Application of Membrane Filtration to Antibiotic Quality Control Sterility Testing

1966 ◽  
Vol 55 (8) ◽  
pp. 818-821 ◽  
Author(s):  
Frances W. Bowman
Keyword(s):  
Quality Control ◽  
Membrane Filtration ◽  
Sterility Testing

Sterility Testing of Insulin by Membrane Filtration: A Collaborative Study

1970 ◽  
Vol 59 (7) ◽  
pp. 1022-1024 ◽  
Author(s):  
Miriam P. Calhoun ◽  
Mack White ◽  
Frances W. Bowman
Keyword(s):  
Membrane Filtration ◽  
Collaborative Study ◽  
Sterility Testing

A Practical Method of Sterility Monitoring of IV Admixtures and a Method of Implementing a Routine Sterility Monitoring Program

1973 ◽  
Vol 7 (6) ◽  
pp. 276-279 ◽  
Author(s):  
J.A. Buth ◽  
R.W. Coberly ◽  
F.M. Eckel
Keyword(s):  
Pilot Study ◽  
Membrane Filtration ◽  
Monitoring Program ◽  
Practical Method ◽  
Sterility Testing ◽  
Practical Procedure ◽  
Plastic Bags ◽  
Pharmaceutical Manufacturers ◽  
Percent Confidence Level ◽  
Allowable Error

A practical procedure for sterility testing of intravenous admixtures contained in plastic bags using membrane filtration was developed. This technique was then evaluated in a pilot study involving 140 (18 percent) of the large volume intravenous admixtures prepared during June, 1972, by a central pharmacy admixture program. The technique was effective in detecting all of the positive controls, intentionally contaminated, in the pilot study. The pilot study furnished the necessary data to statistically determine a monthly sample size of intravenous admixtures to be cultured, which would represent the entire population at a 95 percent confidence level with a 5 percent allowable error of the mean, and to implement a program of routine sterility monitoring by the hospital's Epidemiology Department. Procedures involved in maintaining sterility in a centralized intravenous admixture program were also implemented and are discussed. Results of this study indicate that a program of routine sterility monitoring of a hospital pharmacy intravenous admixture program can be implemented simply and practically. The program would monitor potential contamination from both the pharmacy and pharmaceutical manufacturers.

Sterility Testing of Fat Emulsions Using Membrane Filtration and Dimethyl Sulfoxide

1982 ◽  
Vol 71 (6) ◽  
pp. 704-705 ◽  
Author(s):  
A.M. Placencia ◽  
G.S. Oxborrow ◽  
J.W. Danielson
Keyword(s):  
Dimethyl Sulfoxide ◽  
Membrane Filtration ◽  
Sterility Testing ◽  
Fat Emulsions

scholarly journals Water quality control trials: statistical tables for direct comparison between membrane filtration bacterial counts and the multiple tube method with a description of the bacteriological method

1988 ◽  
Vol 101 (2) ◽  
pp. 361-366 ◽  
Author(s):  
Hilary E. Tillett ◽  
A. E. Wright ◽  
Sheila Eaton
Keyword(s):  
Public Health ◽  
Escherichia Coli ◽  
Quality Control ◽  
Membrane Filtration ◽  
Water Industry ◽  
Water Quality Control ◽  
Laboratory Service ◽  
The Public ◽  
The United Kingdom ◽  
Bacteriological Method

SUMMARYExperiments in the quality control of water samples are being conducted in the Public Health Laboratory Service and the water industry in the United Kingdom. The number of distributions which have been made is 7 and 92 laboratories are now participating. The methods used for preparing and distributing samples are described. Some participating laboratories use the multiple tube method and some use membrane filtration to assess the presence of coliforms and Escherichia coli. The results are, therefore, a mixture of estimated numbers and direct colony counts.

Collaborative Study of Aerobic Media for Sterility Testing by Membrane Filtration

1971 ◽  
Vol 60 (7) ◽  
pp. 1087-1088 ◽  
Author(s):  
Frances W. Bowman ◽  
Mack White ◽  
Miriam P. Calhoun
Keyword(s):  
Membrane Filtration ◽  
Collaborative Study ◽  
Sterility Testing

scholarly journals Compounding Parenteral Products in Pediatric Wards—Effect of Environment and Aseptic Technique on Product Sterility

Healthcare ◽  
2021 ◽  
Vol 9 (8) ◽  
pp. 1025
Author(s):  
Sonja Virtanen ◽  
Karmen Kapp ◽  
Maria Rautamo ◽  
Lotta Schepel ◽  
Carita Lindén-Lahti ◽  
...  
Keyword(s):  
Membrane Filtration ◽  
Microbial Contamination ◽  
Pediatric Nurses ◽  
Patient Room ◽  
Aseptic Technique ◽  
Sterility Testing ◽  
Biological Safety ◽  
Clinical Environments ◽  
Parenteral Products ◽  
Parenteral Product

Parenteral products must be compounded using an aseptic technique to ensure sterility of the medicine. We compared the effect of three clinical environments as compounding areas as well as different aseptic techniques on the sterility of the compounded parenteral product. Clinical pharmacists and pediatric nurses compounded 220 samples in total in three clinical environments: a patient room, a medicine room and biological safety cabinet. The study combined four methods: observation, environmental monitoring (settle plates), monitoring of personnel (finger dab plates) and sterility testing (membrane filtration). Of the compounded samples, 99% were sterile and no significant differences emerged between the clinical environments. Based on the settle plates, the biological safety cabinet was the only area that fulfilled the requirements for eliminating microbial contamination. Most of the steps on the observation form for aseptic techniques were followed. All participants disinfected their hands, wore gloves and disinfected the septum of the vial. Non-contaminated finger dab plates were mostly detected after compounding in the biological safety cabinet. Aseptic techniques were followed relatively well in all environments. However, these results emphasize the importance of good aseptic techniques and support the recommendation of compounding parenteral products in biological safety cabinets in clinical environments.

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