scholarly journals Design, Synthesis, and Biological Evaluations of Asymmetric Bow-Tie PAMAM Dendrimer-Based Conjugates for Tumor-Targeted Drug Delivery

ACS Omega ◽  
2018 ◽  
Vol 3 (4) ◽  
pp. 3717-3736 ◽  
Author(s):  
Tao Wang ◽  
Yaozhong Zhang ◽  
Longfei Wei ◽  
Yuhan G. Teng ◽  
Tadashi Honda ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Pamam Dendrimer ◽  
Design Synthesis ◽  
Targeted Drug ◽  
Bow Tie

scholarly journals Redox-Sensitive Linear and Cross-Linked Cystamine-Based Polymers for Colon-Targeted Drug Delivery: Design, Synthesis, and Characterisation

Pharmaceutics ◽  
2020 ◽  
Vol 12 (5) ◽  
pp. 461
Author(s):  
Yoke Mooi Ng ◽  
Siti Nur Aishah Mat Yusuf ◽  
Hock Ing Chiu ◽  
Vuanghao Lim
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Design Synthesis ◽  
Disulfide Linkage ◽  
X Ray ◽  
Physical Conditions ◽  
Targeted Drug ◽  
Trimesoyl Chloride ◽  
Acid Reduction ◽  
Scanning Electron

Cystamine-based polymers may help to achieve controlled and targeted drug delivery to the colon due to their susceptibility to breakage of the disulfide linkage in the low redox potential environment of the colon. In this study, two linear cystamine-based polymers with similar repeating units (LP1 and LP2) and a cross-linked cystamine-based polymer (BP) were synthesised and their kinetics and the various physical conditions underlying cystamine-based polymerisation were evaluated. In brief, N1,N6-bis(2-(tritylthio)ethyl)adipamide (2) was synthesised from the reaction of triphenylmethanol and cysteamine. Next, the trityl group of 2 was removed with trifluoroacetic acid and triethylsilane before proceeding to oxidative polymerisation of the end product, N1,N6-bis(2-mercaptoethyl)adipamide (3) to LP1. The Schotten-Bauman reaction was applied to synthesise LP2 and BP from the reaction of cystamine with adipoyl chloride or trimesoyl chloride. Scanning electron microscopy, energy-dispersive X-ray spectroscopy, and mapping showed that oxygen, nitrogen, sulfur, and carbon were homogenously distributed in the polymers, with LP2 and BP having less porous morphologies compared to LP1. Results of zinc-acetic acid reduction showed that all polymers began to reduce after 15 min. Moreover, all synthesised polymers resisted stomach and small intestine conditions and only degraded in the presence of bacteria in the colon environment. Thus, these polymers have great potential for drug delivery applications. LP2 and BP, which were synthesised using the Schotten-Bauman reaction, were more promising than LP1 for colon-targeted drug delivery.

Smart bomb AS1411 aptamer-functionalized/PAMAM dendrimer nanocarriers for targeted drug delivery in the treatment of gastric cancer

2016 ◽  
Vol 44 (1) ◽  
pp. 41-51 ◽  
Author(s):  
Amir Barzegar Behrooz ◽  
Fatemeh Nabavizadeh ◽  
Jamal Adiban ◽  
Mehdi Shafiee Ardestani ◽  
Rouhollah Vahabpour ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Pamam Dendrimer ◽  
Targeted Drug ◽  
As1411 Aptamer ◽  
Smart Bomb

Design, synthesis and evaluation of biotin decorated inulin-based polymeric micelles as long-circulating nanocarriers for targeted drug delivery

2017 ◽  
Vol 13 (3) ◽  
pp. 1245-1254 ◽  
Author(s):  
Delia Mandracchia ◽  
Antonio Rosato ◽  
Adriana Trapani ◽  
Theodora Chlapanidas ◽  
Isabella Monia Montagner ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Polymeric Micelles ◽  
Design Synthesis ◽  
Targeted Drug

PMPC Modified PAMAM Dendrimer Enhances Brain Tumor‐Targeted Drug Delivery

2021 ◽  
pp. 2000392
Author(s):  
Jiamin Ban ◽  
Sidi Li ◽  
Qi Zhan ◽  
Xuepin Li ◽  
Huike Xing ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Brain Tumor ◽  
Targeted Drug Delivery ◽  
Pamam Dendrimer ◽  
Targeted Drug

Design, Synthesis, Selective Recognition Properties and Targeted Drug Delivery Application

2014 ◽  
pp. 1-75 ◽  
Author(s):  
Jarmila Králová ◽  
Zdenĕk Kejík ◽  
Tomáš Bříza ◽  
Robert Kaplánek ◽  
Kamil Záruba ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Selective Recognition ◽  
Design Synthesis ◽  
Drug Delivery Application ◽  
Targeted Drug

scholarly journals Synthesis of poly (amidoamine) (PAMAM) dendrimer-based chitosan for targeted drug delivery and cell therapy

2018 ◽  
Vol 5 (4) ◽  
pp. 6-13 ◽  
Author(s):  
Leila Sofi Maryo Sofi Maryo ◽  
Nahid Haghnazari ◽  
Fatemeh Keshavarzi ◽  
Hassan Zhaleh ◽  
Farzad Seidi ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cell Therapy ◽  
Targeted Drug Delivery ◽  
Pamam Dendrimer ◽  
Targeted Drug

scholarly journals Recent Advances in Magnetic Upconversion Nanocomposites for Bioapplications

2019 ◽  
Vol 25 (17) ◽  
pp. 2007-2015 ◽  
Author(s):  
Yadan Ding ◽  
Xia Hong ◽  
Yichun Liu ◽  
Hong Zhang
Keyword(s):  
Drug Delivery ◽  
Luminescent Property ◽  
Targeted Drug Delivery ◽  
Surface Engineering ◽  
State Of The Art ◽  
Structure Design ◽  
Synthesis Methods ◽  
Design Synthesis ◽  
Targeted Drug ◽  
Guided Therapy

The combination of magnetism and upconversion luminescent property into one single nanostructure is fascinating for biological fields, such as multimodal bioimaging, targeted drug delivery, and imaging-guided therapy. In this review, we will provide the state-of-the-art advances on magnetic upconversion nanocomposites towards their bioapplications. Their structure design, synthesis methods, surface engineering and applications in bioimaging, drug delivery, therapy as well as biodetection will be covered.

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