Biodegradable Hyaluronic Acid/N-Carboxyethyl Chitosan/Protein Ternary Complexes as Implantable Carriers for Controlled Protein Release

2005 ◽  
Vol 5 (12) ◽  
pp. 1226-1233 ◽  
Author(s):  
Hongliang Jiang ◽  
Yijuan Wang ◽  
Qian Huang ◽  
Yan Li ◽  
Chaonan Xu ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Ternary Complexes ◽  
Protein Release

scholarly journals How Poloxamer Addition in Hyaluronic-Acid-Decorated Biodegradable Microparticles Affects Polymer Degradation and Protein Release Kinetics

2021 ◽  
Vol 11 (16) ◽  
pp. 7567
Author(s):  
Teresa Silvestri ◽  
Barbara Immirzi ◽  
Giovanni Dal Poggetto ◽  
Paola Di Donato ◽  
Valentina Mollo ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Degradation Rate ◽  
Degradation Kinetics ◽  
Dynamic Balance ◽  
Release Kinetics ◽  
Slight Modification ◽  
Gel Permeation Chromatography ◽  
Protein Release ◽  
Polymeric Microparticles ◽  
Biodegradable Microparticles

Polymeric microparticles (MPs) designed for the intravitreal administration of therapeutic proteins result in a prolonged half-life in the vitreous and can delay or discourage the onset of adverse effects inevitably related to this route of administration. Hence, here we designed MPs composed of a polymeric blend based on poly(lactic-co-glycolic) acid and poloxamers, externally decorated with hyaluronic acid. The MPs are intended for intravitreal administration of bovine serum albumin. In detail, a systematic formulative study aiming to shed light on the complex relationship between protein release rate and MP degradation rate was carried out by means of calorimetric and gel permeation chromatography analyses. We found out that poloxamer addition caused a compact MP matrix, which led to a slight modification of the degradation kinetics and a reduction in the initial BSA initial release, which is of the utmost importance to ensure a relatively regular BSA release. It must also be underlined that for acid-labile molecules such as proteins, the poloxamer’s presence induced complex and hardly predictable effects on MP degradation/protein release, due to the dynamic balance between the time-evolving hydrophilicity of MPs and the influence of poloxamers themselves on the PLGA degradation rate.

Modulating Protein Release Profiles by Incorporating Hyaluronic Acid into PLGA Microparticles Via a Spray Dryer Equipped with a 3-Fluid Nozzle

2014 ◽  
Vol 31 (11) ◽  
pp. 2940-2951 ◽  
Author(s):  
Feng Wan ◽  
Morten Jonas Maltesen ◽  
Sune Klint Andersen ◽  
Simon Bjerregaard ◽  
Stefania G. Baldursdottir ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Protein Release ◽  
Spray Dryer ◽  
Plga Microparticles ◽  
Release Profiles

Calcium ion modulates protein release from chitosan-hyaluronic acid poly electrolyte gel

2015 ◽  
Vol 55 (9) ◽  
pp. 2089-2097 ◽  
Author(s):  
A. Shanti Krishna ◽  
C. Radhakumary ◽  
K. Sreenivasan
Keyword(s):  
Hyaluronic Acid ◽  
Calcium Ion ◽  
Protein Release

Physicochemical and in vitro evaluation of cationic liposome, hyaluronic acid and plasmid DNA as pseudo-ternary complexes for gene delivery

2015 ◽  
Vol 484 ◽  
pp. 262-270 ◽  
Author(s):  
Tiago A. Balbino ◽  
Gabriela S.C. Correa ◽  
Marianna T.P. Favaro ◽  
Marcelo A.S. Toledo ◽  
Adriano R. Azzoni ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Gene Delivery ◽  
Plasmid Dna ◽  
Cationic Liposome ◽  
Ternary Complexes ◽  
In Vitro Evaluation
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