Validation of the eighth edition AJCC staging system in early T1 to T2 oral squamous cell carcinoma

2018 ◽  
Vol 119 (4) ◽  
pp. 449-454 ◽  
Author(s):  
Samskruthi Murthy ◽  
Tsu-Hui Hubert Low ◽  
Narayana Subramaniam ◽  
Deepak Balasubramanian ◽  
Vidhyadharan Sivakumaran ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Staging System ◽  
Ajcc Staging System ◽  
Eighth Edition ◽  
Ajcc Staging

scholarly journals Survival Rates of Sinonasal Squamous Cell Carcinoma With the New AJCC Staging System

2007 ◽  
Vol 133 (2) ◽  
pp. 131 ◽  
Author(s):  
Chul Hee Lee ◽  
Dong Gu Hur ◽  
Hwan-Jung Roh ◽  
Ki-Sang Rha ◽  
Hong-Ryul Jin ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Survival Rates ◽  
Staging System ◽  
Ajcc Staging System ◽  
Ajcc Staging

scholarly journals Impact of HPV Status on the Prognostic Potential of the AJCC Staging System for Larynx Cancer

2018 ◽  
Vol 159 (3) ◽  
pp. 456-465 ◽  
Author(s):  
Stacey M. Davidson ◽  
Huasing C. Ko ◽  
Paul M. Harari ◽  
Aaron M. Wieland ◽  
Shuai Chen ◽  
...  
Keyword(s):  
Overall Survival ◽  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Laryngeal Squamous Cell Carcinoma ◽  
Staging System ◽  
National Cancer Database ◽  
Hpv Status ◽  
Ajcc Staging System ◽  
Ajcc Staging

Objective We evaluated the ability of the American Joint Committee on Cancer (AJCC) seventh edition staging system to prognosticate the overall survival of patients with human papillomavirus (HPV)–positive laryngeal squamous cell carcinoma. Study Design Retrospective analysis. Setting National Cancer Database. Subjects and Methods Patients diagnosed with laryngeal squamous cell carcinoma who were treated with curative intent were identified in the National Cancer Database. Multivariate analysis was utilized to determine factors correlated with overall survival in the HPV-negative and HPV-positive cohorts. Unadjusted and propensity score–weighted Kaplan-Meier estimation was used to determine overall survival of HPV-negative and HPV-positive patients across AJCC stage groupings. Results We identified 3238 patients with laryngeal squamous cell carcinoma, of which 2812 were HPV negative and 426 were HPV positive. Overall survival adjusted for age, sex, and comorbidity status confirmed significant differences among all consecutive stage groupings (I vs II, P < .001; II vs III, P < .05; III vs IVA, P < .001; IVA vs IVB, P < .05) in the HPV-negative cohort, whereas only stages IVAs and IVB ( P < .01) exhibited a significant difference in overall survival for HPV-positive patients. Conclusion The current AJCC staging system does not accurately distinguish risk of mortality for patients with HPV-positive disease. These data support the consideration of HPV status in estimating prognosis as well as clinical trial design and clinical decision making for patients with laryngeal squamous cell carcinoma.

scholarly journals Prognostic Exploration of All-Cause Death in Gingival Squamous Cell Carcinoma: A Retrospective Analysis of 2076 Patients

2021 ◽  
Vol 2021 ◽  
pp. 1-11
Author(s):  
Shuai Zheng ◽  
Jin Yang ◽  
Chengzhuo Li ◽  
Didi Han ◽  
Fengshuo Xu ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Staging System ◽  
Tumor Grade ◽  
Histological Subtype ◽  
Ajcc Stage ◽  
Ajcc Staging System ◽  
Gingival Squamous Cell Carcinoma ◽  
Ajcc Staging

Background. We aimed to establish a prognostic model for gingival squamous cell carcinoma (GSCC) that was superior to traditional AJCC staging and to perform a comprehensive comparison of the newly established nomogram with the AJCC staging system. Methods. We extracted 2,076 patients with gingival squamous cell carcinoma who had been entered into the SEER (Surveillance, Epidemiology, and End Results) database between 2004 and 2015, and randomly divided 70% of them into the training cohort and the other 30% into the validation cohort. Cox regression analysis was performed in combination with clinical experience and age, race, sex, marital status, tumor location, histological subtype, tumor grade, AJCC stage, chemotherapy status, radiotherapy status, and surgery status as possible prognostic factors. We evaluated and compared the two cohorts using the consistency index (C-index), area under the receiver operating characteristic curves, calibration curves, discriminant improvement index, and decision-curve analysis. Results. The Cox retrospective analysis showed that age, AJCC stage, tumor grade, histological subtype, radiotherapy status, and surgery status were significant factors to include in the new model of gingival squamous cell carcinoma. The other indicators were also better for the new model than for the AJCC staging system. Conclusion. We have developed and validated a nomogram for performing reliable gingival squamous cell carcinoma prognoses. The prognostic value of the nomogram is higher than that of the AJCC staging system. We expect that the inclusion of more-comprehensive and authoritative data (i.e., not just limited to residents of the United States) would also allow the construction of reliable nomograms for other populations.

