Quantitative two-dimensional HRMAS 1H-NMR spectroscopy-based metabolite profiling of human cancer cell lines and response to chemotherapy

2010 ◽  
Vol 63 (5) ◽  
pp. 1172-1183 ◽  
Author(s):  
Mathilde Bayet-Robert ◽  
Dominique Loiseau ◽  
Pascale Rio ◽  
Aicha Demidem ◽  
Chantal Barthomeuf ◽  
...  
Keyword(s):  
Nmr Spectroscopy ◽  
Cell Lines ◽  
Cancer Cell ◽  
Metabolite Profiling ◽  
1H Nmr Spectroscopy ◽  
Human Cancer ◽  
Two Dimensional ◽  
Human Cancer Cell ◽  
Human Cancer Cell Lines ◽  
Response To Chemotherapy

Isolation, Structure, Synthesis and Cytotoxicity of an Unprecedented Flupirtine Dimer

2012 ◽  
Vol 67 (12) ◽  
pp. 1297-1304 ◽  
Author(s):  
René Csuk ◽  
Sven Sommerwerk ◽  
Jana Wiese ◽  
Christoph Wagner ◽  
Bianka Siewert ◽  
...  
Keyword(s):  
Nmr Spectroscopy ◽  
Cell Lines ◽  
Cancer Cell ◽  
Human Cancer ◽  
Human Cancer Cell ◽  
Target Compound ◽  
Mouse Fibroblasts ◽  
Human Cancer Cell Lines ◽  
Structure Synthesis ◽  
Independent Synthesis

A previously unknown dimer of the well-established analgesic flupirtine has been found, and its structure was revealed by ESI-MS, NMR spectroscopy and an independent synthesis. Thus, starting from 2-amino-6-chloro-3-nitro-pyridine the target compound was obtained in a four-step synthesis. Key-step of this synthesis is a nickel-mediated aryl-aryl coupling. The dimer 4 did not show any cytotoxicity, and its IC50 values were > 30 μm for all six human cancer cell lines and mouse fibroblasts used in this study

Constituents of Polyalthia jucunda and their cytotoxic effect on human cancer cell lines

Planta Medica ◽  
2007 ◽  
Vol 73 (09) ◽  
Author(s):  
IO Mondranondra ◽  
A Suedee ◽  
A Kijjoa ◽  
M Pinto ◽  
N Nazareth ◽  
...  
Keyword(s):  
Cell Lines ◽  
Cancer Cell ◽  
Cytotoxic Effect ◽  
Human Cancer ◽  
Cancer Cell Lines ◽  
Human Cancer Cell ◽  
Human Cancer Cell Lines

Design, Synthesis and Biological Evaluation of 3-(3,4,5-Trimethoxyphenyl)- 5-(2-(5-arylbenzo[b]thiophen-3-yl)oxazol-5-yl)isoxazole Derivatives as Anticancer Agents

2020 ◽  
Vol 17 (5) ◽  
pp. 345-351
Author(s):  
Syndla Premalatha ◽  
G. Rambabu ◽  
Islavathu Hatti ◽  
Dittakavi Ramachandran
Keyword(s):  
Breast Cancer ◽  
Anticancer Activity ◽  
Cell Lines ◽  
Cancer Cell ◽  
Human Cancer ◽  
Cancer Cell Lines ◽  
Biological Evaluation ◽  
Human Cancer Cell ◽  
Human Cancer Cell Lines ◽  
Isoxazole Derivatives

A new series of 3-(3,4,5-trimethoxyphenyl)-5-(2-(5-arylbenzo[b]thiophen-3-yl)oxa zol-5- yl)isoxazole derivatives were designed and synthesized. All these derivatives were evaluated for their anticancer activity against various human cancer cell lines such as MCF-7 (breast cancer), A549 (lung cancer), DU-145 (prostate cancer) and MDA MB-231 (breast cancer)-four human cancer cell lines by using MTT assay. Here, etoposide was used as a standard reference drug and most of the compounds were exhibited good anticancer activity with respect to cell lines. Among all compounds, five compounds 11b, 11c, 11f, 11i and 11j showed more potent activity than standard drug, in which, compound 11f was the most promising compound.

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