Total Knee Arthroplasty ◽

Knee Arthroplasty ◽

Load Prediction ◽

Musculoskeletal Modelling ◽

Modelling Framework ◽

Subject Specific ◽

Total Knee

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Potential Instability and Malfunction of Knee Joints with Vastus Medialis Impairment after Total Knee Arthroplasty

Applied Sciences ◽

10.3390/app11062764 ◽

2021 ◽

Vol 11 (6) ◽

pp. 2764

Author(s):

Yongkyung Lee ◽

Hai-Mi Yang ◽

Jinju Jang ◽

Dai-Soon Kwak ◽

Jungsung Kim ◽

...

Keyword(s):

Total Knee Arthroplasty ◽

Knee Arthroplasty ◽

Muscle Force ◽

Knee Joints ◽

Force Distribution ◽

Vastus Medialis ◽

Reaction Forces ◽

Total Knee ◽

Joint Reaction ◽

Total Test

Four pairs of fresh-frozen cadaver knees (eight knees, four male knees) with a mean age of 72 ± 7 years were used for tests involving a customized simulator capable of controlling quadriceps loading conditions. The muscle force distribution of the quadriceps for the normal loading condition was applied on the basis of muscle cross-sectional area data, as previously reported (VM: 31 N; RF/VI: 49 N; VL: 45 N). To simulate vastus medialis (VM) impairment, we set the muscle force for VM in the muscle force distribution of the quadriceps at zero (VM: 0 N; RF/VI: 49 N; VL: 45 N). The joint reaction forces and moments on knee joints that underwent total knee arthroplasty (TKA) did not differ significantly according to VM impairment status for all flexion angles (p > 0.05). Nevertheless, the vectors of internal–external moments mostly showed a tendency for alteration from external to internal due to VM impairment. This tendency was evident in 9 cases in 12 total test pairs (with and without VM impairment). Furthermore, the vectors of the anterior–posterior reaction forces mostly showed a tendency to increase anteriorly due to VM impairment. This tendency was also evident in 9 cases in 12 total test pairs (with and without VM impairment). These results indicate that posterior dislocation of the tibia may be induced if VM impairment occurs after TKA. In conclusion, VM impairment in knee joints undergoing TKA may contribute to posterior dislocation of the tibia by a paradoxical roll-back with enhancements of the anterior joint reaction force and external moment during knee-joint flexion. Our findings may be valuable for understanding the mechanism of potential instability and malfunction due to VM impairment in knee joints after TKA, and may help to optimize clinical/rehabilitation training plans to improve the prognosis (stability and function) of knee joints undergoing TKA.

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The Use of Electrical Stimulation to Increase Quadriceps Femoris Muscle Force in an Elderly Patient Following a Total Knee Arthroplasty

Physical Therapy ◽

10.1093/ptj/81.9.1565 ◽

2001 ◽

Vol 81 (9) ◽

pp. 1565-1571 ◽

Cited By ~ 48

Author(s):

Michael Lewek ◽

Jennifer Stevens ◽

Lynn Snyder-Mackler

Keyword(s):

Total Knee Arthroplasty ◽

Electrical Stimulation ◽

Knee Arthroplasty ◽

Muscle Force ◽

Effective Means ◽

Neuromuscular Electrical Stimulation ◽

Quadriceps Femoris ◽

Quadriceps Femoris Muscle ◽

Total Knee ◽

Femoris Muscle

Abstract Background and Purpose. Persistent residual quadriceps femoris muscle force deficits after total knee arthroplasty (TKA) are commonly reported and can prevent patients from returning quickly and fully to functional activities. Neuromuscular electrical stimulation offers a potentially more effective means of increasing muscle force than current rehabilitation protocols. Case Description. The patient was a 66-year-old man. Neuromuscular electrical stimulation for increasing quadriceps femoris muscle force was initiated 3 weeks after TKA for 11 sessions to supplement stretching exercises and a high-intensity volitional strengthening program. Outcome. The patient's isometric quadriceps femoris muscle force increased from 50% (involved/uninvolved) at 3 weeks after surgery to 86% at 8 weeks after surgery. A concurrent increase in his uninvolved quadriceps femoris muscle force concealed the patient's true increase in his involved quadriceps femoris muscle force in a side-to-side comparison. The patient's final involved quadriceps femoris muscle force (10 weeks after surgery) was 93% of the initial uninvolved quadriceps femoris muscle force. Discussion. Our patient was able to return to independent activities of daily living and recreational activities, with force gains that surpassed those reported in the literature.

