Evaluation of safety and efficacy of booster injections of hyaluronic acid in improving the facial skin quality

2020 ◽  
Vol 19 (9) ◽  
pp. 2267-2272 ◽  
Author(s):  
Azin Ayatollahi ◽  
Alireza Firooz ◽  
Aniseh Samadi
Keyword(s):  
Hyaluronic Acid ◽  
Facial Skin ◽  
Safety And Efficacy ◽  
Skin Quality

scholarly journals Physicochemical Properties of Injectable Hyaluronic Acid: Skin Quality Boosters

2021 ◽  
pp. 2100134
Author(s):  
Linda Kleine‐Börger ◽  
Alexander Kalies ◽  
Robert SA Meyer ◽  
Martina Kerscher
Keyword(s):  
Hyaluronic Acid ◽  
Physicochemical Properties ◽  
Skin Quality

scholarly journals Investigate the improvement of facial skin texture with the VISIA system after total thyroidectomy

BMC Surgery ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Spencer C. H. Kuo ◽  
Faye Huang ◽  
Shun-Yu Chi ◽  
Hui-Ping Lin ◽  
Peng-Chen Chien ◽  
...  
Keyword(s):  
Total Thyroidectomy ◽  
Surgical Removal ◽  
Facial Skin ◽  
Skin Texture ◽  
Sphericity Test ◽  
Preoperative Stage ◽  
Before And After ◽  
A Prospective Study ◽  
Skin Quality ◽  
Tsh Levels

Abstract Background During clinical practice we have noticed that some patients with hyperthyroidism have finer skin with less wrinkles, pores, and spots after thyroidectomy, and the improvement can be observed within a few weeks after the operation. However, there is no evidence or study in the literature to proof this finding. Aim and objective This study was designed to evaluate and quantify the skin characters of patients with hyperthyroidism before and after thyroidectomy. Material and methods This is a prospective study to include patients with hyperthyroidism who received total thyroidectomy between March 1st, 2018 and February 28th, 2019. The patients received blood test for T4 and TSH analysis and VISIA measurements for skin texture quantification, at the preoperative stage, three, and six months postoperatively. A total of 8 patients were included. Repeated measurement was used to determine the lab data and VISIA measurement changes before and after the operation. Mauchly’s sphericity test was performed to determine whether the violation of sphericity occurs, and the Greenhouse–Geisser correction was used when the violation of sphericity occurs. Results All the patients were female and generally healthy without systemic medical disease except the hyperthyroidism. The T4 and TSH levels were not significantly different before and after the thyroidectomy. In terms of the skin character measurements, the wrinkles, texture, pores, UV spots, and brown spots were not improved after thyroidectomy. A trend of improvement in spots, red area, and porphyrin was noted, although not statistically significant. Conclusions Surgical removal of the thyroid gland in patients with hyperthyroidism does not improve the skin quality and texture in examinations via the VISIA system.

scholarly journals “Nanomaterials of curcumin-hyaluronic acid”: their various methods of formulations, clinical and therapeutic applications, present gap, and future directions

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Tanzeel Rehman Charan ◽  
Muhammad Aqeel Bhutto ◽  
Mihr Ali Bhutto ◽  
Azhar Ali Tunio ◽  
Ghulam Murtaza Khuhro ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Hyaluronic Acid ◽  
Future Research ◽  
Main Body ◽  
Future Directions ◽  
Research Directions ◽  
Safety And Efficacy ◽  
Therapeutic Applications ◽  
Future Research Directions ◽  
Neural Disorders

Abstract Background Nanomaterials of curcumin with hyaluronic acid have gained a lot of attention for potential therapeutic applications of curcumin and hyaluronic acid with or without other additional drugs. Overall studies of curcumin and hyaluronic acid show that nanomaterials of curcumin with hyaluronic acid accelerate the efficacy of curcumin in the treatment of various disorders like arthritis, cancer, hepatic fibrosis, neural disorders, wound healing, and skin regeneration, it is largely due to the combined effect of hyaluronic acid and curcumin. However, due to limited clinical trials and experiments on humans and animals, there is a substantial gap in research for the safety and efficacy of nanomaterials of curcumin-hyaluronic acid in the treatment of curcumin and hyaluronic acid targeted diseases and disorders. Main body of the abstract In this current review, we have first described various reported synthetic nanomaterials of curcumin-hyaluronic acid, then in the next section, we have described various fields, disorders, and diseases where these are being applied and in the final section of this review, we discussed the research gap, and future research directions needed to propose the fabricated nanocurcumin-hyaluronic acid biomaterials. Short conclusion There are substantial gaps in research for the safety and efficacy of nanomaterials of curcumin with hyaluronic acid due to limited available data of clinical trials and experiments of nanocurcumin-hyaluronic acid biomaterials on humans and animals. So, it entirely requires serious and committed efforts through the well-organized system of practical and clinical trials which provide results, data, and detections that lead to the formulation of the best drug from curcumin with hyaluronic acid for the treatment of curcumin and hyaluronic acid targeted diseases and disorders.

