scholarly journals Prognostic Exploration of All-Cause Death in Gingival Squamous Cell Carcinoma: A Retrospective Analysis of 2076 Patients

2021 ◽  
Vol 2021 ◽  
pp. 1-11
Author(s):  
Shuai Zheng ◽  
Jin Yang ◽  
Chengzhuo Li ◽  
Didi Han ◽  
Fengshuo Xu ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Staging System ◽  
Tumor Grade ◽  
Histological Subtype ◽  
Ajcc Stage ◽  
Ajcc Staging System ◽  
Gingival Squamous Cell Carcinoma ◽  
Ajcc Staging

Background. We aimed to establish a prognostic model for gingival squamous cell carcinoma (GSCC) that was superior to traditional AJCC staging and to perform a comprehensive comparison of the newly established nomogram with the AJCC staging system. Methods. We extracted 2,076 patients with gingival squamous cell carcinoma who had been entered into the SEER (Surveillance, Epidemiology, and End Results) database between 2004 and 2015, and randomly divided 70% of them into the training cohort and the other 30% into the validation cohort. Cox regression analysis was performed in combination with clinical experience and age, race, sex, marital status, tumor location, histological subtype, tumor grade, AJCC stage, chemotherapy status, radiotherapy status, and surgery status as possible prognostic factors. We evaluated and compared the two cohorts using the consistency index (C-index), area under the receiver operating characteristic curves, calibration curves, discriminant improvement index, and decision-curve analysis. Results. The Cox retrospective analysis showed that age, AJCC stage, tumor grade, histological subtype, radiotherapy status, and surgery status were significant factors to include in the new model of gingival squamous cell carcinoma. The other indicators were also better for the new model than for the AJCC staging system. Conclusion. We have developed and validated a nomogram for performing reliable gingival squamous cell carcinoma prognoses. The prognostic value of the nomogram is higher than that of the AJCC staging system. We expect that the inclusion of more-comprehensive and authoritative data (i.e., not just limited to residents of the United States) would also allow the construction of reliable nomograms for other populations.

scholarly journals Survival Rates of Sinonasal Squamous Cell Carcinoma With the New AJCC Staging System

2007 ◽  
Vol 133 (2) ◽  
pp. 131 ◽  
Author(s):  
Chul Hee Lee ◽  
Dong Gu Hur ◽  
Hwan-Jung Roh ◽  
Ki-Sang Rha ◽  
Hong-Ryul Jin ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Survival Rates ◽  
Staging System ◽  
Ajcc Staging System ◽  
Ajcc Staging

scholarly journals Impact of HPV Status on the Prognostic Potential of the AJCC Staging System for Larynx Cancer

2018 ◽  
Vol 159 (3) ◽  
pp. 456-465 ◽  
Author(s):  
Stacey M. Davidson ◽  
Huasing C. Ko ◽  
Paul M. Harari ◽  
Aaron M. Wieland ◽  
Shuai Chen ◽  
...  
Keyword(s):  
Overall Survival ◽  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Laryngeal Squamous Cell Carcinoma ◽  
Staging System ◽  
National Cancer Database ◽  
Hpv Status ◽  
Ajcc Staging System ◽  
Ajcc Staging

Objective We evaluated the ability of the American Joint Committee on Cancer (AJCC) seventh edition staging system to prognosticate the overall survival of patients with human papillomavirus (HPV)–positive laryngeal squamous cell carcinoma. Study Design Retrospective analysis. Setting National Cancer Database. Subjects and Methods Patients diagnosed with laryngeal squamous cell carcinoma who were treated with curative intent were identified in the National Cancer Database. Multivariate analysis was utilized to determine factors correlated with overall survival in the HPV-negative and HPV-positive cohorts. Unadjusted and propensity score–weighted Kaplan-Meier estimation was used to determine overall survival of HPV-negative and HPV-positive patients across AJCC stage groupings. Results We identified 3238 patients with laryngeal squamous cell carcinoma, of which 2812 were HPV negative and 426 were HPV positive. Overall survival adjusted for age, sex, and comorbidity status confirmed significant differences among all consecutive stage groupings (I vs II, P < .001; II vs III, P < .05; III vs IVA, P < .001; IVA vs IVB, P < .05) in the HPV-negative cohort, whereas only stages IVAs and IVB ( P < .01) exhibited a significant difference in overall survival for HPV-positive patients. Conclusion The current AJCC staging system does not accurately distinguish risk of mortality for patients with HPV-positive disease. These data support the consideration of HPV status in estimating prognosis as well as clinical trial design and clinical decision making for patients with laryngeal squamous cell carcinoma.