Prognostic implications of the 8th edition American Joint Committee on Cancer (AJCC) staging system in oral cavity squamous cell carcinoma

Oral Oncology ◽  
2018 ◽  
Vol 85 ◽  
pp. 82-86 ◽  
Author(s):  
Nikolaus Moeckelmann ◽  
Ardalan Ebrahimi ◽  
Ying K. Tou ◽  
Ruta Gupta ◽  
Tsu-Hui (Hubert) Low ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Cavity ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Staging System ◽  
American Joint Committee ◽  
Ajcc Staging System ◽  
Prognostic Implications ◽  
Ajcc Staging ◽  
8Th Edition

scholarly journals Nomogram for predicting cancer-specific survival of patients with buccal squamous cell carcinoma: a population-based study

2020 ◽  
Author(s):  
Wei-Ming Wang ◽  
xiuhong chu ◽  
sisi yang ◽  
ying wang ◽  
chuanyu hu
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Prognostic Value ◽  
Cox Regression ◽  
Staging System ◽  
Cancer Specific Survival ◽  
Ajcc Staging System ◽  
Ajcc Staging ◽  
Buccal Squamous Cell Carcinoma

Abstract Background The use of the traditional American Joint Committee on Cancer (AJCC) staging system alone has limitations in predicting the survival of buccal squamous cell carcinoma (BSCC) patients. We aimed to establish a comprehensive prognostic nomogram whose prognostic value compared with AJCC system. Methods Patients were obtained from the SEER (Surveillance, Epidemiology, and End Result) database. The Cox regression model was used to select variables using a backward stepwise selection method. Based on the predictive model for determining prognostic factors, a nomogram was developed to predict the cancer-specific survival rates of BSCC patients at 3, 5 and 8 years. We used several standard model validation methods to evaluate the performance of the survival model: concordance index (C-index), area under the time-dependent receiver operating characteristic curve (AUC), net reclassification improvement (NRI), calibration plots, decision curve analyses (DCAs), and integrated discrimination improvement (IDI). Results Multivariate analysis showed that age, AJCC stage, N stage, M stage, pathological grade, and surgical status were risk factors for survival. The c-index chart, the AUC chart, and the calibration chart show that the performance of the nomogram is better, and the NRI and IDI values show that the performance of the nomogram is better than that of the AJCC staging system. The 3-year, 5-year and 8-year DCA curves of nomogram show that it has more net benefit than traditional AJCC staging system, both in terms of training and validation queues. Conclusion We developed and validated the first BSCC prognosis nomogram, which has a better prognostic value than the separate AJCC staging system. Our BSCC prognosis nomogram is a valuable tool for explaining the risks of the next 3, 5 and 8 years in clinical practice.

scholarly journals Application of the eighth edition of the American joint committee on cancer staging system for oral carcinoma

2019 ◽  
Vol 72 (5-6) ◽  
pp. 165-170
Author(s):  
Ivana Mijatov ◽  
Sasa Mijatov
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Maxillofacial Surgery ◽  
Staging System ◽  
Nodal Status ◽  
Oral Carcinoma ◽  
Significant Shift ◽  
8Th Edition

Introduction. Oral squamous cell carcinoma is the sixth most common carcinoma in the world. Annually, it accounts for 5% of all newly discovered cancers. The most important prognostic factor is the stage of the disease. The tumor, node, and metastasis staging system has been the cornerstone for clinical classification of oral squamous cell carcinoma. Material and Methods. The study included 65 patients with oral squamous cell carcinoma who underwent surgery at the Clinic of Maxillofacial Surgery of the Clinical Center of Vojvodina in Novi Sad. The tumor, node, and metastasis status was determined according to 7th and 8th edition of the tumor, node, and metastasis classification. Results. Statistical differences between the 7th and 8th edition of tumor, node, and metastasis classification were examined. There was also a change in the nodal status; in 20% of patients there was a transition from N1 to N2, as a result of a more precise definition of nodal status in patients with oral carcinoma. Conclusion. This research has pointed out the significance of tumor size as a predictive factor in oral squamous cell carcinoma, which indicates the importance of its local control (for surgical and radiological treatment). The 8th edition of the tumor, node, and metastasis classification for oral cavity cancers made a significant shift by clearly defining depth of tumor invasion into the tumor status.

scholarly journals Perineural Invasion in Oral Squamous Cell Carcinoma in Relation to Tumor Depth

2019 ◽  
Vol 31 (2) ◽  
pp. 1-6
Author(s):  
Farah S Rasheed ◽  
Bashar H Abdullah
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Perineural Invasion ◽  
Staging System ◽  
Depth Of Invasion ◽  
Tumor Depth ◽  
Size Category ◽  
Significant Difference

Background: The American Joint committee on Cancer in their 8th edition staging manual regarded perineural invasion as one of the most important prognostic factors for Lip and Oral Cavity Squamous Cell Carcinoma, it also incorporated tumor depth of invasion in defining tumor size category in the new staging system. This study was conducted to evaluate the frequency of perineural invasion in oral squamous cell carcinoma and the effect of approaching tumor depth in this process. Materials and Methods: fifty-four formalin fixed paraffin embedded tissue blocks of radical resections of Oral Squamous Cell Carcinoma were cut and stained with Hematoxylin and Eosin stain, then evaluated for perineural invasion, with estimation of tumor depth of invasion for each case. Results: Perineural invasion was found in twenty-two cases of the study sample. The diameter of the largest nerve bundle that showed perineural invasion was found to have a positive significant correlation with tumor depth of invasion (p=0.025). Perineural invasion status in terms of (present, absent) showed a significant difference with patients’ age (p=0.037), also showed a significant association with tumor site (p=0.004), however, this association was non-significant in regard to tumor grade and stage (p=0.848, p=0.520) respectively. Conclusion: The attacking potential of preceding tumor depth and those cancers affecting young individuals may be reflected by the presence of neural infiltration by tumor cells. Tongue resected tumors should be carefully inspected for this deceptive biological process.

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