Physicochemical Properties of Injectable Hyaluronic Acid: Skin Quality Boosters

The aging process involves physical, social, and psychological changes. With the increase in life expectancy, the demand for aesthetic treatments is increasingly noticed in the search for harmonious and slower aging. This article reports a clinical case of a 42-year-old female patent complaining of onset of skin ﬂaccidity and fall of the labial commissure, in additon to a tired and saddened appearance - known as “Sad Look”. A combination of common procedures in Orofacial Harmonization such as application of botulinium toxin, filling with plasma gel and filling with hyaluronic acid were used as a rejuvenation objective. The main results obtained were the reestablishment of the balance of muscular strength, the stimulation of collagen production and consequently the improvement of skin quality and lessen ﬂaccidity, as well as the the return of volume and lost facial contours.

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Relaxation and diffusion of water protons in BDDE cross-linked hyaluronic acid hydrogels investigated by NMR spectroscopy—Comparison with physicochemical properties

Carbohydrate Polymers ◽

10.1016/j.carbpol.2020.116768 ◽

2020 ◽

Vol 248 ◽

pp. 116768

Author(s):

Frida J. Wende ◽

Yan Xue ◽

Gustav Nestor ◽

Åke Öhrlund ◽

Corine Sandström

Keyword(s):

Hyaluronic Acid ◽

Nmr Spectroscopy ◽

Physicochemical Properties ◽

And Diffusion

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Polysaccharides in Ocular Drug Delivery

Pharmaceutics ◽

10.3390/pharmaceutics12010022 ◽

2019 ◽

Vol 12 (1) ◽

pp. 22 ◽

Cited By ~ 11

Author(s):

Natallia Dubashynskaya ◽

Daria Poshina ◽

Sergei Raik ◽

Arto Urtti ◽

Yury A. Skorik

Keyword(s):

Drug Delivery ◽

Hyaluronic Acid ◽

Physicochemical Properties ◽

Alginic Acid ◽

Drug Carriers ◽

Ocular Drug Delivery ◽

Pharmacological Effects ◽

Drug Formulations ◽

Ophthalmic Drugs ◽

Polysaccharide Derivatives

Polysaccharides, such as cellulose, hyaluronic acid, alginic acid, and chitosan, as well as polysaccharide derivatives, have been successfully used to augment drug delivery in the treatment of ocular pathologies. The properties of polysaccharides can be extensively modified to optimize ocular drug formulations and to obtain biocompatible and biodegradable drugs with improved bioavailability and tailored pharmacological effects. This review discusses the available polysaccharide choices for overcoming the difficulties associated with ocular drug delivery, and it explores the reasons for the dependence between the physicochemical properties of polysaccharide-based drug carriers and their efficiency in different formulations and applications. Polysaccharides will continue to be of great interest to researchers endeavoring to develop ophthalmic drugs with improved effectiveness and safety.

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