The follow-up of progressive hypertrophic cardiomyopathy using magnetic resonance rotating frame relaxation times

2017 ◽  
Vol 31 (2) ◽  
pp. e3871 ◽  
Author(s):  
Muhammad Arsalan Khan ◽  
Hanne Laakso ◽  
Svetlana Laidinen ◽  
Sanna Kettunen ◽  
Tommi Heikura ◽  
...  
Keyword(s):  
Hypertrophic Cardiomyopathy ◽  
Magnetic Resonance ◽  
Relaxation Times ◽  
Rotating Frame ◽  
Rotating Frame Relaxation

scholarly journals Endogenous T1ρ cardiovascular magnetic resonance in hypertrophic cardiomyopathy

2021 ◽  
Vol 23 (1) ◽  
Author(s):  
Elizabeth W. Thompson ◽  
Srikant Kamesh Iyer ◽  
Michael P. Solomon ◽  
Zhaohuan Li ◽  
Qiang Zhang ◽  
...  
Keyword(s):  
Cardiovascular Magnetic Resonance ◽  
Hypertrophic Cardiomyopathy ◽  
Magnetic Resonance ◽  
Extracellular Volume ◽  
Relaxation Times ◽  
Left Ventricular ◽  
Cardiomyocyte Hypertrophy ◽  
Short Axis ◽  
Spearman's Rho ◽  
Spearman’S Rho

Abstract Background Hypertrophic cardiomyopathy (HCM) is characterized by increased left ventricular wall thickness, cardiomyocyte hypertrophy, and fibrosis. Adverse cardiac risk characterization has been performed using late gadolinium enhancement (LGE), native T1, and extracellular volume (ECV). Relaxation time constants are affected by background field inhomogeneity. T1ρ utilizes a spin-lock pulse to decrease the effect of unwanted relaxation. The objective of this study was to study T1ρ as compared to T1, ECV, and LGE in HCM patients. Methods HCM patients were recruited as part of the Novel Markers of Prognosis in Hypertrophic Cardiomyopathy study, and healthy controls were matched for comparison. In addition to cardiac functional imaging, subjects underwent T1 and T1ρ cardiovascular magnetic resonance imaging at short-axis positions at 1.5T. Subjects received gadolinium and underwent LGE imaging 15–20 min after injection covering the entire heart. Corresponding basal and mid short axis LGE slices were selected for comparison with T1 and T1ρ. Full-width half-maximum thresholding was used to determine the percent enhancement area in each LGE-positive slice by LGE, T1, and T1ρ. Two clinicians independently reviewed LGE images for presence or absence of enhancement. If in agreement, the image was labeled positive (LGE + +) or negative (LGE −−); otherwise, the image was labeled equivocal (LGE + −). Results In 40 HCM patients and 10 controls, T1 percent enhancement area (Spearman’s rho = 0.61, p < 1e-5) and T1ρ percent enhancement area (Spearman’s rho = 0.48, p < 0.001e-3) correlated with LGE percent enhancement area. T1 and T1ρ percent enhancement areas were also correlated (Spearman’s rho = 0.28, p = 0.047). For both T1 and T1ρ, HCM patients demonstrated significantly longer relaxation times compared to controls in each LGE category (p < 0.001 for all). HCM patients also showed significantly higher ECV compared to controls in each LGE category (p < 0.01 for all), and LGE −− slices had lower ECV than LGE + + (p = 0.01). Conclusions Hyperenhancement areas as measured by T1ρ and LGE are moderately correlated. T1, T1ρ, and ECV were elevated in HCM patients compared to controls, irrespective of the presence of LGE. These findings warrant additional studies to investigate the prognostic utility of T1ρ imaging in the evaluation of HCM patients.

Measurement of Longitudinal and Rotating Frame Relaxation Times through Fully J-Decoupled Homonuclear Spectra

1999 ◽  
Vol 140 (1) ◽  
pp. 250-258 ◽  
Author(s):  
F. Guenneau ◽  
P. Mutzenhardt ◽  
D. Grandclaude ◽  
D. Canet
Keyword(s):  
Relaxation Times ◽  
Rotating Frame ◽  
Rotating Frame Relaxation

scholarly journals Patients who do not fulfill criteria for hypertrophic cardiomyopathy but have unexplained giant T-wave inversion: a cardiovascular magnetic resonance mid-term follow-up study

2021 ◽  
Vol 23 (1) ◽  
Author(s):  
Shuang Li ◽  
Jian He ◽  
Jing Xu ◽  
Baiyan Zhuang ◽  
Bailing Wu ◽  
...  
Keyword(s):  
Cardiovascular Magnetic Resonance ◽  
Hypertrophic Cardiomyopathy ◽  
Magnetic Resonance ◽  
Wall Thickness ◽  
Receiver Operating Curve ◽  
T Wave ◽  
Wave Inversion ◽  
The Mean ◽  
Over Time

