Cerebrospinal fluid GABA and homocarnosine concentrations in patients with Friedreich's ataxia, Parkinson's disease, and Huntington's chorea

1987 ◽  
Vol 2 (2) ◽  
pp. 117-123 ◽  
Author(s):  
A. M. Bonnet ◽  
G. Tell ◽  
P. J. Schechter ◽  
J. Grove ◽  
M. H. Saint-Hilaire ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cerebrospinal Fluid ◽  
Friedreich’S Ataxia ◽  
Friedreich's Ataxia ◽  
Huntington's Chorea

scholarly journals Erythrocyte Protoporphyrin Levels in Patients with Friedreich's and other Ataxias

1979 ◽  
Vol 6 (2) ◽  
pp. 227-232 ◽  
Author(s):  
R.O. Morgan ◽  
G. Naglie ◽  
D.F. Horrobin ◽  
A. Barbeau
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Duchenne Muscular Dystrophy ◽  
Muscular Dystrophy ◽  
Friedreich’S Ataxia ◽  
Friedreich's Ataxia ◽  
Normal Range ◽  
Free Erythrocyte Protoporphyrin ◽  
Erythrocyte Protoporphyrin ◽  
The Individual

SummaryOf 13 patients with Fried-reich's ataxia (Type la) and 17 with type Ila recessive ataxias, all were found to have levels of “free erythrocyte protoporphyrin “ (FEP) above the normal range. The rise in FEP in Friedreich's ataxia correlated well with the age of the individual and thus appears to be related to the course of the disease. Subjects with olivo-ponto-cerebel-lar atrophy, Charlevoix syndrome, Duchenne muscular dystrophy, and Parkinson's disease were also found to have significantly elevated FEP, although the distribution overlapped with the normal range.The finding of elevated FEP may indicate a relative heme deficiency in ataxia due to inhibition offerrochelatase leading to a state of ineffective, persistent erythropoiesis. The possibility of a prosta-glandin abnormality being related to this defect and to the pathogenesis of ataxia is considered.

scholarly journals Longitudinal Analysis of Multiple Neurotransmitter Metabolites in Cerebrospinal Fluid in Early Parkinson's Disease

2021 ◽  
Author(s):  
Thomas Kremer ◽  
Kirsten I. Taylor ◽  
Juliane Siebourg‐Polster ◽  
Thomas Gerken ◽  
Andreas Staempfli ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cerebrospinal Fluid ◽  
Longitudinal Analysis ◽  
Early Parkinson’S Disease ◽  
Neurotransmitter Metabolites

Decoupling of Global Brain Activity and Cerebrospinal Fluid Flow in Parkinson's Disease Cognitive Decline

2021 ◽  
Author(s):  
Feng Han ◽  
Gregory L. Brown ◽  
Yalin Zhu ◽  
Aaron E. Belkin‐Rosen ◽  
Mechelle M. Lewis ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cerebrospinal Fluid ◽  
Fluid Flow ◽  
Cognitive Decline ◽  
Brain Activity ◽  
Cerebrospinal Fluid Flow ◽  
Global Brain

Changes in endolysosomal enzyme activities in cerebrospinal fluid of patients with Parkinson's disease

2013 ◽  
Vol 28 (6) ◽  
pp. 747-754 ◽  
Author(s):  
Karin D. van Dijk ◽  
Emanuele Persichetti ◽  
Davide Chiasserini ◽  
Paolo Eusebi ◽  
Tommaso Beccari ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cerebrospinal Fluid ◽  
Enzyme Activities
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