scholarly journals Single‐center experience suggests donor lymphocyte infusion may promote long‐term survival in children with high‐risk acute lymphoblastic leukemia

2019 ◽  
Vol 66 (11) ◽  
Author(s):  
Nicole Liberio ◽  
Haley Robinson ◽  
Melodee Nugent ◽  
Pippa Simpson ◽  
David A. Margolis ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
High Risk ◽  
Lymphoblastic Leukemia ◽  
Donor Lymphocyte Infusion ◽  
Single Center ◽  
Term Survival ◽  
Long Term Survival ◽  
Single Center Experience

scholarly journals Long-Term Survival in Pediatric Heart Transplantation: A 35-Year Single-Center Experience

2021 ◽  
Vol 40 (4) ◽  
pp. S34
Author(s):  
J.W. Wen ◽  
M.E. Richmond ◽  
S.P. Law ◽  
T.M. Lee ◽  
I.D. Lytrivi ◽  
...  
Keyword(s):  
Heart Transplantation ◽  
Single Center ◽  
Term Survival ◽  
Long Term Survival ◽  
Single Center Experience ◽  
Pediatric Heart Transplantation

scholarly journals The Colony-Stimulating Factor 3 Receptor M696T Mutated in a Patient with Ph+ Acute Lymphoblastic Leukemia

Blood ◽  
2020 ◽  
Vol 136 (Supplement 1) ◽  
pp. 13-13
Author(s):  
Xin Chen ◽  
Bichen Wang ◽  
Aiming Pang ◽  
Erlie Jiang ◽  
Yajing Chu ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Lymphoblastic Leukemia ◽  
Myelogenous Leukemia ◽  
Unrelated Donor ◽  
Colony Stimulating Factor ◽  
Term Survival ◽  
Long Term Survival ◽  
Tumor Transformation ◽  
Stimulating Factor

Purpose: Colony-stimulating factor 3 receptor (CSF3R) mutations have been identified in a variety of myeloid disorders, such as severe congenital neutropenia (SCN), chronic neutrophilic leukemia (CNL), myelodysplastic syndrome (MDS), acute myeloid leukemia (AML), and atypical chronic myelogenous leukemia (aCML). Although CSF3R point mutations (e.g., T618I) are emerging as key players in CNL/aCML, the significance of rarer CSF3R mutations is unknown. We report a case of philadelphia chromosome positive acute lymphoblastic leukemia (Ph+ ALL) with the M696T mutation in CSF3R gene and assess the pathogenicity of the CSF3R M696T mutation in Ph+ ALL. Experimental Design: Here we report on a 32-year-old female who presented with asthenia. The initial hematological workup revealed white blood cell (WBC) count of 97 x 109/L (normal range 4-10 x 109/L). There was 84% prolymphocyte in the bone marrow. The immunophenotype of the blasts as judged from flow cytometry was in accordance with a B-ALL. The fusion gene for BCR-ABL P210 was positive. Hot mutation closely related to diseases was: CSF3R (nucleotide change c.2087 T>C, amino acid change p.M696T, mutation frequency 50.4%). Cytogenetic analysis showed 46, XX, t (9;22) (q34;q11). The patient was diagnosed as Ph+ ALL with the CSF3R M696T mutation and achieved Long-term survival after unrelated donor hematopoietic stem cell transplantation. Meanwhile we performed a series of experiments using murine interleukin 3 (IL-3)-dependent Ba/F3 cell line to evaluate the transforming capacity of the CSF3R M696T mutation. The phosphorylation of STAT3 was analyzed by G-CSF dependence assays and immunoblot analysis to evaluate the CSF3R M696T mutation contribution to the tumor transformation ability of Ba/F3 cells. Results: This patient achieved complete remission with chemotherapy in combination with tyrosine kinase inhibitor (TKI) and long-term survival by unrelated donor transplantation. We confirmed the presence of a CSF3R M696T germline mutation in this patient, and the mutation was inherited from her mother. The experiments in vitro result showed the CSF3R M696T mutation harbors marginal contribution to the tumor transformation ability of Ba/F3 cells. CSF3R M696T mutation was neutral in tumor transformation ability. Conclusions: We believe that TKI is still effective in patients with the CSF3R M696T mutation in Ph+ ALL. Donor with CSF3R M696T mutation might still be selected. Disclosures No relevant conflicts of interest to declare.

scholarly journals Morbidity, mortality and long term survival in patients with vascular resection in pancreatic cancer – single center experience

Neoplasma ◽  
2017 ◽  
Vol 64 (03) ◽  
pp. 460-463 ◽  
Author(s):  
D. Pindak ◽  
M. Tomas ◽  
J. Dolnik ◽  
R. Duchon ◽  
J. Pavlendova
Keyword(s):  
Pancreatic Cancer ◽  
Vascular Resection ◽  
Single Center ◽  
Term Survival ◽  
Long Term Survival ◽  
Single Center Experience

Long-term survival in multiple myeloma: a single-center experience

2008 ◽  
Vol 8 (3) ◽  
pp. 133-139 ◽  
Author(s):  
Francesca Merchionne ◽  
Pasquale Procaccio ◽  
Franco Dammacco
Keyword(s):  
Multiple Myeloma ◽  
Single Center ◽  
Term Survival ◽  
Long Term Survival ◽  
Single Center Experience

Long term follow-up of treatment of adult acute lymphoblastic leukemia with two protocols, LALA87 and YUALL. Single center experience

1999 ◽  
Vol 35 ◽  
pp. S338
Author(s):  
M. Colovic ◽  
A. Bogdanovic ◽  
G. Jankovic ◽  
D. Tomin ◽  
N. Kraguljac ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Lymphoblastic Leukemia ◽  
Single Center ◽  
Single Center Experience ◽  
Adult Acute Lymphoblastic Leukemia ◽  
Long Term Follow Up

Long-term Survival in Patients Undergoing Radical Nephrectomy and Inferior Vena Cava Thrombectomy: Single-Center Experience

2010 ◽  
Vol 57 (4) ◽  
pp. 667-672 ◽  
Author(s):  
Gaetano Ciancio ◽  
Murugesan Manoharan ◽  
Devendar Katkoori ◽  
Rosely De Los Santos ◽  
Mark S. Soloway
Keyword(s):  
Inferior Vena Cava ◽  
Radical Nephrectomy ◽  
Inferior Vena ◽  
Vena Cava ◽  
Single Center ◽  
Term Survival ◽  
Long Term Survival ◽  
Single Center Experience

Factors Influencing Long-Term Survival of Kidney Grafts Transplanted From Deceased Donors—Analysis Based on a Single-Center Experience

2018 ◽  
Vol 50 (5) ◽  
pp. 1281-1284
Author(s):  
K. Dziewanowski ◽  
M. Myślak ◽  
R. Drozd ◽  
E. Krzystolik ◽  
A. Krzystolik ◽  
...  
Keyword(s):  
Single Center ◽  
Term Survival ◽  
Long Term Survival ◽  
Single Center Experience ◽  
Factors Influencing ◽  
Deceased Donors

Immunologic events and long-term survival after combined heart and kidney transplantation: a 12-year single-center experience

2001 ◽  
Vol 20 (10) ◽  
pp. 1084-1091 ◽  
Author(s):  
Emmanuelle Vermès ◽  
Matthias Kirsch ◽  
Rémi Houël ◽  
Sabine Legouvelo ◽  
Christophe Benvenuti ◽  
...  
Keyword(s):  
Kidney Transplantation ◽  
Single Center ◽  
Term Survival ◽  
Long Term Survival ◽  
Single Center Experience
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