The structure‐activity mechanism of the changes in the physicochemical properties of Flammulina velutipes polysaccharides during ultrasonic extraction

Author(s):  
Xin Chen ◽  
Liyan Zhao ◽  
Qiuhui Hu ◽  
Jinrong Xiao ◽  
Benard Muinde Kimatu ◽  
...  
2018 ◽  
Author(s):  
Daniel A. Estabrook ◽  
Amanda F. Ennis ◽  
Rachael Day ◽  
Ellen Sletten

Emulsions are dynamic materials that have been extensively employed within pharmaceutical, food and cosmetics industries. However, their use beyond conventional applications has been hindered by difficulties in surface functionalization, and an inability to selectively control physicochemical properties. Here, we employ custom poly(2-oxazoline) block copolymers to overcome these limitations. We demonstrate that poly(2-oxazoline) copolymers can effectively stabilize nanoscale droplets of hydrocarbon and perfluorocarbon in water. The living polymerization allows for the incorporation of chemical handles into the surfactants such that covalent modification of the emulsion surfaces can be performed. Through post-emulsion modification, we are able to access nanoemulsions with modified surface chemistries, yet consistent sizes. By decoupling size and surface charge, we explore structure-activity relationships involving the cellular uptake of nanoemulsions.


2020 ◽  
Vol 510 ◽  
pp. 112484 ◽  
Author(s):  
Sabahat Sardar ◽  
Asad Mumtaz ◽  
Mehwish Taneez ◽  
Masoom Yasinzai ◽  
Muhammad Imran Irshad ◽  
...  

Antioxidants ◽  
2019 ◽  
Vol 8 (8) ◽  
pp. 298 ◽  
Author(s):  
Yu-Ning Hu ◽  
Tzu-Jung Sung ◽  
Chun-Hsu Chou ◽  
Kai-Lun Liu ◽  
Liang-Po Hsieh ◽  
...  

Yellow strain Flammulina velutipes, which is known as Jinhua mushroom in Taiwan, has become popular among customers due to its distinct texture that is utterly different from white strain F. velutipes. However, there has been little study on the physicochemical properties, antioxidant activities, and biological functions of yellow strain F. velutipes polysaccharides (FVYs). The specific aims of this study are to evaluate and compare the physicochemical properties, antioxidant activities, and biological functions of FVYs and white strain F. velutipes polysaccharides (FVWs) in order to select the strain appropriate for cosmetic ingredient. The FVYs and FVWs were prepared by fractional precipitation (40%, 60%, and 80%). According to the results, FVY-80 showed the greatest antioxidant activities based on 2,2-diphenyl-1-picrylhydrazyl (DPPH) (IC50 = 2.22 mg/mL) and 2,2’ -azino-bis-3-ethylbenzthiazoline-6-sulphonic acid (ABTS) radical assay (IC50 = 2.04 mg/mL). None of the fractions exhibited cytotoxicity toward L929 cell under a concentration of 500 μ g/mL. FVY-80 significantly reduced the reactive oxygen species (ROS) content in L929 cell by 55.96%, as compared with the H2O2-induced L929 cell, according to the dichloro-dihydro-fluorescein diacetate (DCFH-DA) assay. In conclusion, we suggest that FVY-80 is the best source for a cosmetics ingredient.


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