scholarly journals Cancer of Unknown Primary Presenting as Bone‐Predominant or Lymph Node‐Only Disease: A Clinicopathologic Portrait

2021 ◽  
Author(s):  
Ryan W. Huey ◽  
Brandon G. Smaglo ◽  
Jeannelyn S. Estrella ◽  
Aurelio Matamoros ◽  
Michael J. Overman ◽  
...  
Keyword(s):  
Lymph Node ◽  
Cancer Of Unknown Primary ◽  
Unknown Primary

scholarly journals A Study on Cervical Lymph Node Metastasis from Cancer of Unknown Primary Origin

2014 ◽  
Vol 138 (0) ◽  
pp. 108-109
Author(s):  
Takashi Taniyama ◽  
Tomonori Sugiyama ◽  
Mamika Araki ◽  
Kouhei Fukukita ◽  
Hiroyuki Yamada ◽  
...  
Keyword(s):  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Cervical Lymph Node ◽  
Cervical Lymph Node Metastasis ◽  
Cancer Of Unknown Primary ◽  
Unknown Primary ◽  
Node Metastasis ◽  
Primary Origin ◽  
Unknown Primary Origin

The Added Value of [68Ga]Ga-DOTA-FAPI-04 PET/CT in Patients with Head and Neck Cancer of Unknown Primary with [18F]FDG Negative Findings

2021 ◽  
Author(s):  
Bingxin Gu ◽  
Xiaoping Xu ◽  
Ji Zhang ◽  
Xiaomin Ou ◽  
Zuguang Xia ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Lymph Node ◽  
Bone Metastases ◽  
Head And Neck ◽  
Primary Tumor ◽  
Cancer Of Unknown Primary ◽  
Unknown Primary ◽  
Primary Tumors ◽  
Pet Ct ◽  
The Mean

Abstract Purpose [18F]fluorodeoxyglucose ([18F]FDG) positron emission tomography/computed tomography (PET/CT) plays an important role in location of primary tumor for patients with head and neck cancer of unknown primary (HNCUP). But sometimes, [18F]FDG PET/CT still cannot find the primary malignancy. As 68Ga-radiolabeled fibroblast activation protein inhibitor (FAPI) PET/CT has promising results in detecting different tumor entities, our study aimed to evaluate the performance of [68Ga]Ga-DOTA-FAPI-04 PET/CT for detecting the primary tumor in HNCUP patients with negative [18F]FDG findings.Methods A total of eighteen patients (16 males and 2 females; median age, 55 years; range, 24-72 years) with negative [18F]FDG findings were eligible in this study. All patients underwent [18F]FDG and [68Ga]Ga-DOTA-FAPI-04 PET/CT within one week. Biopsy and histopathological examinations were done in the sites with positive [68Ga]Ga-DOTA-FAPI-04 PET/CT findings. Results [68Ga]Ga-DOTA-FAPI-04 PET/CT detected the primary tumor in 7 of 18 patients (38.89%). The primary tumors sites were in nasopharynx (1/7), palatine tonsil (2/7), submandibular gland (2/7), and hypopharynx (2/7). The primary tumors showed mild to intensive uptake of FAPI (mean SUVmax, 8.79; range, 2.60-16.50) and excellent tumor-to-contralateral normal tissue ratio (mean SUVmax ratio, 4.50; range, 2.17-8.21). In lesion-based analysis, a total of 65 lymph nodes and 17 bone metastatic lesions were identified. The mean SUVmax of lymph node metastases were 9.05 ± 5.29 for FDG and 9.08 ± 4.69 for FAPI (p = 0.975); as for bone metastases, the mean SUVmax were 8.11 ± 3.00 for FDG and 6.96 ± 5.87 for FAPI, respectively (p = 0.478). The mean tumor-to-background ratio (TBR) values of lymph node and bone metastases were 10.65 ± 6.59 vs. 12.80 ± 8.11 (p = 0.100) and 9.08 ± 3.35 vs. 9.14 ± 8.40 (p = 0.976), respectively.Conclusion We present first evidence of diagnostic role of [68Ga]Ga-DOTA-FAPI-04 PET/CT in HNCUP, and our study demonstrated that [68Ga]Ga-DOTA-FAPI-04 PET/CT had the potential to improve the detection rate of primary tumor in HNCUP patients with negative FDG findings. Moreover, [68Ga]Ga-DOTA-FAPI-04 had similar performance in assessing metastases with [18F]FDG.

scholarly journals Cisplatin plus Docetaxel Chemotherapy for Thoracic Lymph Node Metastasis from Cancer of Unknown Primary – Experience of Three Cases

2009 ◽  
Vol 2 (2) ◽  
pp. 84-91
Author(s):  
Takashi Kobayashi ◽  
Tomonobu Koizumi ◽  
Akihiro Kitaguchi ◽  
Orie Hatayama ◽  
Kenji Tsushima ◽  
...  
Keyword(s):  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Cancer Of Unknown Primary ◽  
Unknown Primary ◽  
Node Metastasis ◽  
Thoracic Lymph Node ◽  
Docetaxel Chemotherapy

Sentinel lymph node as a clue to the primary site of cancer of unknown primary.

2018 ◽  
Vol 36 (15_suppl) ◽  
pp. e24015-e24015
Author(s):  
Yilin Shao ◽  
Xin Liu ◽  
Silong Hu ◽  
Yingjian Zhang ◽  
Wentao Li ◽  
...  
Keyword(s):  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Cancer Of Unknown Primary ◽  
Primary Site ◽  
Unknown Primary
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