Abstract Background Patients who have unexplained giant T-wave inversions but do not meet criteria for hypertrophic cardiomyopathy (HCM) (left ventricular (LV) wall thickness < 1.5 cm) demonstrate LV apical morphological features that differ from healthy subjects. Currently, it remains unknown how the abnormal LV apical morphology in this patient population changes over time. The purpose of this study was to investigate LV morphological and functional changes in these patients using a mid-term cardiovascular magnetic resonance (CMR) exam. Methods Seventy-one patients with unexplained giant T-wave inversion who did not fulfill HCM criteria were studied. The mean interval time of the follow-up CMR was 24.4 ± 8.3 months. The LV wall thickness was measured in each LV segment according to the American Heart Association 17-segmented model. The apical angle (ApA) was also measured. A receiver operating curve (ROC) was used to identify the predictive values of the CMR variables. Results Of 71 patients, 16 (22.5%) progressed to typical apical HCM, while 55 (77.5%) did not progress to HCM criteria. The mean apical wall thickness was significantly different between the two groups at both baseline and follow-up, with the apical HCM group having greater wall thickness at both time points (all p < 0.001). There was a significant difference between the two groups in the change of ApA (− 1.5 ± 2.7°/yr vs. − 0.7 ± 2.0°/yr, p < 0.001) over time. The combination of mean apical wall thickness and ApA proved to be the best predictor for fulfilling criteria for apical HCM with a threshold value of 8.1 mm and 90° (sensitivity 93.8%, specificity 85.5%). Conclusions CMR metrics identify predictors for progression to HCM in patients with unexplained giant T-wave inversion.

scholarly journals The Lindbladian Form And The Reincarnation of Felix Bloch's Generalized Theory of Relaxation

2021 ◽  
Author(s):  
Thomas Michael Barbara
Keyword(s):  
Magnetic Resonance ◽  
Density Matrix ◽  
Rotating Frame ◽  
Full Agreement ◽  
Relaxation Theory ◽  
Careful Scrutiny ◽  
New Birth ◽  
Modern Methods ◽  
Rotating Frame Relaxation ◽  
The Relationship

Abstract. The relationship between the classic magnetic resonance density matrix relaxation theories of Bloch and Hubbard, and the modern Lindbladian master equation methods are explored. These classic theories are in full agreement with the latest results obtained by the modern methods. A careful scrutiny shows that this also holds true for Redfield’s later treatment, offered in 1965. The early contributions of Bloch and Hubbard to rotating frame relaxation theory are also highlighted. Taken together, these seminal efforts of Bloch and Hubbard can enjoy a new birth of contemporary relevance in magnetic resonance.

Analysis of carbon-13 nuclear spin relaxation parameters, including rotating frame relaxation times, in a series of micellized sodium alkanoates

1993 ◽  
Vol 97 (37) ◽  
pp. 9513-9518 ◽  
Author(s):  
N. Mahieu ◽  
P. Tekely ◽  
J. C. Boubel ◽  
J. M. Cases ◽  
D. Canet
Keyword(s):  
Spin Relaxation ◽  
Nuclear Spin ◽  
Relaxation Times ◽  
Nuclear Spin Relaxation ◽  
Rotating Frame ◽  
Relaxation Parameters ◽  
Rotating Frame Relaxation

Follow-up of regional myocardial T2 relaxation times in patients with myocardial infarction evaluated with magnetic resonance imaging

1990 ◽  
Vol 11 (2) ◽  
pp. 110-119 ◽  
Author(s):  
X. Hanno Krauss ◽  
Ernst E. van der Wall ◽  
Arnoud van der Laarse ◽  
Joost Doornbos ◽  
Albert de Roos ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Myocardial Infarction ◽  
Magnetic Resonance ◽  
Relaxation Times ◽  
Resonance Imaging ◽  
T2 Relaxation

The Lindbladian form and the reincarnation of Felix Bloch's generalized theory of relaxation

2021 ◽  
Vol 2 (2) ◽  
pp. 689-698
Author(s):  
Thomas M. Barbara
Keyword(s):  
Magnetic Resonance ◽  
Density Matrix ◽  
Rotating Frame ◽  
Full Agreement ◽  
Relaxation Theory ◽  
Careful Scrutiny ◽  
New Birth ◽  
Modern Methods ◽  
Rotating Frame Relaxation ◽  
The Relationship

Abstract. The relationship between the classic magnetic resonance density matrix relaxation theories of Bloch and Hubbard and the modern Lindbladian master equation methods are explored. These classic theories are in full agreement with the latest results obtained by the modern methods. A careful scrutiny shows that this also holds true for Redfield's later treatment, offered in 1965. The early contributions of Bloch and Hubbard to rotating-frame relaxation theory are also highlighted. Taken together, these seminal efforts of Bloch and Hubbard can enjoy a new birth of contemporary relevance in magnetic resonance.

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