Subcellular proteomic analysis of host-pathogen interactions using human monocytes exposed toYersinia pestis andYersinia pseudotuberculosis

PROTEOMICS ◽  
2005 ◽  
Vol 5 (7) ◽  
pp. 1877-1888 ◽  
Author(s):  
Celia G. Zhang ◽  
Arlene D. Gonzales ◽  
Megan W. Choi ◽  
Brett A. Chromy ◽  
J. Patrick Fitch ◽  
...  
Keyword(s):  
Proteomic Analysis ◽  
Human Monocytes ◽  
Host Pathogen Interactions ◽  
Host Pathogen

scholarly journals Quantitative proteomic analysis of host—pathogen interactions: a study of Acinetobacter baumannii responses to host airways

BMC Genomics ◽  
2015 ◽  
Vol 16 (1) ◽  
Author(s):  
Jose Antonio Méndez ◽  
Jesús Mateos ◽  
Alejandro Beceiro ◽  
María Lopez ◽  
María Tomás ◽  
...  
Keyword(s):  
Acinetobacter Baumannii ◽  
Proteomic Analysis ◽  
Host Pathogen Interactions ◽  
Quantitative Proteomic Analysis ◽  
Host Pathogen

scholarly journals Proteomics in Vaccinology and Immunobiology: An Informatics Perspective of the Immunone

2003 ◽  
Vol 2003 (5) ◽  
pp. 267-290 ◽  
Author(s):  
Irini A. Doytchinova ◽  
Paul Taylor
Keyword(s):  
Subcellular Localization ◽  
Data Management ◽  
Proteomic Analysis ◽  
Quantitative Methods ◽  
Host Pathogen Interactions ◽  
Subunit Vaccines ◽  
Host Pathogen ◽  
Experimental Process ◽  
The Impact

The postgenomic era, as manifest, inter alia, by proteomics, offers unparalleled opportunities for the efficient discovery of safe, efficacious, and novel subunit vaccines targeting a tranche of modern major diseases. A negative corollary of this opportunity is the risk of becoming overwhelmed by this embarrassment of riches. Informatics techniques, working to address issues of both data management and through prediction to shortcut the experimental process, can be of enormous benefit in leveraging the proteomic revolution. In this disquisition, we evaluate proteomic approaches to the discovery of subunit vaccines, focussing on viral, bacterial, fungal, and parasite systems. We also adumbrate the impact that proteomic analysis of host-pathogen interactions can have. Finally, we review relevant methods to the prediction of immunome, with special emphasis on quantitative methods, and the subcellular localization of proteins within bacteria.

Spatiotemporal Structure of Host-Pathogen Interactions in a Metapopulation

2009 ◽  
Vol 174 (3) ◽  
pp. 308
Author(s):  
Soubeyrand ◽  
Laine ◽  
Hanski ◽  
Penttinen
Keyword(s):  
Host Pathogen Interactions ◽  
Spatiotemporal Structure ◽  
Host Pathogen

scholarly journals Porcine small intestinal organoids as a model to explore ETEC–host interactions in the gut

2021 ◽  
Vol 52 (1) ◽  
Author(s):  
Bjarne Vermeire ◽  
Liara M. Gonzalez ◽  
Robert J. J. Jansens ◽  
Eric Cox ◽  
Bert Devriendt
Keyword(s):  
Intestinal Epithelial ◽  
Gut Health ◽  
Functional Responses ◽  
Host Pathogen Interactions ◽  
Epithelial Surface ◽  
Host Interactions ◽  
Intestinal Organoids ◽  
Host Pathogen ◽  
Small Intestinal

AbstractSmall intestinal organoids, or enteroids, represent a valuable model to study host–pathogen interactions at the intestinal epithelial surface. Much research has been done on murine and human enteroids, however only a handful studies evaluated the development of enteroids in other species. Porcine enteroid cultures have been described, but little is known about their functional responses to specific pathogens or their associated virulence factors. Here, we report that porcine enteroids respond in a similar manner as in vivo gut tissues to enterotoxins derived from enterotoxigenic Escherichia coli, an enteric pathogen causing postweaning diarrhoea in piglets. Upon enterotoxin stimulation, these enteroids not only display a dysregulated electrolyte and water balance as shown by their swelling, but also secrete inflammation markers. Porcine enteroids grown as a 2D-monolayer supported the adhesion of an F4+ ETEC strain. Hence, these enteroids closely mimic in vivo intestinal epithelial responses to gut pathogens and are a promising model to study host–pathogen interactions in the pig gut. Insights obtained with this model might accelerate the design of veterinary therapeutics aimed at improving gut health.

scholarly journals Movement can mediate temporal mismatches between resource availability and biological events in host–pathogen interactions

2021 ◽  
Author(s):  
Tobias Kürschner ◽  
Cédric Scherer ◽  
Viktoriia Radchuk ◽  
Niels Blaum ◽  
Stephanie Kramer‐Schadt
Keyword(s):  
Resource Availability ◽  
Host Pathogen Interactions ◽  
Host Pathogen

Convergent evolution and mimicry of protein linear motifs in host–pathogen interactions

2015 ◽  
Vol 32 ◽  
pp. 91-101 ◽  
Author(s):  
Lucía Beatriz Chemes ◽  
Gonzalo de Prat-Gay ◽  
Ignacio Enrique Sánchez
Keyword(s):  
Convergent Evolution ◽  
Host Pathogen Interactions ◽  
Host Pathogen ◽  
Linear Motifs
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