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Primary Total Knee Arthroplasty in Patients Receiving Workers' Compensation Benefits

Yearbook of Orthopedics ◽

10.1016/s0276-1092(08)70442-5 ◽

2006 ◽

Vol 2006 ◽

pp. 144-145

Author(s):

B.F. Morrey

Keyword(s):

Total Knee Arthroplasty ◽

Knee Arthroplasty ◽

Primary Total Knee Arthroplasty ◽

Workers Compensation ◽

Total Knee ◽

Primary Total Knee

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Trends in Periprosthetic Knee Infection and Associated Costs: A Population-Based Study Using National Data

The Journal of Knee Surgery ◽

10.1055/s-0040-1701516 ◽

2020 ◽

Author(s):

Robert Brochin ◽

Jashvant Poeran ◽

Khushdeep S. Vig ◽

Aakash Keswani ◽

Nicole Zubizarreta ◽

...

Keyword(s):

Total Knee Arthroplasty ◽

Length Of Stay ◽

Knee Arthroplasty ◽

Trend Test ◽

Strong Impact ◽

Hospitalization Costs ◽

Teaching Status ◽

Increasing Trend ◽

Total Knee ◽

Increasing Trends

AbstractGiven increasing demand for primary knee arthroplasties, revision surgery is also expected to increase, with periprosthetic joint infection (PJI) a main driver of costs. Recent data on national trends is lacking. We aimed to assess trends in PJI in total knee arthroplasty revisions and hospitalization costs. From the National Inpatient Sample (2003–2016), we extracted data on total knee arthroplasty revisions (n = 782,449). We assessed trends in PJI prevalence and (inflation-adjusted) hospitalization costs (total as well as per-day costs) for all revisions and stratified by hospital teaching status (rural/urban by teaching status), hospital bed size (≤299, 300–499, and ≥500 beds), and hospital region (Northeast, Midwest, South, and West). The Cochran–Armitage trend test (PJI prevalence) and linear regression determined significance of trends. PJI prevalence overall was 25.5% (n = 199,818) with a minor increasing trend: 25.3% (n = 7,828) in 2003 to 28.9% (n = 19,275) in 2016; p < 0.0001. Median total hospitalization costs for PJI decreased slightly ($23,247 in 2003–$20,273 in 2016; p < 0.0001) while median per-day costs slightly increased ($3,452 in 2003–$3,727 in 2016; p < 0.0001), likely as a function of decreasing length of stay. With small differences between hospitals, the lowest and highest PJI prevalences were seen in small (≤299 beds; 22.9%) and urban teaching hospitals (27.3%), respectively. In stratification analyses, an increasing trend in PJI prevalence was particularly seen in larger (≥500 beds) hospitals (24.4% in 2003–30.7% in 2016; p < 0.0001), while a decreasing trend was seen in small-sized hospitals. Overall, PJI in knee arthroplasty revisions appears to be slightly increasing. Moreover, increasing trends in large hospitals and decreasing trends in small-sized hospitals suggest a shift in patients from small to large volume hospitals. Decreasing trends in total costs, alongside increasing trends in per-day costs, suggest a strong impact of length of stay trends and a more efficient approach to PJI over the years (in terms of shorter length of stay).

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Effect of Manipulation under Anesthesia of the First Knee in Staged Bilateral Total Knee Arthroplasty on Clinical Outcome and Satisfaction

The Journal of Knee Surgery ◽

10.1055/s-0040-1709675 ◽

2020 ◽

Author(s):

Jung-Won Lim ◽

Yong-Beom Park ◽

Dong-Hoon Lee ◽

Han-Jun Lee

Keyword(s):

