Optimal chemotherapy in cancer treatment: state dependent Riccati equation control and extended Kalman filter

2012 ◽  
Vol 34 (5) ◽  
pp. 562-577 ◽  
Author(s):  
Yazdan Batmani ◽  
Hamid Khaloozadeh
2015 ◽  
Vol 23 (01) ◽  
pp. 1-29 ◽  
Author(s):  
MOSTAFA NAZARI ◽  
ALI GHAFFARI ◽  
FARHAD ARAB

The main purpose of this paper is to propose an optimal finite duration treatment method for preventing tumor growth. The obtained results show that changing the dynamics of the cancer model is essential for a finite duration treatment. Therefore, vaccine therapy is used for changing the parameters of the system and chemotherapy is applied for pushing the system to the domain of attraction of the healthy state. The state-dependent Riccati equation (SDRE)-based optimal control method is used for optimal chemotherapy. In this method, the special conditions of the patients could be considered by choosing suitable weighting matrices in the cost function and restricting the drug dosage. Also, there are infinite ways to choose these state-dependent matrices. In this paper, these interesting features of this method are used for each patient. Since measuring the states of the system is impossible at each time for states feedback; an extended Kalman filter (EKF) is designed as an observer in the nonlinear system. So, the SDRE method is employed just by measuring the population of normal cells. Numerical simulations show the flexibility and effectiveness of this treatment method.


2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Ali Ghaffari ◽  
Mostafa Nazari ◽  
Farhad Arab

The main objective of this paper is to propose an optimal finite duration treatment method for cancer. A mathematical model is proposed to show the interactions between healthy and cancerous cells in the human body. To extend the existing models, the effect of vaccine therapy and chemotherapy are also added to the model. The equilibrium points and the related local stability are derived and discussed. It is shown that the dynamics of the cancer model must be changed and modified for finite treatment duration. Therefore, the vaccine therapy is used to change the parameters of the system and the chemotherapy is applied for pushing the system to the domain of attraction of the healthy state. For optimal chemotherapy, an optimal control is used based on state dependent Riccati equation (SDRE). It is shown that, in spite of eliminating the treatment, the system approaches the healthy state conditions. The results show that the development of optimal vaccine-chemotherapy protocols for removing tumor cells would be an appropriate strategy in cancer treatment. Also, the present study states that a proper treatment method not only reduces the population of the cancer cells but also changes the dynamics of the cancer.


2006 ◽  
Vol 4 (4) ◽  
pp. 377-379 ◽  
Author(s):  
Arsenia Chorti ◽  
Dimosthenis Karatzas ◽  
Neil M. White ◽  
Chris J. Harris

Author(s):  
Hamze Ahmadi Jeyed ◽  
Ali Ghaffari

In this article, for the first time, a novel nonlinear estimator based on state-dependent Riccati equation filter technique is developed for state estimation of the articulated heavy vehicles. The state-dependent Riccati equation filter approach has a structure similar to the Kalman filter, and compared to the Kalman filter, which is based on linearization, the state-dependent Riccati equation filter is based on parameterization. Also, the state-dependent Riccati equation approach due to the nonuniqueness of the state-dependent coefficient matrix prevented singularity (uncontrollability or unobservability), and this advantage can be used to improve the efficiency of the system. For this purpose, using the Newton's method, a ten-degrees-of-freedom nonlinear model of the articulated heavy vehicle including the longitudinal, lateral and yaw motion of the tractor, the articulation angle, and rotational motion of each wheel is developed. Then, the developed model of articulated heavy vehicle is verified using nonlinear TruckSim model in high-speed lane change maneuver. The vehicle model validation results indicated that the development model is near to the actual articulated vehicle nonlinear model and can be utilized in the nonlinear estimator design. Then, using the state-dependent Riccati equation filter approach, the state variable estimation algorithm based on parametrization is designed and the articulated vehicle states are estimated online. In order to assess the performance and the efficiency of the developed estimator, the simulations with two standard maneuvers including low-speed 90 ° turn maneuver and high-speed lane change maneuver in the slippery road are performed. The simulation results indicate the remarkable impacts of the developed estimator based on state-dependent Riccati equation filter technique on the state estimation of the articulated heavy vehicles.


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