PMPC Modified PAMAM Dendrimer Enhances Brain Tumor‐Targeted Drug Delivery

2021 ◽  
pp. 2000392
Author(s):  
Jiamin Ban ◽  
Sidi Li ◽  
Qi Zhan ◽  
Xuepin Li ◽  
Huike Xing ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Brain Tumor ◽  
Targeted Drug Delivery ◽  
Pamam Dendrimer ◽  
Targeted Drug

Mathematical modeling and optimal control problems in brain tumor targeted drug delivery strategies

2017 ◽  
Vol 10 (04) ◽  
pp. 1750056 ◽  
Author(s):  
Aziz Belmiloudi
Keyword(s):  
Drug Delivery ◽  
Optimal Control ◽  
Brain Tumor ◽  
Targeted Drug Delivery ◽  
Optimal Control Problems ◽  
Control Problems ◽  
Mathematical Framework ◽  
Normal Cells ◽  
Regularity Of Solution ◽  
Targeted Drug

In this paper, we present a mathematical model that describes tumor-normal cells interaction dynamics focusing on role of drugs in treatment of brain tumors. The goal is to predict distribution and necessary quantity of drugs delivered in drug-therapy by using optimal control framework. The model describes interactions of tumor and normal cells using a system of reactions–diffusion equations involving the drug concentration, tumor cells and normal tissues. The control estimates simultaneously blood perfusion rate, reabsorption rate of drug and drug dosage administered, which affect the effects of brain tumor chemotherapy. First, we develop mathematical framework which models the competition between tumor and normal cells under chemotherapy constraints. Then, existence, uniqueness and regularity of solution of state equations are proved as well as stability results. Afterwards, optimal control problems are formulated in order to minimize the drug delivery and tumor cell burden in different situations. We show existence and uniqueness of optimal solution, and we derive necessary conditions for optimality. Finally, to solve numerically optimal control and optimization problems, we propose and investigate an adjoint multiple-relaxation-time lattice Boltzmann method for a general nonlinear coupled anisotropic convection–diffusion system (which includes the developed model for brain tumor targeted drug delivery system).

scholarly journals Design, Synthesis, and Biological Evaluations of Asymmetric Bow-Tie PAMAM Dendrimer-Based Conjugates for Tumor-Targeted Drug Delivery

ACS Omega ◽  
2018 ◽  
Vol 3 (4) ◽  
pp. 3717-3736 ◽  
Author(s):  
Tao Wang ◽  
Yaozhong Zhang ◽  
Longfei Wei ◽  
Yuhan G. Teng ◽  
Tadashi Honda ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Pamam Dendrimer ◽  
Design Synthesis ◽  
Targeted Drug ◽  
Bow Tie

d-Retroenantiomer of Quorum-Sensing Peptide-Modified Polymeric Micelles for Brain Tumor-Targeted Drug Delivery

2017 ◽  
Vol 9 (31) ◽  
pp. 25672-25682 ◽  
Author(s):  
Danni Ran ◽  
Jiani Mao ◽  
Changyou Zhan ◽  
Cao Xie ◽  
Huitong Ruan ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Brain Tumor ◽  
Quorum Sensing ◽  
Targeted Drug Delivery ◽  
Polymeric Micelles ◽  
Targeted Drug

scholarly journals Overcoming blood‐brain barrier by targeted drug delivery to brain tumor vasculature with carbohydrate mimetic peptide in mouse glioma model (607.13)

2014 ◽  
Vol 28 (S1) ◽  
Author(s):  
Misa Suzuki‐Anekoji ◽  
Jiunn‐Chern Yeh ◽  
Motohiro Nonaka ◽  
Toshiaki Shibata ◽  
Jun Nakayama ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Brain Tumor ◽  
Blood Brain Barrier ◽  
Targeted Drug Delivery ◽  
Tumor Vasculature ◽  
Brain Barrier ◽  
Mimetic Peptide ◽  
Blood Brain ◽  
Targeted Drug ◽  
Mouse Glioma

Smart bomb AS1411 aptamer-functionalized/PAMAM dendrimer nanocarriers for targeted drug delivery in the treatment of gastric cancer

2016 ◽  
Vol 44 (1) ◽  
pp. 41-51 ◽  
Author(s):  
Amir Barzegar Behrooz ◽  
Fatemeh Nabavizadeh ◽  
Jamal Adiban ◽  
Mehdi Shafiee Ardestani ◽  
Rouhollah Vahabpour ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Pamam Dendrimer ◽  
Targeted Drug ◽  
As1411 Aptamer ◽  
Smart Bomb

scholarly journals Brain tumor-targeted drug delivery strategies

2014 ◽  
Vol 4 (3) ◽  
pp. 193-201 ◽  
Author(s):  
Xiaoli Wei ◽  
Xishan Chen ◽  
Man Ying ◽  
Weiyue Lu
Keyword(s):  
Drug Delivery ◽  
Brain Tumor ◽  
Targeted Drug Delivery ◽  
Delivery Strategies ◽  
Targeted Drug

scholarly journals Cellulose nanocrystals as a novel nanocarrier for targeted drug delivery to brain tumor cells

2011 ◽  
Vol 25 (S1) ◽  
Author(s):  
Hyung Joon Cho ◽  
Somin Lee ◽  
Shuping Dong ◽  
Maren Roman ◽  
Yong Woo Lee
Keyword(s):  
Drug Delivery ◽  
Brain Tumor ◽  
Tumor Cells ◽  
Cellulose Nanocrystals ◽  
Targeted Drug Delivery ◽  
Brain Tumor Cells ◽  
Targeted Drug
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