scholarly journals Multiple mechanisms are involved in 6-gingerol-induced cell growth arrest and apoptosis in human colorectal cancer cells

2008 ◽  
Vol 47 (3) ◽  
pp. 197-208 ◽  
Author(s):  
Seong-Ho Lee ◽  
Maria Cekanova ◽  
Seung Joon Baek
Keyword(s):  
Colorectal Cancer ◽  
Cell Growth ◽  
Cancer Cells ◽  
Growth Arrest ◽  
Human Colorectal Cancer ◽  
Cell Growth Arrest ◽  
Colorectal Cancer Cells ◽  
Human Colorectal Cancer Cells

scholarly journals Inhibitory effect of maple syrup on the cell growth and invasion of human colorectal cancer cells

2015 ◽  
Vol 33 (4) ◽  
pp. 1579-1584 ◽  
Author(s):  
TETSUSHI YAMAMOTO ◽  
KENTARO UEMURA ◽  
KAHO MORIYAMA ◽  
KUNIKO MITAMURA ◽  
ATSUSHI TAGA
Keyword(s):  
Colorectal Cancer ◽  
Cell Growth ◽  
Cancer Cells ◽  
Inhibitory Effect ◽  
Human Colorectal Cancer ◽  
Maple Syrup ◽  
Colorectal Cancer Cells ◽  
Human Colorectal Cancer Cells

Induction of cell growth arrest by atmospheric non-thermal plasma in colorectal cancer cells

2010 ◽  
Vol 150 (4) ◽  
pp. 530-538 ◽  
Author(s):  
Chul-Ho Kim ◽  
Jae Hoon Bahn ◽  
Seong-Ho Lee ◽  
Gye-Yeop Kim ◽  
Seung-Ik Jun ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cell Growth ◽  
Cancer Cells ◽  
Thermal Plasma ◽  
Growth Arrest ◽  
Cell Growth Arrest ◽  
Colorectal Cancer Cells ◽  
Non Thermal Plasma

scholarly journals Overexpression of 15-Lipoxygenase-1 Induces Growth Arrest through Phosphorylation of p53 in Human Colorectal Cancer Cells

2005 ◽  
Vol 3 (9) ◽  
pp. 511-517 ◽  
Author(s):  
Jong-Sik Kim ◽  
Seung Joon Baek ◽  
Frank G. Bottone ◽  
Tina Sali ◽  
Thomas E. Eling
Keyword(s):  
Colorectal Cancer ◽  
Cancer Cells ◽  
Growth Arrest ◽  
Human Colorectal Cancer ◽  
Colorectal Cancer Cells ◽  
Human Colorectal Cancer Cells

scholarly journals Knockdown of SLC39A7 inhibits cell growth and induces apoptosis in human colorectal cancer cells

2017 ◽  
Vol 49 (10) ◽  
pp. 926-934 ◽  
Author(s):  
Nengquan Sheng ◽  
Li Yan ◽  
Weiqiang You ◽  
Gewen Tan ◽  
Jianfeng Gong ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cell Growth ◽  
Cancer Cells ◽  
Human Colorectal Cancer ◽  
Colorectal Cancer Cells ◽  
Human Colorectal Cancer Cells

scholarly journals Upregulation of Polyamine Transport in Human Colorectal Cancer Cells

Biomolecules ◽  
2020 ◽  
Vol 10 (4) ◽  
pp. 499 ◽  
Author(s):  
Misael Corral ◽  
Heather M. Wallace
Keyword(s):  
Colorectal Cancer ◽  
Cell Growth ◽  
Cancer Cells ◽  
Cell Lines ◽  
Cancer Cell ◽  
Human Colorectal Cancer ◽  
Polyamine Transport ◽  
Colorectal Cancer Cells ◽  
Polyamine Content ◽  
Human Colorectal Cancer Cells

Polyamines are essential growth factors that have a positive role in cancer cell growth. Their metabolic pathway and the diverse enzymes involved have been studied in depth in multiple organisms and cells. Polyamine transport also contributes to the intracellular polyamine content but this is less well-studied in mammalian cells. As the polyamine transporters could provide a means of selective drug delivery to cancer cells, a greater understanding of polyamine transport and its regulation is needed. In this study, transport of polyamines and polyamine content was measured and the effect of modulating each was determined in human colorectal cancer cells. The results provide evidence that upregulation of polyamine transport depends on polyamine depletion and on the rate of cell growth. Polyamine transport occurred in all colorectal cancer cell lines tested but to varying extents. The cell lines with the lowest basal uptake showed the greatest increase in response to polyamine depletion. Kinetic parameters for putrescine and spermidine suggest the existence of two separate transporters. Transport was shown to be a saturable but non-polarised process that can be regulated both positively and negatively. Using the polyamine transporter to deliver anticancer drugs more selectively is now a reality, and the ability to manipulate the polyamine transport process increases the possibility of using these transporters therapeutically.

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