Particle-Size Requirements Related to Content Uniformity of Solid Dosage Forms

1974 ◽  
Vol 63 (12) ◽  
pp. 1961-1963 ◽  
Author(s):  
M.C.R. Johnson
Keyword(s):  
Particle Size ◽  
Dosage Forms ◽  
Content Uniformity ◽  
Solid Dosage Forms ◽  
Solid Dosage

A statistical support for using spectroscopic methods to validate the content uniformity of solid dosage forms

2003 ◽  
Vol 92 (7) ◽  
pp. 1526-1530 ◽  
Author(s):  
Tonglei Li ◽  
Amy D. Donner ◽  
Candice Y. Choi ◽  
Gerard P. Frunzi ◽  
Kenneth R. Morris
Keyword(s):  
Dosage Forms ◽  
Content Uniformity ◽  
Spectroscopic Methods ◽  
Solid Dosage Forms ◽  
Solid Dosage ◽  
Statistical Support

scholarly journals Polyvinyl Alcohol-Based 3D Printed Tablets: Novel Insight into the Influence of Polymer Particle Size on Filament Preparation and Drug Release Performance

2021 ◽  
Vol 14 (5) ◽  
pp. 418
Author(s):  
Andrea Gabriela Crișan ◽  
Alina Porfire ◽  
Rita Ambrus ◽  
Gábor Katona ◽  
Lucia Maria Rus ◽  
...  
Keyword(s):  
Particle Size ◽  
Drug Release ◽  
Polyvinyl Alcohol ◽  
Fused Deposition Modeling ◽  
Dosage Forms ◽  
Solid Dosage Forms ◽  
Manufacturing Method ◽  
Solid Dosage ◽  
Fused Deposition ◽  
3D Printed

Three-dimensional printing (3DP) by fused deposition modeling (FDM) has gained momentum as a promising pharmaceutical manufacturing method due to encouraging forward-looking perspectives in personalized medicine preparation. The current challenges the technology has for applicability in the fabrication of solid dosage forms include the limited range of suitable pharmaceutical grade thermoplastic materials. Hence, it is important to investigate the implications of variable properties of the polymeric carrier on the preparation steps and the final output, as versatile products could be obtained by using the same material. In this study, we highlighted the influence of polyvinyl alcohol (PVA) particle size on the residence time of the mixtures in the extruder during the drug-loaded filament preparation step and the consequent impact on drug release from the 3D printed dosage form. We enhanced filament printability by exploiting the plasticizing potential of the active pharmaceutical ingredient (API) and we explored a channeled tablet model as a design strategy for dissolution facilitating purposes. Our findings disclosed a new perspective regarding material considerations for the preparation of PVA-based solid dosage forms by coupling hot melt extrusion (HME) and FDM-3DP.

scholarly journals Ultrasound-assisted powder-coating technique to improve content uniformity of low-dose solid dosage forms

2010 ◽  
Vol 11 (3) ◽  
pp. 1320-1327 ◽  
Author(s):  
Natalja Genina ◽  
Heikki Räikkönen ◽  
Osmo Antikainen ◽  
Jyrki Heinämäki ◽  
Jouko Yliruusi
Keyword(s):  
Low Dose ◽  
Powder Coating ◽  
Dosage Forms ◽  
Content Uniformity ◽  
Solid Dosage Forms ◽  
Coating Technique ◽  
Solid Dosage ◽  
Ultrasound Assisted
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