Metabolic differentiation and quantification of gymnemic acid in Gymnema sylvestre (Retz.) R.Br. ex Sm. leaf extract and its fermented products

2020 ◽  
Vol 31 (4) ◽  
pp. 488-500
Author(s):  
Jalaluddin Khan ◽  
Sunita Sheoran ◽  
Washim Khan ◽  
Bibhu Prasad Panda
Keyword(s):  
Leaf Extract ◽  
Gymnema Sylvestre ◽  
Gymnemic Acid ◽  
Fermented Products

scholarly journals Methanolic leaf extract of Gymnema sylvestre augments glucose uptake and ameliorates Insulin resistance by upregulating GLUT-4, PPAR- and #947;, adiponectin and leptin levels in vitro

2016 ◽  
Vol 5 (2) ◽  
pp. 146 ◽  
Author(s):  
Puttanarasaiah Kumar ◽  
Marikunte Venkataranganna ◽  
Kirangadur Manjunath ◽  
Gollapalle Viswanatha ◽  
Godavarthi Ashok
Keyword(s):  
Insulin Resistance ◽  
Glucose Uptake ◽  
Leaf Extract ◽  
Gymnema Sylvestre ◽  
Glut 4

scholarly journals In Vitro Antioxidant and Anti-Diabetic Potential of Gymnema Sylvestre Methanol Leaf Extract

2017 ◽  
Vol 13 (36) ◽  
pp. 218 ◽  
Author(s):  
Ibrahim A. ◽  
Babandi A. ◽  
Tijjani A.A. ◽  
Murtala Y. ◽  
Yakasai H.M. ◽  
...  
Keyword(s):  
Normal Control ◽  
Leaf Extract ◽  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Significant Inhibition ◽  
Alpha Amylase ◽  
Gymnema Sylvestre ◽  
Total Flavonoids Content

Some medicinal plants and their purified derivatives have demonstrated beneficial therapeutic potentials for many centuries. They have been reported to exhibit antioxidant activity, reducing the oxidative stress in cells and are therefore useful in the treatment of many human diseases, including diabetes and other non-communicable diseases. This study evaluated antioxidative activity and enzymatic (alpha-amylase and alphaglucosidase) inhibitory potentials of Gymnema sylvestre methanolic leaf extract (GSMLE) using standard methods. Phytochemical screening revealed the presence of alkaloids, tannins, saponins, steroids, terpenoids and flavonoids. The total phenolics and total flavonoids content in the extract were found to be 6.629±0.745 (µg/ml of catechol equivalent) and 0.004±0.0012 (µg/ml of quercetin equivalent) respectively. GSMLE was shown to have radical scavenging activity against DPPH (290.54 ± 39.72 %), hydroxyl radical (86.507 ± 23.55 %) and hydrogen peroxide (45.25 ± 25.23 %). The level of SOD was significantly decreased in H2O2 induced and H2O2+extract induced when compared with normal control (p<0.05); the level of GSH was significantly increased in H2O2 induced control and significantly decreased in H2O2+extract induced test when compared to normal control. GSH was also decreased significantly in H2O2+extract induced when compared to H2O2 induced control (p<0.05). The extract also demonstrated significant inhibition of alpha-glucosidase (IC50 182.26 ±1.05μg/ml) when compared with standard acarbose (IC50 189.52±0.46) and was more potent than the arcarbose on alpha-amylase inhibition with IC50 of 195.3±4.40 and 200.05±7.16 respectively. These findings may therefore, stress the potentiality of using Gymnema sylvestre as a natural remedy for the management of type 2 diabetes.

Improved gymnemic acid production in the suspension cultures of Gymnema sylvestre through biotic elicitation

2013 ◽  
Vol 7 (4) ◽  
pp. 519-525 ◽  
Author(s):  
Bhuvaneswari Chodisetti ◽  
Kiranmayee Rao ◽  
Suryakala Gandi ◽  
Archana Giri
Keyword(s):  
Acid Production ◽  
Suspension Cultures ◽  
Gymnema Sylvestre ◽  
Gymnemic Acid ◽  
Biotic Elicitation

Gymnemic Acid Production in Suspension Cell Cultures of Gymnema sylvestre

2006 ◽  
Vol 6 (10) ◽  
pp. 2263-2268 ◽  
Author(s):  
C. Subathra Devi ◽  
S. Murugesh . ◽  
V. Mohana Srinivasan .
Keyword(s):  
Cell Cultures ◽  
Acid Production ◽  
Suspension Cell ◽  
Gymnema Sylvestre ◽  
Gymnemic Acid ◽  
Suspension Cell Cultures

Use of Gymnema sylvestre leaf extract in the control of blood glucose in insulin-dependent diabetes mellitus

1990 ◽  
Vol 30 (3) ◽  
pp. 281-294 ◽  
Author(s):  
E.R.B. Shanmugasundaram ◽  
G. Rajeswari ◽  
K. Baskaran ◽  
B.R.Rajesh Kumar ◽  
K.Radha Shanmugasundaram ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Leaf Extract ◽  
Insulin Dependent Diabetes Mellitus ◽  
Insulin Dependent Diabetes ◽  
Dependent Diabetes Mellitus ◽  
Gymnema Sylvestre ◽  
Insulin Dependent

scholarly journals Immunomodulatory Effect of Gymnema sylvestre (R.Br.) Leaf Extract: An In Vitro Study in Rat Model

PLoS ONE ◽  
2015 ◽  
Vol 10 (10) ◽  
pp. e0139631 ◽  
Author(s):  
Vineet Kumar Singh ◽  
Padmanabh Dwivedi ◽  
B. R. Chaudhary ◽  
Ramesh Singh
Keyword(s):  
Rat Model ◽  
Leaf Extract ◽  
In Vitro Study ◽  
Vitro Study ◽  
Immunomodulatory Effect ◽  
Gymnema Sylvestre

Distribution of gymnemic acid in various organs of Gymnema sylvestre

2009 ◽  
Vol 20 (3) ◽  
pp. 268-270 ◽  
Author(s):  
Shirugumbi Hanamanthagouda Manohar ◽  
Poornananda Madhava Naik ◽  
Nagella Praveen ◽  
Hosakatte Niranjana Murthy
Keyword(s):  
Gymnema Sylvestre ◽  
Gymnemic Acid
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