Importance of voriconazole therapeutic drug monitoring in pediatric cancer patients with invasive aspergillosis

2012 ◽  
Vol 60 (1) ◽  
pp. 82-87 ◽  
Author(s):  
Soo-Han Choi ◽  
Soo-Youn Lee ◽  
Ji-Young Hwang ◽  
Soo Hyun Lee ◽  
Keon Hee Yoo ◽  
...  
Keyword(s):  
Therapeutic Drug Monitoring ◽  
Invasive Aspergillosis ◽  
Cancer Patients ◽  
Pediatric Cancer ◽  
Drug Monitoring ◽  
Therapeutic Drug ◽  
Pediatric Cancer Patients

scholarly journals Insufficient Fluconazole Exposure in Pediatric Cancer Patients and the Need for Therapeutic Drug Monitoring in Critically Ill Children

2014 ◽  
Vol 59 (11) ◽  
pp. 1527-1533 ◽  
Author(s):  
Kim C. M. van der Elst ◽  
Marieke Pereboom ◽  
Edwin R. van den Heuvel ◽  
Jos G. W. Kosterink ◽  
Elisabeth H. Schölvinck ◽  
...  
Keyword(s):  
Therapeutic Drug Monitoring ◽  
Cancer Patients ◽  
Critically Ill ◽  
Pediatric Cancer ◽  
Drug Monitoring ◽  
Critically Ill Children ◽  
Therapeutic Drug ◽  
Pediatric Cancer Patients

Therapeutic drug monitoring in the treatment of invasive aspergillosis with voriconazole in cancer patients—an evidence-based approach

2015 ◽  
Vol 94 (4) ◽  
pp. 547-556 ◽  
Author(s):  
Meinolf Karthaus ◽  
Thomas Lehrnbecher ◽  
Hans-Peter Lipp ◽  
Stefan Kluge ◽  
Dieter Buchheidt
Keyword(s):  
Therapeutic Drug Monitoring ◽  
Invasive Aspergillosis ◽  
Cancer Patients ◽  
Drug Monitoring ◽  
Therapeutic Drug ◽  
Evidence Based

scholarly journals Is It Time for Systematic Voriconazole Pharmacogenomic Investigation for Central Nervous System Aspergillosis?

2018 ◽  
Vol 62 (9) ◽  
Author(s):  
François Danion ◽  
Vincent Jullien ◽  
Claire Rouzaud ◽  
Manal Abdel Fattah ◽  
Simona Lapusan ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Therapeutic Drug Monitoring ◽  
Invasive Aspergillosis ◽  
Drug Monitoring ◽  
Standard Treatment ◽  
Plasma Concentrations ◽  
Therapeutic Drug ◽  
Life Threatening ◽  
Trough Plasma

ABSTRACT Voriconazole is the standard treatment for invasive aspergillosis but requires therapeutic drug monitoring to optimize therapy. We report two cases of central nervous system aspergillosis treated with voriconazole. Because of low trough plasma concentrations, we identified gain-of-function mutations in CYP2C19 that were partially responsible for the therapeutic failure of voriconazole. We suggest that systematic voriconazole pharmacogenomic investigation of cerebral aspergillosis be performed to avoid effective therapy delay in this life-threatening disease.

scholarly journals Vincristine dosing, drug exposure and therapeutic drug monitoring in neonate and infant cancer patients

2021 ◽  
Author(s):  
Shelby Barnett ◽  
Farina Hellmann ◽  
Elizabeth Parke ◽  
Guy Makin ◽  
Deborah A. Tweddle ◽  
...  
Keyword(s):  
Therapeutic Drug Monitoring ◽  
Cancer Patients ◽  
Drug Monitoring ◽  
Drug Exposure ◽  
Therapeutic Drug
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