Validation of the eighth edition AJCC staging system in early T1 to T2 oral squamous cell carcinoma

2018 ◽  
Vol 119 (4) ◽  
pp. 449-454 ◽  
Author(s):  
Samskruthi Murthy ◽  
Tsu-Hui Hubert Low ◽  
Narayana Subramaniam ◽  
Deepak Balasubramanian ◽  
Vidhyadharan Sivakumaran ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Staging System ◽  
Ajcc Staging System ◽  
Eighth Edition ◽  
Ajcc Staging

scholarly journals Nomogram for predicting cancer-specific survival of patients with buccal squamous cell carcinoma: a population-based study

2020 ◽  
Author(s):  
Wei-Ming Wang ◽  
xiuhong chu ◽  
sisi yang ◽  
ying wang ◽  
chuanyu hu
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Prognostic Value ◽  
Cox Regression ◽  
Staging System ◽  
Cancer Specific Survival ◽  
Ajcc Staging System ◽  
Ajcc Staging ◽  
Buccal Squamous Cell Carcinoma

Abstract Background The use of the traditional American Joint Committee on Cancer (AJCC) staging system alone has limitations in predicting the survival of buccal squamous cell carcinoma (BSCC) patients. We aimed to establish a comprehensive prognostic nomogram whose prognostic value compared with AJCC system. Methods Patients were obtained from the SEER (Surveillance, Epidemiology, and End Result) database. The Cox regression model was used to select variables using a backward stepwise selection method. Based on the predictive model for determining prognostic factors, a nomogram was developed to predict the cancer-specific survival rates of BSCC patients at 3, 5 and 8 years. We used several standard model validation methods to evaluate the performance of the survival model: concordance index (C-index), area under the time-dependent receiver operating characteristic curve (AUC), net reclassification improvement (NRI), calibration plots, decision curve analyses (DCAs), and integrated discrimination improvement (IDI). Results Multivariate analysis showed that age, AJCC stage, N stage, M stage, pathological grade, and surgical status were risk factors for survival. The c-index chart, the AUC chart, and the calibration chart show that the performance of the nomogram is better, and the NRI and IDI values show that the performance of the nomogram is better than that of the AJCC staging system. The 3-year, 5-year and 8-year DCA curves of nomogram show that it has more net benefit than traditional AJCC staging system, both in terms of training and validation queues. Conclusion We developed and validated the first BSCC prognosis nomogram, which has a better prognostic value than the separate AJCC staging system. Our BSCC prognosis nomogram is a valuable tool for explaining the risks of the next 3, 5 and 8 years in clinical practice.

scholarly journals Low level of interobserver concordance in assessing histological subtype and tumor grade in patients with penile cancer may impair patient care

2021 ◽  
Author(s):  
Luiza Dorofte ◽  
Diane Grélaud ◽  
Michelangelo Fiorentino ◽  
Francesca Giunchi ◽  
Costantino Ricci ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Penile Cancer ◽  
Histological Grade ◽  
Significant Risk ◽  
Tumor Grade ◽  
Patient Treatment ◽  
Histological Subtype ◽  
Penile Squamous Cell Carcinoma

AbstractDifferentiation between penile squamous cell carcinoma patients who can benefit from limited organ-sparing surgery and those at significant risk of lymph node metastasis is based on histopathological prognostic factors including histological grade and tumor histological subtype. We examined levels of interobserver and intraobserver agreement in assessment of histological subtype and grade in 207 patients with penile squamous cell carcinoma. The cases were assessed by seven pathologists from three hospitals located in Sweden and Italy. There was poor to moderate concordance in assessing both histological subtype and grade, with Fleiss kappas of 0.25 (range: 0.02–0.48) and 0.23 (range: 0.07–0.55), respectively. When choosing HPV-associated and non-HPV-associated subtypes, interobserver concordance ranged from poor to good, with a Fleiss kappa value of 0.36 (range: 0.02–0.79). A re-review of the slides by two of the pathologists showed very good intraobserver concordance in assessing histological grade and subtype, with Cohen’s kappa values of 0.94 and 0.91 for grade and 0.95 and 0.84 for subtype. Low interobserver concordance could lead to undertreatment and overtreatment of many patients with penile cancer, and brings into question the utility of tumor histological subtype and tumor grade in determining patient treatment in pT1 tumors.

Immunohistochemical Expression of TGF-β3 in Oral Squamous Cell Carcinoma

2019 ◽  
Vol 10 (01) ◽  
Author(s):  
Asmaa Ali Hussein
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Transforming Growth Factor ◽  
Tumor Grade ◽  
Tumor Stage ◽  
High Rate ◽  
Female Ratio ◽  
Positive Expression

Squamous cell carcinoma characterized by poor prognosis due to aggressive tumor growth and dissemination high rate of tumor cell . age ranged of patient case included in the study 40-62 years and mean age 55±99. The sex distribution male/female ratio 1:1. Male case 15 and female 15 of the present study The results of clinical forums showed in the current study was endophytic 10(33.3%) in the same time Exophytic were presented in 20 cases (76.7%). Regarding distribution of the tumors site, the preponderance of them 19 cases 73.3% were located alveolar mucosa, followed by in the tongue 11 cases(36.7%) Tumor stage was analyzed and recorded in Oral squamous cell carcinoma included cases, the preponderance of them were Stage II 11 cases 36.7% followed by stage III 10 cases 33.3% , 9 cases 30.0% were stage I. While Concerning tumor grade, majority of them 15 cases 50% had grade II moderately differentiated SCC, while 11 cases 36.7% had grade III poorly differentiated SCC and 4 cases 13.3% had grade I well differentiated SCC Positive TGF-β3 immunostaining was detected as cell with staining brown color, all tissues sections included show Positive expression based on IHC teqnique. Positive Transforming Growth Factor TGF-β3 Immuno staining was found in all case results and display that 4 samples with percentage 13.3% expressed strong positive 87.67 ± 1.45 expression , 11cases 36.7% showed 51.33 ±0.88 positive expression moderate at the same time 15 samples 50.0% showed positive weak expression.

Sign in / Sign up

Export Citation Format

Share Document