scholarly journals Risk of second breast cancer events with chronic opioid use in breast cancer survivors

2019 ◽  
Vol 28 (5) ◽  
pp. 740-753 ◽  
Author(s):  
Denise M. Boudreau ◽  
Lu Chen ◽  
Onchee Yu ◽  
Erin J. Aiello Bowles ◽  
Jessica Chubak
Keyword(s):  
Breast Cancer ◽  
Cancer Survivors ◽  
Breast Cancer Survivors ◽  
Opioid Use ◽  
Chronic Opioid Use ◽  
Second Breast Cancer

scholarly journals Mental Health Comorbidities and Elevated Risk of Opioid Use in Elderly Breast Cancer Survivors Using Adjuvant Endocrine Treatments

2019 ◽  
Vol 15 (9) ◽  
pp. e777-e786 ◽  
Author(s):  
Raj Desai ◽  
Fabian Camacho ◽  
Xi Tan ◽  
Virginia LeBaron ◽  
Leslie Blackhall ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Mental Health ◽  
Cancer Survivors ◽  
Breast Cancer Survivors ◽  
Comorbid Condition ◽  
Adult Women ◽  
Fee For Service ◽  
Opioid Use ◽  
Risk Adjustment Model ◽  
Health Comorbidities

PURPOSE: Prolonged opioid use is common and associated with lower survival rates in breast cancer survivors. We explored whether opioid use in elderly breast cancer survivors using adjuvant endocrine therapy (AET) regimens was affected by the prevalence of mental health comorbidity and, in turn, how this affected survival in this population. METHODS: This retrospective study analyzed 2006 to 2012 SEER-Medicare data sets and followed patients for at least 2 years from the index date, defined as the first date they filled an AET prescription. The study included adult women with incident, primary, hormone receptor–positive, stage I to III breast cancer. They were also first-time AET users and fee-for-service Medicare enrollees continuously enrolled in Medicare Parts A, B, and D. We measured whether patients with a clinical diagnosis of a mental health comorbid condition used opioids after the initiation of AET and their survival at the end of the study period. RESULTS: A total of 10,452 breast cancer survivors who began AET treatments were identified, among whom the most commonly diagnosed mental health comorbidities were depression (n = 554) and anxiety (n = 246). Using a propensity score risk adjustment model, we found that opioid use was significantly higher in women with a mental health comorbidity (odds ratio,1.33; 95% CI, 1.06 to 1.68). In addition, mental health comorbidity was associated with a significantly increased hazard of mortality in this population (hazard ratio, 1.49; 95% CI, 1.02 to 2.18). CONCLUSION: The presence of mental health comorbidity in breast cancer survivors significantly increases the risk of opioid use and mortality, which highlights the need for better management of comorbid mental health conditions.

The impact of the use of opioids among older breast cancer survivors and adverse events.

2020 ◽  
Vol 38 (15_suppl) ◽  
pp. 12098-12098
Author(s):  
Aaron N Winn ◽  
Devon Check ◽  
Nicole Fergestrom ◽  
Joan Marie Neuner ◽  
Andrew Roberts
Keyword(s):  
Breast Cancer ◽  
Substance Use ◽  
Adverse Event ◽  
Adverse Events ◽  
Cancer Survivors ◽  
Cancer Treatment ◽  
Older Adult ◽  
Breast Cancer Survivors ◽  
Opioid Use ◽  
Active Cancer

