Controlled Drug Release from Weakly Crosslinked Molecularly Imprinted Networks: The Benefit of Living Radical Polymerization

2013 ◽  
Vol 214 (20) ◽  
pp. 2355-2366 ◽  
Author(s):  
Vishal D. Salian ◽  
Mark E. Byrne
Keyword(s):  
Drug Release ◽  
Radical Polymerization ◽  
Controlled Drug Release ◽  
Living Radical Polymerization ◽  
Molecularly Imprinted

Photonic Crystal-Embedded Molecularly Imprinted Contact Lenses for Controlled Drug Release

2021 ◽  
Author(s):  
Zhaoran Chu ◽  
Chao Xue ◽  
Kan Shao ◽  
Lanlan Xiang ◽  
Xueling Zhao ◽  
...  
Keyword(s):  
Photonic Crystal ◽  
Drug Release ◽  
Contact Lenses ◽  
Controlled Drug Release ◽  
Molecularly Imprinted

Preparation of a Thermo-Sensitive Poly(N-Acryloyl Alanine Methyl Ester) for Controlled Drug Release

2011 ◽  
Vol 306-307 ◽  
pp. 675-678 ◽  
Author(s):  
Kui Lin Deng ◽  
Hai Bin Zhong ◽  
Yu’e Shi ◽  
Jian Zuo ◽  
Chun Yan Jiang ◽  
...  
Keyword(s):  
Methyl Ester ◽  
Drug Release ◽  
Aqueous Solutions ◽  
Radical Polymerization ◽  
Pure Water ◽  
Controlled Drug Release ◽  
Drug Release Study ◽  
H Nmr ◽  
Release Study ◽  
Thermo Sensitivity

A novel thermo-sensitive poly(N-acryloyl alanine methyl ester) (PAAME) was synthesized by radical polymerization. The structures of the corresponding monomer and polymer have been confirmed by1H NMR and FTIR measurements. The thermo-sensitivity of PAAME was investigated by measuring their lower critical solution temperatures (LCST) in pure water and at different pH solution. The results indicated that PAAME exhibited a reversible thermo-sensibility in its aqueous solutions at 17.7 °C. The drug release study showed that 72% caffeine was released from hydrogel at 37 °C after 6 hours, while more than 94% caffeine was gradually diffused into the medium at 18 °C.

scholarly journals Reduction-Responsive Molecularly Imprinted Poly(2-isopropenyl-2-oxazoline) for Controlled Release of Anticancer Agents

Pharmaceutics ◽  
2020 ◽  
Vol 12 (6) ◽  
pp. 506 ◽  
Author(s):  
Michał Cegłowski ◽  
Valentin Victor Jerca ◽  
Florica Adriana Jerca ◽  
Richard Hoogenboom
Keyword(s):  
Controlled Release ◽  
Drug Release ◽  
Anticancer Agents ◽  
Release Kinetics ◽  
Controlled Drug Release ◽  
Release Mechanism ◽  
Molecularly Imprinted ◽  
Responsive Materials ◽  
Future Work ◽  
Specific Trigger

Trigger-responsive materials are capable of controlled drug release in the presence of a specific trigger. Reduction induced drug release is especially interesting as the reductive stress is higher inside cells than in the bloodstream, providing a conceptual controlled release mechanism after cellular uptake. In this work, we report the synthesis of 5-fluorouracil (5-FU) molecularly imprinted polymers (MIPs) based on poly(2-isopropenyl-2-oxazoline) (PiPOx) using 3,3′-dithiodipropionic acid (DTDPA) as a reduction-responsive functional cross-linker. The disulfide bond of DTDPA can be cleaved by the addition of tris(2-carboxyethyl)phosphine (TCEP), leading to a reduction-induced 5-FU release. Adsorption isotherms and kinetics for 5-FU indicate that the adsorption kinetics process for imprinted and non-imprinted adsorbents follows two different kinetic models, thus suggesting that different mechanisms are responsible for adsorption. The release kinetics revealed that the addition of TCEP significantly influenced the release of 5-FU from PiPOx-MIP, whereas for non-imprinted PiPOx, no statistically relevant differences were observed. This work provides a conceptual basis for reduction-induced 5-FU release from molecularly imprinted PiPOx, which in future work may be further developed into MIP nanoparticles for the controlled release of therapeutic agents.

Preparation of molecularly imprinted polymers using nitroxide-mediated living radical polymerization

2006 ◽  
Vol 22 (3) ◽  
pp. 349-354 ◽  
Author(s):  
Somchai Boonpangrak ◽  
Michael J. Whitcombe ◽  
Virapong Prachayasittikul ◽  
Klaus Mosbach ◽  
Lei Ye
Keyword(s):  
Radical Polymerization ◽  
Molecularly Imprinted Polymers ◽  
Living Radical Polymerization ◽  
Molecularly Imprinted ◽  
Imprinted Polymers

Molecularly Imprinted Polymers and Controlled/Living Radical Polymerization

2009 ◽  
Vol 62 (8) ◽  
pp. 751 ◽  
Author(s):  
Marc Bompart ◽  
Karsten Haupt
Keyword(s):  
Radical Polymerization ◽  
Molecularly Imprinted Polymers ◽  
Hormone Receptors ◽  
Great Majority ◽  
Living Radical Polymerization ◽  
Controlled Polymerization ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
Target Molecules ◽  
Controlled Living Radical Polymerization

Molecularly imprinted polymers (MIPs) are tailor-made biomimetic receptors that are obtained by polymerization in the presence of molecular templates. They contain binding sites for target molecules with affinities and specificities on a par with those of natural receptors such as antibodies, hormone receptors, or enzymes. A great majority of the literature in the field describes materials based on polymers obtained by free radical polymerization. In order to solve general problems associated with MIPs, in particular their heterogeneity in terms of inner morphology and distribution of binding site affinities, it has been suggested to use modern methods of controlled/living radical polymerization for their synthesis. This also facilitates their generation in the form of nanomaterials, nanocomposites, and thin films, a strong recent trend in the field. The present paper reviews recent advances in the molecular imprinting area, with special emphasis on the use of controlled polymerization methods, their benefits, and current limitations.

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