Total Knee Arthroplasty ◽

Patient Satisfaction ◽

Clinical Outcome ◽

Clinical Outcomes ◽

Knee Arthroplasty ◽

Knee Flexion ◽

Functional Score ◽

Manipulation Under Anesthesia ◽

Total Knee

AbstractThis study aimed to evaluate whether manipulation under anesthesia (MUA) affect clinical outcome including range of motion (ROM) and patient satisfaction after total knee arthroplasty (TKA). It is hypothesized that MUA improves clinical outcomes and patient satisfaction after primary TKA. This retrospective study analyzed 97 patients who underwent staged bilateral primary TKA. MUA of knee flexion more than 120 degrees was performed a week after index surgery just before operation of the opposite site. The first knees with MUA were classified as the MUA group and the second knees without MUA as the control group. ROM, Knee Society Knee Score, Knee Society Functional Score, Western Ontario and McMaster Universities (WOMAC) score, and patient satisfaction were assessed. Postoperative flexion was significantly greater in the MUA group during 6 months follow-up (6 weeks: 111.6 vs. 99.8 degrees, p < 0.001; 3 months: 115.9 vs. 110.2 degrees, p = 0.001; 6 months: 120.2 vs. 117.0 degrees, p = 0.019). Clinical outcomes also showed similar results with knee flexion during 2 years follow-up. Patient satisfaction was significantly high in the MUA group during 12 months (3 months: 80.2 vs. 71.5, p < 0.001; 6 months: 85.8 vs. 79.8, p < 0.001; 12 months: 86.1 vs. 83.9, p < 0.001; 24 months: 86.6 vs. 85.5, p = 0.013). MUA yielded improvement of clinical outcomes including ROM, and patient satisfaction, especially in the early period after TKA. MUA in the first knee could be taken into account to obtain early recovery and to improve patient satisfaction in staged bilateral TKA.

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A Comparative Analysis of Patient Satisfaction following Total Knee Arthroplasty and Total Hip Arthroplasty Using the Forgotten Joint Score

The Journal of Hip Surgery ◽

10.1055/s-0040-1712523 ◽

2020 ◽

Vol 04 (02) ◽

pp. 084-089

Author(s):

Vivek Singh ◽

Stephen Zak ◽

Ran Schwarzkopf ◽

Roy Davidovitch

Keyword(s):

Total Knee Arthroplasty ◽

Patient Satisfaction ◽

Total Hip Arthroplasty ◽

Knee Arthroplasty ◽

Hip Arthroplasty ◽

Demographic Data ◽

Demographic Differences ◽

Total Hip ◽

Forgotten Joint Score ◽

Total Knee

AbstractMeasuring patient satisfaction and surgical outcomes following total joint arthroplasty remains controversial with most tools failing to account for both surgeon and patient satisfaction in regard to outcomes. The purpose of this study was to use “The Forgotten Joint Score” questionnaire to assess clinical outcomes comparing patients who underwent a total hip arthroplasty (THA) with those who underwent a total knee arthroplasty (TKA). We conducted a retrospective review of patients who underwent primary THA or TKA between September 2016 and September 2019 and responded to the Forgotten Joint Score-12 (FJS-12) questionnaire at least at one of three time periods (3, 12, and 21 months), postoperatively. An electronic patient rehabilitation application was used to administer the questionnaire. Collected variables included demographic data (age, gender, race, body mass index [BMI], and smoking status), length of stay (LOS), and FJS-12 scores. t-test and chi-square were used to determine significance. Linear regression was used to account for demographic differences. A p-value of less than 0.05 was considered statistically significant. Of the 2,359 patients included in this study, 1,469 underwent a THA and 890 underwent a TKA. Demographic differences were observed between the two groups with the TKA group being older, with higher BMI, higher American Society of Anesthesiologists scores, and longer LOS. Accounting for the differences in demographic data, THA patients consistently had higher scores at 3 months (53.72 vs. 24.96; p < 0.001), 12 months (66.00 vs. 43.57; p < 0.001), and 21 months (73.45 vs. 47.22; p < 0.001). FJS-12 scores for patients that underwent THA were significantly higher in comparison to TKA patients at 3, 12, and 21 months postoperatively. Increasing patient age led to a marginal increase in FJS-12 score in both cohorts. With higher FJS-12 scores, patients who underwent THA may experience a more positive evolution with their surgery postoperatively than those who had TKA.

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