Surveillance for lung metastasis from giant cell tumor of bone

2017 ◽  
Vol 116 (7) ◽  
pp. 907-913 ◽  
Author(s):  
Mamer Rosario ◽  
Han-Soo Kim ◽  
Ji Yeon Yun ◽  
Ilkyu Han
Keyword(s):  
Giant Cell Tumor ◽  
Giant Cell ◽  
Lung Metastasis ◽  
Cell Tumor

scholarly journals Clinical characteristics and risk factors analysis of lung metastasis from benign giant cell tumor of bone

2017 ◽  
Vol 7 ◽  
pp. 23-28 ◽  
Author(s):  
Yongkun Yang ◽  
Zhen Huang ◽  
Xiaohui Niu ◽  
Hairong Xu ◽  
Yuan Li ◽  
...  
Keyword(s):  
Risk Factors ◽  
Giant Cell Tumor ◽  
Giant Cell ◽  
Lung Metastasis ◽  
Clinical Characteristics ◽  
Cell Tumor ◽  
Factors Analysis

scholarly journals Fatal lung metastasis secondary to index finger giant cell tumor in an 8-year-old child

2010 ◽  
Vol 96 (3) ◽  
pp. 310-313 ◽  
Author(s):  
S. Jacopin ◽  
E. Viehweger ◽  
Y. Glard ◽  
F. Launay ◽  
J.-L. Jouve ◽  
...  
Keyword(s):  
Giant Cell Tumor ◽  
Giant Cell ◽  
Lung Metastasis ◽  
Index Finger ◽  
Cell Tumor

scholarly journals Prognostic significance of the preoperative neutrophil-to-lymphocyte ratio patients with giant cell tumor of bone

2021 ◽  
Vol 21 (3) ◽  
pp. 1250-1258
Author(s):  
Aliekber Yapar ◽  
Ismail Burak Atalay ◽  
Mehmet Ali Tokgoz ◽  
Coskun Ulucakoy ◽  
Bedii Safak Gungor
Keyword(s):  
Giant Cell Tumor ◽  
Giant Cell ◽  
Lung Metastasis ◽  
Prognostic Significance ◽  
Multivariable Analysis ◽  
Cell Tumor ◽  
Neutrophil To Lymphocyte Ratio ◽  
Receiver Operating Curve ◽  
Cox Regression Analysis ◽  
Lymphocyte Ratio

Objective: To evaluate the prognostic significance of neutrophil-to-lymphocyte ratio (NLR) in giant cell tumor of bone (GCT). Methods: The patients with GCT were identified in the hospital records and pre-treatment complete blood count results were acquired retrospectively. Whether preoperative NLR lymphocyte-to-monocyte ratio (LMR) and platelet-to-lymphocyte ratio (PLR) values had prognostic significance in predicting recurrence was evaluated by Receiver operating curve (ROC) analysis. Furthermore, the prognostic value of NLR was evaluated by Multivariable Cox Regression analysis. Results: There were 96 patients with GCT. It was found that only NLR values had prognostic significance for predicting recurrence (AUC:0.647; 95% CI:0.533-0.762; P=0.021). The statistically significant cut-off value of NLR for predicting re- currence was ≥2.25.NLR was ≥2.25 in 51% (n = 49) of patients. Multivariable analysis showed that NLR ≥2.25 (HR=2.9, 95% CI:1.3-6.6; p=0.009) and lung metastasis (HR=7.9, 95% CI:2.2-28.2; p=0.001) were independent factors of recurrence. In patients with lung metastasis and patients with NLR ≥2.25, recurrence was observed in a sooner period (Log rank test; p=0.001; p=0.009, respectively). Conclusion: Our findings showed that NLR is a new and promising inflammation-based prognostic factor in GCT patients. Keywords: Giant cell tumor of bone; neutrophil-to-lymphocyte ratio; prognostic significance.

