scholarly journals The Association Between Central Nervous System‐Active Medication Use and Fall‐Related Injury in Community‐Dwelling Older Adults with Dementia

2019 ◽  
Vol 39 (5) ◽  
pp. 530-543 ◽  
Author(s):  
Laura A. Hart ◽  
Zachary A. Marcum ◽  
Shelly L. Gray ◽  
Rod L. Walker ◽  
Paul K. Crane ◽  
...  
Keyword(s):  
Older Adults ◽  
Central Nervous System ◽  
Nervous System ◽  
Medication Use ◽  
Community Dwelling ◽  
Active Medication ◽  
Community Dwelling Older Adults

scholarly journals Association Between Medications Acting on the Central Nervous System and Fall-Related Injuries in Community-Dwelling Older Adults: A New User Cohort Study

2019 ◽  
Vol 75 (5) ◽  
pp. 1003-1009 ◽  
Author(s):  
Shelly L Gray ◽  
Zachary A Marcum ◽  
Sascha Dublin ◽  
Rod Walker ◽  
Negar Golchin ◽  
...  
Keyword(s):  
Older Adults ◽  
Central Nervous System ◽  
Nervous System ◽  
Injury Risk ◽  
Cox Proportional Hazards ◽  
Community Dwelling ◽  
Active Medication ◽  
Increased Risk ◽  
The Central Nervous System ◽  
Community Dwelling Older Adults

Abstract Background It is well established that individual medications that affect the central nervous system (CNS) increase falls risk in older adults. However, less is known about risks associated with taking multiple CNS-active medications. Methods Employing a new user design, we used data from the Adult Changes in Thought study, a prospective cohort of community-dwelling people aged 65 and older without dementia. We created a time-varying composite measure of CNS-active medication exposure from electronic pharmacy fill data and categorized into mutually exclusive categories: current (within prior 30 days), recent (31–90 days), past (91–365 days), or nonuse (no exposure in prior year). We calculated standardized daily dose and identified new initiation. Cox proportional hazards models examined the associations between exposures and the outcome of fall-related injury identified from health plan electronic databases. Results Two thousand five hundred ninety-five people had 624 fall-related injuries over 15,531 person-years of follow-up. Relative to nonuse, fall-related injury risk was significantly greater for current use of CNS-active medication (hazard ratio [HR] = 1.95; 95% CI = 1.57–2.42), but not for recent or past use. Among current users, increased risk was noted with all doses. Risk was increased for new initiation compared with no current use (HR = 2.81; 95% CI = 2.09–3.78). Post hoc analyses revealed that risk was especially elevated with new initiation of opioids. Conclusions We found that current use, especially new initiation, of CNS-active medications was associated with fall-related injury in community-dwelling older adults. Increased risk was noted with all dose categories. Risk was particularly increased with new initiation of opioids.

EVALUATING THE ASSOCIATION BETWEEN CENTRAL NERVOUS SYSTEM (CNS)-ACTIVE MEDICATION USE AND FALL-RELATED INJURIES IN OLDER ADULTS WITH DEMENTIA

2017 ◽  
Vol 13 (7) ◽  
pp. P1564-P1565
Author(s):  
Laura A. Hart ◽  
Zachary Marcum ◽  
Shelly L. Gray ◽  
Rod L. Walker ◽  
Paul K. Crane ◽  
...  
Keyword(s):  
Older Adults ◽  
Central Nervous System ◽  
Nervous System ◽  
Medication Use ◽  
Active Medication

Change in central nervous system‐active medication use following fall‐related injury in older adults

2021 ◽  
Author(s):  
Laura A. Hart ◽  
Rod Walker ◽  
Elizabeth A. Phelan ◽  
Zachary A. Marcum ◽  
Naomi R. M. Schwartz ◽  
...  
Keyword(s):  
Older Adults ◽  
Central Nervous System ◽  
Nervous System ◽  
Medication Use ◽  
Active Medication

Polypharmacy and pattern of medication use in community‐dwelling older adults: A systematic review

2020 ◽  
Author(s):  
Hui‐Fen Hsu ◽  
Kuei‐Min Chen ◽  
Frank Belcastro ◽  
Yih‐Fung Chen
Keyword(s):  
Systematic Review ◽  
Older Adults ◽  
Medication Use ◽  
Community Dwelling ◽  
Community Dwelling Older Adults

scholarly journals Determinants of Potentially Inappropriate Medication Use among Community-Dwelling Older Adults

2016 ◽  
Vol 52 (4) ◽  
pp. 1534-1549 ◽  
Author(s):  
G. Edward Miller ◽  
Eric M. Sarpong ◽  
Amy J. Davidoff ◽  
Eunice Y. Yang ◽  
Nicole J. Brandt ◽  
...  
Keyword(s):  
Older Adults ◽  
Inappropriate Medication ◽  
Medication Use ◽  
Community Dwelling ◽  
Potentially Inappropriate Medication ◽  
Inappropriate Medication Use ◽  
Community Dwelling Older Adults
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