Effects of short-term dietary exposure to polychlorinated biphenyls on pharmacokinetics of intravenous pentobarbital in rats

AbstractPolychlorinated biphenyls (PCBs) were added to certain marine vessel bottom paints as a plasticizer to improve the adhesion and durability of the paint. The most common PCB formulation used to amend such paints was Aroclor 1254. Fugitive Aroclor-containing paint chips generated from vessel maintenance and repair operations represent a potential source of PCB contamination to sediments. Limited published studies indicate that Aroclor-containing paint is largely inert and exhibits low PCB leaching into water; however, the rate and degree of leaching of PCBs from paint chips have not been directly studied. This laboratory-based study evaluated the rate and extent of leaching of PCBs from paint chips into freshwater. The results of this investigation demonstrate that the rate of PCB dissolution from paint chips decreased rapidly and exponentially over time. Based on this study, it is estimated that the rate of leaching of PCBs from paint chips would cease after approximately 3 years of exposure to water. When all leachable PCBs were exhausted, it is estimated that less than 1% of the mass of PCBs in the paint chips was amenable to dissolution. The results of this experiment suggest that Aroclor-containing paint chips found in sediments are likely short-term sources of dissolved-phase PCB to pore or surface waters and that the majority of the PCBs in paint chips remain in the paint matrix and unavailable for partitioning into water. Graphic Abstract

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Effect of short-term dietary exposure on metal assimilation and metallothionein induction in the estuarine fish Pseudogobius sp.

The Science of The Total Environment ◽

10.1016/j.scitotenv.2021.145042 ◽

2021 ◽

Vol 772 ◽

pp. 145042

Author(s):

Sarah McDonald ◽

Kathryn Hassell ◽

Tom Cresswell

Keyword(s):

Dietary Exposure ◽

Estuarine Fish ◽

Short Term

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Validation of questionnaire-based long-term dietary exposure to polychlorinated biphenyls using biomarkers

Molecular Nutrition & Food Research ◽

10.1002/mnfr.201200196 ◽

2012 ◽

Vol 56 (11) ◽

pp. 1748-1754 ◽

Cited By ~ 23

Author(s):

Charlotte Bergkvist ◽

Agneta Åkesson ◽

Anders Glynn ◽

Karl Michaëlsson ◽

Panu Rantakokko ◽

...

Keyword(s):

Polychlorinated Biphenyls ◽

Dietary Exposure ◽

Validation Of Questionnaire

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Free-range eggs from a very polluted site in central Italy: levels of Polychlorinated Dibenzo-p-Dioxins/Furans and Polychlorinated Biphenyls and estimated human dietary exposure

Journal of Food Protection ◽

10.4315/jfp-21-126 ◽

2021 ◽

Author(s):

Federica Castellani ◽

Lamberto Manzoli ◽

Cecilia Acuti Martellucci ◽

Maria Elena Flacco ◽

Maria Luisa Astolfi ◽

...

Keyword(s):

Polychlorinated Biphenyls ◽

Central Italy ◽

Dietary Exposure ◽

Contamination Level ◽

Free Range ◽

Weekly Intake ◽

Tolerable Weekly Intake ◽

Commission Regulation ◽

Contamination Levels ◽

A Site

The aim of the present study was to evaluate the contamination levels of some classes of persistent organic pollutants (POPs) in free-range hen eggs and to estimate the related human dietary exposure in a Site of National Interest (SNI), characterized by a serious state of environmental pollution (Bussi sul Tirino area, central Italy). For these purposes, 17 samples of free-range hen eggs collected in home-producing farms located in the SNI territory were analyzed for 17 polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs), 12 dioxin-like polychlorinated biphenyls (dl-PCBs) and 6 non-dioxin-like PCBs (ndl-PCBs). Dietary exposure was assessed assuming a standard consumption of eggs per week. The concentration of ∑PCDD/Fs + dl-PCBs ranged from 0.463 to 8.028 pg TEQ (Toxic Equivalent) g−1 fat, while the mean contamination level of the ∑ndl-PCBs ranged from 0.234 to 7.741 ng TEQ g−1 fat. PCDD/Fs and PCBs contamination levels were lower than maximum values established by the Commission Regulation (EU) 1259/2011, except for one sample. The estimated weekly intake (EWI), calculated in order to evaluate the contribution in terms of the monitored pollutants of the locally produced eggs to the diet, was lower than the tolerable weekly intake (TWI) established by the European Food Safety Authority (EFSA).

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