12098 Background: Older adults and cancer survivors are underrepresented in the literature underpinning recent opioid prescribing guidelines. As prevention of unnecessary persistent opioid use and inadvertent opioid-related harms gains importance in clinical practice, it is necessary to fully capture the risks of opioid related adverse events among patients with cancer pain. The objective of this study was to determine the association between opioid use after cancer diagnosis and comprehensive opioid-related adverse events among older adult breast cancer survivors. Methods: We conducted a retrospective cohort study using Surveillance, Epidemiology, and End Results tumor registry data linked with Medicare administrative claims data from 2007-2016 of women with newly diagnosed non-metastatic breast cancer. The study observation period was the year following a patient’s end of active cancer treatment. The primary exposure was a daily measure of opioid exposure based on Part D prescription claims. The primary outcomes were daily indicators of all-cause hospitalization, substance use event and a composite of other opioid-related adverse events (infections, gastrointestinal events, falls/fractures, cardiovascular events) and each component of the composite adverse event. We estimated the association of current opioid use and the immediate risk of an outcome event the following day using modified Poisson generalized estimating equation models. We adjusted for patient demographics, cancer characteristics and cancer treatments received. Results: We found that opioid exposure more than doubled the immediate risk of all-cause hospitalization (aRR = 2.77; 95%CI = 2.57, 2.99; p < 0.001) and having a composite adverse event (aRR = 2.50; 95%CI = 2.18, 2.87; p < 0.001) and dramatically increases the immediate risk of a substance use event (aRR = 14.26; 95%CI = 7.11, 28.59; p < 0.001). We find consistent results when looking at individual components of the composite adverse event measure. Conclusions: Older adult breast cancer survivors with continued prescription opioid use in the year after completing active cancer treatment experienced an immediate increased risk of all-cause hospitalization, substance use events, and myriad opioid-related adverse effects.

scholarly journals PHP25 - MENTAL HEALTH COMORBIDITIES AND ELEVATED RISK OF OPIOID USE IN ELDERLY BREAST CANCER SURVIVORS USING ADJUVANT ENDOCRINE TREATMENTS

2018 ◽  
Vol 21 ◽  
pp. S154-S155
Author(s):  
R.A. Desai ◽  
F. Camacho ◽  
X. Tan ◽  
V. LeBaron ◽  
L. Blackhall ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Mental Health ◽  
Cancer Survivors ◽  
Breast Cancer Survivors ◽  
Elevated Risk ◽  
Opioid Use ◽  
Health Comorbidities

Towards evidence-based follow-up intervals for breast cancer survivors: Estimates of the preclinical detectable phase of contralateral second breast cancer

The Breast ◽  
2019 ◽  
Vol 45 ◽  
pp. 70-74
Author(s):  
A.M.W.M. Aarts ◽  
S.W. Duffy ◽  
S.M.E. Geurts ◽  
D.P. Vulkan ◽  
N. Houssami ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Survivors ◽  
Breast Cancer Survivors ◽  
Evidence Based ◽  
Second Breast Cancer

Pregnancy ‘Safe’ for Breast Cancer Survivors

2010 ◽  
Vol 43 (7) ◽  
pp. 17
Author(s):  
SARA FREEMAN
Keyword(s):  
Breast Cancer ◽  
Cancer Survivors ◽  
Breast Cancer Survivors

Healthcare, Perceived Discrimination, and Culture in Minority Breast Cancer Survivors

2010 ◽  
Author(s):  
Delia Sonia Saenz ◽  
Maureen Campesino ◽  
Ester Ruiz
Keyword(s):  
Breast Cancer ◽  
Cancer Survivors ◽  
Breast Cancer Survivors ◽  
Perceived Discrimination

Inflammatory mediators, exercise, and fatigue in breast cancer survivors: Pilot randomized trial

2013 ◽  
Author(s):  
Laura Q. Rogers ◽  
R. Trammell ◽  
S. Vicari ◽  
P. Hopkins-Price ◽  
A. Spenner ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Survivors ◽  
Randomized Trial ◽  
Inflammatory Mediators ◽  
Breast Cancer Survivors

Physical activity, strength and weight management in breast cancer survivors

2013 ◽  
Author(s):  
Shannon L. Mihalko ◽  
Samantha E. Yocke ◽  
Greg Russell ◽  
Marissa Howard-McNatt ◽  
Edward A. Levine
Keyword(s):  
Breast Cancer ◽  
Physical Activity ◽  
Cancer Survivors ◽  
Weight Management ◽  
Breast Cancer Survivors

Family issues in breast cancer survivors with persistent fatigue

2010 ◽  
Author(s):  
Julianne Oktay ◽  
Melissa Bellin ◽  
Susan Scarvalone ◽  
Susan Appling ◽  
Ryan MacDonald ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Survivors ◽  
Breast Cancer Survivors ◽  
Family Issues ◽  
Persistent Fatigue
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