The Fusarium toxin enniatin B exerts no genotoxic activity, but pronounced cytotoxicity in vitro

2009 ◽  
Vol 53 (4) ◽  
pp. 423-430 ◽  
Author(s):  
Claudia Behm ◽  
Gisela H. Degen ◽  
Wolfram Föllmann
2006 ◽  
Vol 20 (5) ◽  
pp. 703-711 ◽  
Author(s):  
K. Seeling ◽  
J. Boguhn ◽  
E. Strobel ◽  
S. Dänicke ◽  
H. Valenta ◽  
...  

2014 ◽  
Vol 229 ◽  
pp. S157
Author(s):  
Laura Coutinho ◽  
José Miguel P. Ferreira de Oliveira ◽  
Helena Oliveira ◽  
Conceição Santos

Immunobiology ◽  
2007 ◽  
Vol 212 (8) ◽  
pp. 655-666 ◽  
Author(s):  
D BIMCZOK ◽  
S DOLL ◽  
H RAU ◽  
T GOYARTS ◽  
N WUNDRACK ◽  
...  

2013 ◽  
Vol 59 (1) ◽  
pp. 107-114 ◽  
Author(s):  
A.K. Grekhova ◽  
L.B. Gorbacheva ◽  
N.A. Ivanova ◽  
I.A. Efimenko ◽  
A.N. Osipov

A comparative study on the genotoxic activity of cisplatin versus morfozol, the first representative of a new class of cation-anion complexes of palladium [AH] [PdCl ] (where A-methylmorpholine) has been performed using human lymphocytes in vitro. The results of the DNA-DNA cross-linking activity investigations showed that both compounds studied exhibited biphasic dose-effect relationship: a linear decrease in the DNA percent in the comet tail and the region of the "plateau". However, in the "plateau" region, morfozol reduced the DNA percent in the comet tail up to 6 times while cisplatin caused a 2-fold decrease only. Morfozol, like cisplatin, inducing DNA-protein cross-linking and generating reactive oxygen species, was more effective than cisplatin.


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