scholarly journals Prognostic significance of the preoperative neutrophil-to-lymphocyte ratio patients with giant cell tumor of bone

2021 ◽  
Vol 21 (3) ◽  
pp. 1250-1258
Author(s):  
Aliekber Yapar ◽  
Ismail Burak Atalay ◽  
Mehmet Ali Tokgoz ◽  
Coskun Ulucakoy ◽  
Bedii Safak Gungor
Keyword(s):  
Giant Cell Tumor ◽  
Giant Cell ◽  
Lung Metastasis ◽  
Prognostic Significance ◽  
Multivariable Analysis ◽  
Cell Tumor ◽  
Neutrophil To Lymphocyte Ratio ◽  
Receiver Operating Curve ◽  
Cox Regression Analysis ◽  
Lymphocyte Ratio

Objective: To evaluate the prognostic significance of neutrophil-to-lymphocyte ratio (NLR) in giant cell tumor of bone (GCT). Methods: The patients with GCT were identified in the hospital records and pre-treatment complete blood count results were acquired retrospectively. Whether preoperative NLR lymphocyte-to-monocyte ratio (LMR) and platelet-to-lymphocyte ratio (PLR) values had prognostic significance in predicting recurrence was evaluated by Receiver operating curve (ROC) analysis. Furthermore, the prognostic value of NLR was evaluated by Multivariable Cox Regression analysis. Results: There were 96 patients with GCT. It was found that only NLR values had prognostic significance for predicting recurrence (AUC:0.647; 95% CI:0.533-0.762; P=0.021). The statistically significant cut-off value of NLR for predicting re- currence was ≥2.25.NLR was ≥2.25 in 51% (n = 49) of patients. Multivariable analysis showed that NLR ≥2.25 (HR=2.9, 95% CI:1.3-6.6; p=0.009) and lung metastasis (HR=7.9, 95% CI:2.2-28.2; p=0.001) were independent factors of recurrence. In patients with lung metastasis and patients with NLR ≥2.25, recurrence was observed in a sooner period (Log rank test; p=0.001; p=0.009, respectively). Conclusion: Our findings showed that NLR is a new and promising inflammation-based prognostic factor in GCT patients. Keywords: Giant cell tumor of bone; neutrophil-to-lymphocyte ratio; prognostic significance.

Surveillance for lung metastasis from giant cell tumor of bone

2017 ◽  
Vol 116 (7) ◽  
pp. 907-913 ◽  
Author(s):  
Mamer Rosario ◽  
Han-Soo Kim ◽  
Ji Yeon Yun ◽  
Ilkyu Han
Keyword(s):  
Giant Cell Tumor ◽  
Giant Cell ◽  
Lung Metastasis ◽  
Cell Tumor

scholarly journals Clinical characteristics and risk factors analysis of lung metastasis from benign giant cell tumor of bone

2017 ◽  
Vol 7 ◽  
pp. 23-28 ◽  
Author(s):  
Yongkun Yang ◽  
Zhen Huang ◽  
Xiaohui Niu ◽  
Hairong Xu ◽  
Yuan Li ◽  
...  
Keyword(s):  
Risk Factors ◽  
Giant Cell Tumor ◽  
Giant Cell ◽  
Lung Metastasis ◽  
Clinical Characteristics ◽  
Cell Tumor ◽  
Factors Analysis

scholarly journals Fatal lung metastasis secondary to index finger giant cell tumor in an 8-year-old child

2010 ◽  
Vol 96 (3) ◽  
pp. 310-313 ◽  
Author(s):  
S. Jacopin ◽  
E. Viehweger ◽  
Y. Glard ◽  
F. Launay ◽  
J.-L. Jouve ◽  
...  
Keyword(s):  
Giant Cell Tumor ◽  
Giant Cell ◽  
Lung Metastasis ◽  
Index Finger ◽  
Cell Tumor

A lung metastasis from giant cell tumor of bone at eight years after primary resection

1999 ◽  
Vol 47 (12) ◽  
pp. 617-620 ◽  
Author(s):  
Keiko Kitano ◽  
Takeshi Shiraishi ◽  
Kan Okabayashi ◽  
Akinori Iwasaki ◽  
Katsunobu Kawahara ◽  
...  
Keyword(s):  
Giant Cell Tumor ◽  
Giant Cell ◽  
Lung Metastasis ◽  
Primary Resection ◽  
Cell Tumor

scholarly journals Prognostic value of the dynamic change of platelets to lymphocytes ratio and neutrophil to lymphocyte ratio for gastric cancer patients receiving curative surgery.

