Long-term risk of portal hypertension and related complications in children treated with 6-thioguanine for acute lymphoblastic leukemia: A single-center experience

2017 ◽  
Vol 64 (10) ◽  
pp. e26495 ◽  
Author(s):  
Nirmalya Roy Moulik ◽  
Mary M Taj
Keyword(s):  
Portal Hypertension ◽  
Acute Lymphoblastic Leukemia ◽  
Lymphoblastic Leukemia ◽  
Single Center ◽  
Single Center Experience

Long term follow-up of treatment of adult acute lymphoblastic leukemia with two protocols, LALA87 and YUALL. Single center experience

1999 ◽  
Vol 35 ◽  
pp. S338
Author(s):  
M. Colovic ◽  
A. Bogdanovic ◽  
G. Jankovic ◽  
D. Tomin ◽  
N. Kraguljac ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Lymphoblastic Leukemia ◽  
Single Center ◽  
Single Center Experience ◽  
Adult Acute Lymphoblastic Leukemia ◽  
Long Term Follow Up

Long-Term Results Of Allogeneic Stem Cell Transplantation In 56 Adult Patients With Philadelphia-Positive Acute Lymphoblastic Leukemia: A 20-Year Single Center Experience

Blood ◽  
2013 ◽  
Vol 122 (21) ◽  
pp. 5521-5521
Author(s):  
Adalberto Ibatici ◽  
Fabio Guolo ◽  
Federica Galaverna ◽  
Clara Delle Piane ◽  
Alida Dominietto ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Retrospective Analysis ◽  
Induction Therapy ◽  
Lymphoblastic Leukemia ◽  
Adult Patients ◽  
Long Term Results ◽  
Prognostic Impact ◽  
Single Center ◽  
Single Center Experience

Abstract Background Despite the great clinical benefit from the advent of tyrosine-kinase inhibitors (TKIs) treatment for adult patients with Philadelphia-positive acute lymphoblastic leukemia (Ph+ ALL), allogeneic hematopoietic stem cells transplantation (allo-HSCT) does not appear to be dispensable, if the optimal long-term outcome is to be achieved. However, there are only few data reported on long-term survivors with Ph+ ALL, particularly for those not receiving pre-transplant TKIs in the conventional induction therapy. In this retrospective analysis, we report on the long term outcomes of myeloablative allo-HSCT during the past 2 decades as single center experience. Data on the use of post-transplant TKIs and molecular monitoring for minimal residual disease are being collected to investigate their predictive role. Patients and methods Between 1989 and 2013, we collected 56 patients who underwent myeloablative allo-HSCT from HLA-identical siblings (n: 24), unrelated donors (n: 17), alternative donors (n: 15). Median age was 41 years (16-64). Disease phase at transplant was CR1 in 30 pts (53%), >CR1 in 26 pts. Pre-transplant TKI as part of induction therapy was given in 25 pts (44%). Conditioning regimen was TBI-based in 47 pts (83%) and chemotherapy-based in 9 pts. GVHD prophylaxis was given according to Center standard practice. Results Median follow-up was 67 months (1- 244). There were no cases of primary graft failure. Incidence of grade II-IV acute GVHD occurred in 31 pts (55%) and extensive chronic GVHD in 18 pts (32%). Transplant-related mortality was 35% at 2 years and 7 more patients died of non-relapse causes up to 12 years after transplant. The 10-year OS was 25% and significantly better for patients in CR1 vs. >CR1 (36% VS 14% - p=0,006). The 10-year DFS was 27% with no statistical difference for pts in CR1 vs. >CR1. Age at transplant and pre-transplant TKI did not affect the outcomes. Conclusions In this retrospective analysis over a 20-year time period, we show that approximately one-third of adult Ph+ ALL are cured if they undergo allo-HSCT in CR1. Therefore, we confirm that disease status at transplant has a major prognostic impact on clinical outcomes. The apparent lack of benefit of pre-transplant TKI exposure may be due to the retrospective nature of the analysis. Disclosures: No relevant conflicts of interest to declare.

scholarly journals Single‐center experience suggests donor lymphocyte infusion may promote long‐term survival in children with high‐risk acute lymphoblastic leukemia

2019 ◽  
Vol 66 (11) ◽  
Author(s):  
Nicole Liberio ◽  
Haley Robinson ◽  
Melodee Nugent ◽  
Pippa Simpson ◽  
David A. Margolis ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
High Risk ◽  
Lymphoblastic Leukemia ◽  
Donor Lymphocyte Infusion ◽  
Single Center ◽  
Term Survival ◽  
Long Term Survival ◽  
Single Center Experience

Comprehensive analysis of Methylenetetrahydrofolate reductase C677T in younger acute lymphoblastic leukemia patients: A single-center experience

2018 ◽  
Vol 25 (5) ◽  
pp. 1182-1186 ◽  
Author(s):  
Rim Frikha ◽  
Tarek Rebai ◽  
Ben Mahmoud Lobna ◽  
Fakher Frikha ◽  
Moez Mdhaffar ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Methylenetetrahydrofolate Reductase ◽  
Lymphoblastic Leukemia ◽  
Comprehensive Analysis ◽  
Single Center ◽  
Single Center Experience

Outcomes of adult acute lymphoblastic leukemia in the era of pediatric-inspired regimens: a single-center experience

2019 ◽  
Vol 110 (3) ◽  
pp. 295-305 ◽  
Author(s):  
Adisak Tantiworawit ◽  
Thanawat Rattanathammethee ◽  
Chatree Chai-Adisaksopha ◽  
Ekarat Rattarittamrong ◽  
Lalita Norasetthada
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Lymphoblastic Leukemia ◽  
Single Center ◽  
Single Center Experience ◽  
Adult Acute Lymphoblastic Leukemia

Chromosomal aberrations in childhood acute lymphoblastic leukemia: 15-year single center experience

2016 ◽  
Vol 209 (7-8) ◽  
pp. 340-347 ◽  
Author(s):  
Marie Jarosova ◽  
Jana Volejnikova ◽  
Ilona Porizkova ◽  
Milena Holzerova ◽  
Dagmar Pospisilova ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Chromosomal Aberrations ◽  
Lymphoblastic Leukemia ◽  
Childhood Acute Lymphoblastic Leukemia ◽  
Single Center ◽  
Single Center Experience

scholarly journals Dengue fever as a cause of febrile neutropenia in adult acute lymphoblastic leukemia: A single center experience

2014 ◽  
Vol 7 (3) ◽  
pp. 125-126 ◽  
Author(s):  
Hasmukh Jain ◽  
Manju Sengar ◽  
Hari Menon ◽  
Uma Dangi ◽  
Sanjay Biswas ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Febrile Neutropenia ◽  
Dengue Fever ◽  
Lymphoblastic Leukemia ◽  
Single Center ◽  
Single Center Experience ◽  
Adult Acute Lymphoblastic Leukemia
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