A lung metastasis from giant cell tumor of bone at eight years after primary resection

1999 ◽  
Vol 47 (12) ◽  
pp. 617-620 ◽  
Author(s):  
Keiko Kitano ◽  
Takeshi Shiraishi ◽  
Kan Okabayashi ◽  
Akinori Iwasaki ◽  
Katsunobu Kawahara ◽  
...  
Keyword(s):  
Giant Cell Tumor ◽  
Giant Cell ◽  
Lung Metastasis ◽  
Primary Resection ◽  
Cell Tumor

scholarly journals EFEMP1 as a Potential Biomarker for Diagnosis and Prognosis of Osteosarcoma

2020 ◽  
Vol 2020 ◽  
pp. 1-9
Author(s):  
Zhuo Wang ◽  
Jihui Kang ◽  
Jiayan Lian ◽  
Leilei Huang ◽  
Wenlin Xie ◽  
...  
Keyword(s):  
Tumor Progression ◽  
Giant Cell Tumor ◽  
Giant Cell ◽  
Lung Metastasis ◽  
Matrix Protein ◽  
Cell Tumor ◽  
Extracellular Matrix Protein ◽  
Control Group ◽  
Diagnosis And Prognosis ◽  
Potential Biomarker

Osteosarcoma (OS) is the most common primary bone malignancy. Our previous study revealed an association between the level of epidermal growth factor-containing fibulin-like extracellular matrix protein 1 (EFEMP1) and the invasion, metastasis, and poor prognosis of OS. However, the exact correlation between the serum EFEMP1 level and OS diagnosis and progression was unclear. This study is aimed at determining the value of the serum EFEMP1 level in the diagnosis and prognosis of OS. Fifty-one consecutive OS patients were prospectively registered in this study. The serum EFEMP1 levels were measured using ELISA at diagnosis, after neoadjuvant chemotherapy, and before and after surgical treatment. Sixty-nine healthy subjects in the control group, nine patients with chondrosarcoma, and 12 patients with giant cell tumor of the bone were also enrolled in this study. Surgical orthotopic implantation was used to generate a mouse OS model, and the correlation between the circulating EFEMP1 levels and tumor progression was examined. Then, OS patients had significantly higher mean serum EFEMP1 levels (7.61 ng/ml) than the control subjects (1.47 ng/ml). The serum EFEMP1 levels were correlated with the Enneking staging system (r=0.32, P=0.021) and lung metastasis (r=0.50, P<0.001). There was also a correlation between the serum EFEMP1 level and EFEMP1 expression in the respective OS samples (r=0.49, P<0.001). Additionally, patients with either chondrosarcoma or giant cell tumor of the bone had significantly higher serum EFEMP1 levels than OS patients. Surgical and chemotherapeutic treatment led to an increase in the serum EFEMP1 levels. Then, the destruction of bone tissues might be one of the factors about the EFEMP1 levels. In the mouse OS model, the serum EFEMP1 level was correlated with tumor progression. Our results suggested that serum EFEMP1 levels might be used to distinguish OS patients from healthy controls and as an indicator for OS lung metastasis. Serum EFEMP1 levels could serve as a new and assisted biomarker for the auxiliary diagnosis and prognosis of OS.

scholarly journals Giant cell tumor in queer location with lung metastasis!

2021 ◽  
pp. 101554
Author(s):  
Rupali Jain ◽  
Chandrashekhara Sh ◽  
Asit Ranjan Mridha
Keyword(s):  
Giant Cell Tumor ◽  
Giant Cell ◽  
Lung Metastasis ◽  
Cell Tumor

A case of recurrent giant cell tumor with lung metastasis during pregnancy

2010 ◽  
Vol 3 (2) ◽  
pp. 72
Author(s):  
Kicheol Kil ◽  
Jinyoung Yoo ◽  
Sun-Young Nam ◽  
Jae-Eun Chung ◽  
Young Lee
Keyword(s):  
Giant Cell Tumor ◽  
Giant Cell ◽  
Lung Metastasis ◽  
Cell Tumor ◽  
Recurrent Giant Cell Tumor

Giant cell tumor of the tendon sheath involving skin

1978 ◽  
Vol 114 (6) ◽  
pp. 944-946 ◽  
Author(s):  
D. T. King
Keyword(s):  
Giant Cell Tumor ◽  
Giant Cell ◽  
Tendon Sheath ◽  
Cell Tumor

Bilateral Mirror-Symmetrical Giant Cell Tumor of the Tendon Sheath in the Foot and Ankle: A Case Report

2021 ◽  
Vol 60 (1) ◽  
pp. 163-166
Author(s):  
Naji S. Madi ◽  
Said Saghieh ◽  
Ahmad Salah Naja ◽  
Rachid K. Haidar
Keyword(s):  
Case Report ◽  
Giant Cell Tumor ◽  
Giant Cell ◽  
Tendon Sheath ◽  
Cell Tumor ◽  
Foot And Ankle
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