Comparison of the Effects of Chemical Permeation Enhancers on the Lipoidal Pathways of Human Epidermal Membrane and Hairless Mouse Skin and The Mechanism of Enhancer Action

2007 ◽  
Vol 96 (9) ◽  
pp. 2310-2326 ◽  
Author(s):  
Doungdaw Chantasart ◽  
Piyanuch Sa‐Nguandeekul ◽  
Sompol Prakongpan ◽  
S.Kevin Li ◽  
William I. Higuchi
Keyword(s):  
Mouse Skin ◽  
Hairless Mouse ◽  
Permeation Enhancers ◽  
Hairless Mouse Skin ◽  
Chemical Permeation Enhancers ◽  
Human Epidermal Membrane ◽  
Epidermal Membrane ◽  
Chemical Permeation

Model analysis of flux enhancement across hairless mouse skin induced by chemical permeation enhancers

2005 ◽  
Vol 297 (1-2) ◽  
pp. 9-21 ◽  
Author(s):  
Ning He ◽  
Kevin S. Warner ◽  
William I. Higuchi ◽  
S. Kevin Li
Keyword(s):  
Mouse Skin ◽  
Model Analysis ◽  
Hairless Mouse ◽  
Permeation Enhancers ◽  
Flux Enhancement ◽  
Hairless Mouse Skin ◽  
Chemical Permeation Enhancers ◽  
Chemical Permeation

Mechanistic Study of Alkyl Azacycloheptanones as Skin Permeation Enhancers by Permeation and Partition Experiments with Hairless Mouse Skin

2003 ◽  
Vol 92 (2) ◽  
pp. 297-310 ◽  
Author(s):  
Ning He ◽  
S.Kevin Li ◽  
T.Marjukka Suhonen ◽  
Kevin S. Warner ◽  
William I. Higuchi
Keyword(s):  
Skin Permeation ◽  
Mouse Skin ◽  
Hairless Mouse ◽  
Mechanistic Study ◽  
Permeation Enhancers ◽  
Hairless Mouse Skin

Dose and Timing of the First Light Fraction in Two-fold Illumination Schemes for Topical ALA-mediated Photodynamic Therapy of Hairless Mouse Skin¶

2003 ◽  
Vol 77 (3) ◽  
pp. 319 ◽  
Author(s):  
Dominic J. Robinson ◽  
Henriëtte S. de Bruijn ◽  
Willem M. Star ◽  
Henricus J. C. M. Sterenborg
Keyword(s):  
Photodynamic Therapy ◽  
Mouse Skin ◽  
Hairless Mouse ◽  
Light Fraction ◽  
Hairless Mouse Skin

Chemical Permeation Enhancers for Transdermal Delivery of Thiocolchicoside: Assessment of Ex-vivo Skin Flux and In-vivo Pharmacokinetics

2017 ◽  
Vol 10 (5) ◽  
pp. 3827-3835
Author(s):  
Y Madhusudan Rao ◽  
Gayatri P ◽  
Ajitha M ◽  
P. Pavan Kumar ◽  
Kiran kumar
Keyword(s):  
Passive Control ◽  
Ex Vivo ◽  
Skin Permeation ◽  
In Vivo Studies ◽  
Permeation Enhancers ◽  
Casting Technique ◽  
Chemical Permeation Enhancers ◽  
Chemical Permeation ◽  
In Vivo Pharmacokinetics

Present investigation comprises the study of ex-vivo skin flux and in-vivo pharmacokinetics of Thiocolchicoside (THC) from transdermal films. The films were fabricated by solvent casting technique employing combination of hydrophilic and hydrophobic polymers. A flux of 18.08 µg/cm2h and 13.37µg/cm2h was achieved for optimized formulations containing 1, 8-cineole and oleic acid respectively as permeation enhancers. The observed flux values were higher when compared to passive control (8.66 µg/cm2h). Highest skin permeation was observed when 1,8-cineole was used as chemical permeation enhancer and it considerably (2-2.5 fold) improved the THC transport across the rat skin. In vivo studies were performed in rabbits and samples were analysed by LC-MS-MS. The mean area under the curve (AUC) values of transdermal film showed about 2.35 times statistically significant (p<0.05) improvement in bioavailability when compared with the oral administration of THC solution. The developed transdermal therapeutic systems using chemical permeation enhancers were suitable for drugs like THC in effective management of muscular pain.    

Antioxidative Effects of Skinned Mugwort (Artemisia vulgaris L.) Extracts on UV-Irradiated Hairless Mouse Skin

2008 ◽  
Vol 37 (1) ◽  
pp. 20-26 ◽  
Author(s):  
Si-Hyang Park ◽  
Duck-Moon Cho ◽  
Byeong-Dae Choi ◽  
Yeung-Joon Choi ◽  
Jin-Ho Choi
Keyword(s):  
Mouse Skin ◽  
Hairless Mouse ◽  
Artemisia Vulgaris ◽  
Hairless Mouse Skin ◽  
Antioxidative Effects

Transdermal Delivery of Acyclovir Sodium Via Carbopol Gels: Role of Chemical Permeation Enhancers

2011 ◽  
Vol 8 (4) ◽  
pp. 381-389 ◽  
Author(s):  
Raju Jukanti ◽  
Ashok Mateti ◽  
Suresh Bandari ◽  
Prabhakar R Veerareddy
Keyword(s):  
Transdermal Delivery ◽  
Permeation Enhancers ◽  
Chemical Permeation Enhancers ◽  
Chemical Permeation

Permeation of hairless mouse skin I: Experimental methods and comparison with human epidermal permeation by alkanols

1980 ◽  
Vol 69 (7) ◽  
pp. 781-786 ◽  
Author(s):  
Hugo Durrheim ◽  
Gordon L. Flynn ◽  
William I. Higuchi ◽  
Charan R. Behl
Keyword(s):  
Mouse Skin ◽  
Experimental Methods ◽  
Hairless Mouse ◽  
Hairless Mouse Skin

UVA- and UVB-induced changes in hairless mouse skin collagen

1994 ◽  
Vol 286 (8) ◽  
pp. 490-494 ◽  
Author(s):  
F. Trautinger ◽  
K. Mazzucco ◽  
R. M. Knobler ◽  
A. Trenz ◽  
E. -M. Kokoschka
Keyword(s):  
Mouse Skin ◽  
Hairless Mouse ◽  
Hairless Mouse Skin ◽  
Skin Collagen ◽  
Induced Changes
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