Safety and efficacy of sirolimus gel therapy for patients with TSC involving facial skin lesions in a long-term clinical trial

2019 ◽  
Author(s):  
Mari Wataya-Kaneda ◽  
H Nagai ◽  
Y Ohno ◽  
H Yokozeki ◽  
Yasuyuki Fujita ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Skin Lesions ◽  
Facial Skin ◽  
Safety And Efficacy

scholarly journals Evaluating the Safety and Efficacy of a Highly Viscous 33-mg/mL Hyaluronic Acid Volumizing Filler in the Treatment of Facial Wrinkles: An Open-Labeled, Clinical Trials

2019 ◽  
Vol 8 ◽  
pp. e1148
Author(s):  
Elnaz Razavian ◽  
Setareh Tehrani
Keyword(s):  
Hyaluronic Acid ◽  
High Volume ◽  
Soft Tissue Augmentation ◽  
Nodule Formation ◽  
Safety And Efficacy ◽  
Significant Correction ◽  
Clinically Significant ◽  
One Year ◽  
First Time

Background: The 33-mg/mL hyaluronic acid (HA) formulation is a highly concentrated, cross-linked, cohesive, smooth, and completely reversible volumizing filler approved by Conformité Européene. For the first time, we aimed to evaluate the long-term efficacy and safety of the 33-mg/mL HA filler for soft tissue augmentation in the treatment of facial wrinkles. Materials and Methods: After optimal wrinkle correction was achieved in the patients undergoing treatment by injecting the 33-mg/mL HA filler at the injection site plus one touch-up at a 2-week interval, the safety and efficacy of the filler were assessed on the 5-point Facial Volume Loss Scale through the 1-year study period. Patients were evaluated daily for 14 days and after 6 and 12 months post-treatment. Results: A total of 86 subjects were treated. The mean wrinkle scores of the patients were 3.95+0.79 (range of 3-5) before treatment, 2.3+0.94 (range 1-5) six months after treatment, and 2.93+1.29 (range of 1-5) one year after treatment. Clinically significant mean wrinkle correction (P=0.001) was still evident at>12 months of treatment through 33-mg/mL HA formulation. A clinically significant correction at>12 months after treatment was maintained by 79% of patients. Nodule formation and swelling were more frequent when the 33-mg/mL HA filler was used compared with the use of less concentrated HA fillers. One patient developed angioedema-like swelling and induration last few months. Conclusion: The 33-mg/mL HA filler can provide long-term correction lasting for one year or more. Adverse effects, especially swelling and nodule formation were more common in this filler compared with less concentrated HA fillers. The side effects were correlated with the volume of the injected filler. We recommend using this concentration with low volume or combining high volume with lower concentration. [GMJ.2019;8:e1148]

Treatment of Stress Velopharyngeal Incompetence With Injection of Hyaluronic Acid

2017 ◽  
Vol 55 (4) ◽  
pp. 615-618 ◽  
Author(s):  
Steven Koprowski ◽  
Michael J. VanLue ◽  
Michael E. McCormick
Keyword(s):  
Hyaluronic Acid ◽  
Posterior Pharyngeal Wall ◽  
Clinical Entity ◽  
Multidisciplinary Management ◽  
Pharyngeal Wall ◽  
Safety And Efficacy ◽  
Velopharyngeal Incompetence ◽  
Acid Compound

Stress velopharyngeal incompetence (VPI) is a challenging clinical entity that can be managed by a variety of surgical and nonsurgical approaches. We describe the case of a clarinetist who presented with nasal air escape while playing. She had successful improvement in her symptoms after targeted injection of a hyaluronic acid compound to her posterior pharyngeal wall. Our objective is to describe the safety and efficacy of this technique, to emphasize the multidisciplinary management of patients with stress VPI, and to review the importance of both nasopharyngoscopy and videofluoroscopy in their evaluation.

Safety and efficacy of hyaluronic acid for the correction of nasolabial folds: A meta-analysis

2013 ◽  
Vol 23 (5) ◽  
pp. 592-599 ◽  
Author(s):  
Xiaolu Huang ◽  
Yimin Liang ◽  
Qingfeng Li
Keyword(s):  
Hyaluronic Acid ◽  
Meta Analysis ◽  
Safety And Efficacy ◽  
Nasolabial Folds
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