2020 ◽  
Author(s):  
Shiva Basnet ◽  
Nan Liu ◽  
Qixin Jiang ◽  
Hai Dan Lan ◽  
Mamata Khadka ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Prognostic Factors ◽  
Categorical Data ◽  
Neutrophil To Lymphocyte Ratio ◽  
Receiver Operating Curve ◽  
P Value ◽  
Survival Prediction ◽  
Cox Regression Analysis ◽  
Lymphocyte Ratio ◽  
Post Surgery

Abstract Background: The inflammatory biomarkers play a prominent role in tumorigenesis and progression of gastric cancer. Inflammatory response has shown to be promising candidate for monitoring the survival prediction in various cancer. Certain percent of cancer related deaths are closely associated with chronic inflammation. Our study aims to focus a precise estimation on the prognostic significance of preoperative Neutrophil to Lymphocyte ratio (NLR), Platelets to Lymphocyte ratio (PLR), derived Neutrophil to Lymphocyte ratio (ΔNLR) and derived Platelet to Lymphocyte ratio (ΔPLR) following gastric cancer.Methods: A retrospective analysis was conducted in patients with gastric cancer in Shanghai East Hospital affiliated with Tong ji University between December 2012 and June 2015, and total 145 patients were identified eligible. NLR, PLR, Δ NLR and ΔPLR values were calculated from peripheral blood cell count taken before surgery and 6-month post-surgery. Optimal cutoff value was determined by Receiver operating curve (ROC). Kaplan-Meier analysis was used to calculate the overall survival (OS) and Recurrence Free Survival (RFS). Cox regression analysis was performed to assess the prognostic factors. Continuous data with normal distribution was presented as mean ± standard deviation, and non-parametrical data were presented as median with interquartile range (IQR). Categorical data was described by frequency. The Student’s t test or one-way ANOVA (Analysis of Variance) was used for comparing continuous variables whereas Fisher’s exact test or χ2 test was used for categorical dataResults: The median follow-up duration was 26 months (IQR, 17–35). Patients were stratified in two groups by NLR (≤ 2.9,>2.9) and PLR (≤ 147,>147).3 years RFS of low ΔNLR and high ΔNLR is 59.0% and 76.7% respectively. Similarly, RFS of low ΔPLR and high ΔPLR group is 58.0% and 76.2%respectively. Multivariate analysis reviled elevated PLR [HR = 1.008,95%CI = 1.002–1.014, P-value = 0.011, for OS and HR = 1.009,95%CI = 1.004–1.014, P-value = 0.001, for RFS] and ΔPLR [HR = .994,95%CI = 0.990–0.999, P-value = 0.016 for OS and HR = 0.991 95%CI = 0.987–0.996 P-value = < 0.001 for RFS] were significantly associated with OS and RFS.Conclusions: Pre-operative PLR and derived(ΔPLR) are independent prognostic factors of OS and RFS in Gastric Cancer (GC) patients undergoing radical gastrectomy. The reduction of PLR and NLR after surgery might be helpful to predict cancer recurrence in patients who have undergone gastrectomy.

Neutrophil-to-lymphocyte ratio as a predictor of oncologic outcomes in locally advanced non-metastatic clear cell renal carcinoma.

2020 ◽  
Vol 38 (6_suppl) ◽  
pp. 661-661
Author(s):  
Gilberto Rodrigues ◽  
Pablo Sierra ◽  
Emanuel Albuquerque ◽  
Fabio Pescarmona Gallucci ◽  
Eder Nisi Ilario ◽  
...  
Keyword(s):  
Cox Regression ◽  
Clear Cell ◽  
Locally Advanced ◽  
Multivariable Analysis ◽  
Neutrophil To Lymphocyte Ratio ◽  
Nuclear Grade ◽  
Oncologic Outcomes ◽  
Receiver Operating Curve ◽  
Lymphocyte Ratio ◽  
Metastatic Setting

661 Background: An elevated neutrophil-to-lymphocyte ratio (NLR) has been associated with worse oncologic outcomes in several malignancies, its prognostic role in kidney cancer, specifically in the non metastatic setting is controversial. We aimed to evaluate if an elevated NLR in patients with locally advanced non metastatic clear cell renal cell carcinoma (CCRCC) is associated with a worse survival and/or a higher cancer recurrence rate. Methods: We retrospectively identified 880 nephrectomies performed between 01/2009 to 12/2016 in a single center, reviewed data from 478 consecutive radical nephrectomies (RN) for kidney tumors and identified 187 patients with locally advanced non-metastatic CCRCC patients (pT3-T4 N0M0). The cut-off point of NLR = 2.5 was obtained using the receiver operating curve analysis (ROC). NLR was obtained preoperatively and calculated by dividing absolute neutrophil count by absolute lymphocyte count. Overall survival (OS) and recurrence-free survival (RFS) were evaluated using the Kaplan-Meier method. Cox regression models were utilized to evaluate predictors of recurrence and survival. Results: Median follow up was 48.7 months. The 3 year OS was significantly lower for patients with NLR ≥ 2.5 than those with NLR < 2.5 (70% vs 85%, p = 0.049). In patients with a Fuhrman nuclear grade of differentiation of 3-4, the median time to recurrence was significantly shorter for patients with NLR ≥ compared to those with NLR < 4 (24 vs 55 months p 0.045). On multivariable analysis adjusted for NLR ≥ 2.5, microvascular invasion, sarcomatoid differentiation, tumor size and body mass index, only nuclear grade of differentiation was found to be an independent predictor for recurrence (hazard ratio= 2.18; 95% confidence interval [CI]: 1.07 – 4.92, p = 0.03). Conclusions: Patients with non-metastatic CCRCC with higher nuclear grade of differentiation and a high preoperative NLR have shorter RFS and worse OS compared to patients with lower NLR.

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