scholarly journals Preferences of psychiatric practitioners for core symptoms of major depressive disorder: a hidden conjoint analysis

2016 ◽  
Vol 26 (1) ◽  
pp. e1528 ◽  
Author(s):  
Matthias W. Riepe ◽  
Peter Gritzmann ◽  
Andreas Brieden
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Conjoint Analysis ◽  
Major Depressive ◽  
Core Symptoms

scholarly journals Core symptoms of major depressive disorder: relevance to diagnosis and treatment

2008 ◽  
Vol 10 (3) ◽  
pp. 271-277 ◽  
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Sleep Disturbance ◽  
Major Depressive Episode ◽  
Rating Scale ◽  
Symptom Clusters ◽  
Major Depressive ◽  
Associated Symptoms ◽  
Core Symptoms ◽  
Core Features

The construct of major depressive disorder makes no etiological assumptions about populations with diverse symptom clusters. "Depressed mood" and "loss of interest or pleasure in nearly all activities" are core features of major depressive episode, though a strong case can be made to pay increasing attention to symptoms of fatigue, sleep disturbance, anxiety, and neurocognitive and sexual dysfunction in the diagnosis and evaluation of treatment outcome. Mood, guilt, work, and interest, as well as psychic anxiety, are consistently identified across validated subscales of the Hamilton Depression Rating Scale as prevalent and sensitive to change with existing treatments. A major limitation of these antidepressant therapies is their narrow spectrum of action. While the core "mood and interest" symptoms have been the main focus of attention, the associated symptoms listed above are often unaffected or exacerbated by current treatments. Careful clinical evaluation should address all of these dimensions, recognizing that improvement may occur sooner in some symptoms (eg, mood) compared with others (eg, sleep disturbance).

scholarly journals Temporal Associations of Daily Changes in Sleep and Depression Core Symptoms in Patients Suffering From Major Depressive Disorder: Idiographic Time-Series Analysis

10.2196/17071 ◽  
2020 ◽  
Vol 7 (4) ◽  
pp. e17071
Author(s):  
Noah Lorenz ◽  
Christian Sander ◽  
Galina Ivanova ◽  
Ulrich Hegerl
Keyword(s):  
Time Series ◽  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Total Sleep Time ◽  
Sleep Time ◽  
The Other ◽  
Series Data ◽  
Major Depressive ◽  
Time In Bed ◽  
Core Symptoms

Background There is a strong link between sleep and major depression; however, the causal relationship remains unclear. In particular, it is unknown whether changes in depression core symptoms precede or follow changes in sleep, and whether a longer or shorter sleep duration is related to improvements of depression core symptoms. Objective The aim of this study was to investigate temporal associations between sleep and depression in patients suffering from major depressive disorder using an idiographic research approach. Methods Time-series data of daily sleep assessments (time in bed and total sleep time) and self-rated depression core symptoms for an average of 173 days per patient were analyzed in 22 patients diagnosed with recurrent major depressive disorder using a vector autoregression model. Granger causality tests were conducted to test for possible causality. Impulse response analysis and forecast error variance decomposition were performed to quantify the temporal mutual impact of sleep and depression. Results Overall, 11 positive and 5 negative associations were identified between time in bed/total sleep time and depression core symptoms. Granger analysis showed that time in bed/total sleep time caused depression core symptoms in 9 associations, whereas this temporal order was reversed for the other 7 associations. Most of the variance (10%) concerning depression core symptoms could be explained by time in bed. Changes in sleep or depressive symptoms of 1 SD had the greatest impact on the other variable in the following 2 to 4 days. Conclusions Longer rather than shorter bedtimes were associated with more depression core symptoms. However, the temporal orders of the associations were heterogeneous.

scholarly journals Efficacy of adjunctive brexpiprazole on the core symptoms of major depressive disorder: A post hoc analysis of two pooled clinical studies

2018 ◽  
Vol 227 ◽  
pp. 103-108 ◽  
Author(s):  
J. Craig Nelson ◽  
Emmanuelle Weiller ◽  
Peter Zhang ◽  
Catherine Weiss ◽  
Mary Hobart
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Clinical Studies ◽  
Major Depressive ◽  
Post Hoc Analysis ◽  
The Core ◽  
Post Hoc ◽  
Core Symptoms
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