Peak weight velocity in infancy is negatively associated with lung function in adolescence

BackgroundInfant weight gain is associated with lower lung function and a higher risk of childhood asthma. Detailed individual childhood growth patterns might be better predictors of childhood respiratory morbidity than the difference between two weight and height measurements. We assessed the associations of early childhood growth patterns with lung function and asthma at the age of 10 years and whether the child’s current body mass index (BMI) influenced any association.MethodsWe derived peak height and weight growth velocity, BMI at adiposity peak, and age at adiposity peak from longitudinally measured weight and height data in the first 3 years of life of 4435 children enrolled in a population-based prospective cohort study. At 10 years of age, spirometry was performed and current asthma was assessed by questionnaire. Spirometry outcomes included forced vital capacity (FVC), forced expiratory volume in 1 s (FEV1), FEV1/FVC ratio, and forced expiratory flow after exhaling 75% of vital capacity (FEF75).ResultsGreater peak weight velocity was associated with higher FVC but lower FEV1/FVC and FEF75. Greater BMI at adiposity peak was associated with higher FVC and FEV1 but lower FEV1/FVC and FEF75. Greater age at adiposity peak was associated with higher FVC, FEV1, FEV1/FVC and FEF75, particularly in children with a small size at birth, and lower odds of current asthma in boys. The child’s current BMI only explained the associations of peak weight velocity and BMI at adiposity peak with FVC and FEV1. Peak height velocity was not consistently associated with impaired lung function or asthma.ConclusionPeak weight velocity and BMI at adiposity peak were associated with reduced airway patency in relation to lung volume, whereas age at adiposity peak was associated with higher lung function parameters and lower risk of asthma at 10 years, particularly in boys.

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Lifetime exposure to particulate air pollutants is negatively associated with lung function in non-asthmatic children

Environmental Pollution ◽

10.1016/j.envpol.2017.10.092 ◽

2018 ◽

Vol 236 ◽

pp. 953-961 ◽

Cited By ~ 10

Author(s):

Hung-Chang Tsui ◽

Chi-Hsien Chen ◽

Ying-Hsuan Wu ◽

Hung-Che Chiang ◽

Bing-Yu Chen ◽

...

Keyword(s):

Lung Function ◽

Air Pollutants ◽

Negatively Associated ◽

Asthmatic Children ◽

Lifetime Exposure

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Variation in Sequences of Age a t Peak Height Velocity and Age at Peak Weight Velocity

The Journal of Anthropological Society of Nippon ◽

10.1537/ase1911.97.189 ◽

1989 ◽

Vol 97 (2) ◽

pp. 189-189 ◽

Cited By ~ 2

Author(s):

Takashi SATAKE ◽

Fumio KIKUTA ◽

Tadashi OZAKI

Keyword(s):

Peak Height ◽

Height Velocity ◽

Peak Height Velocity ◽

Peak Weight ◽

Weight Velocity

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Onset of Puberty in MZ and DZ Twins

Acta geneticae medicae et gemellologiae ◽

10.1017/s0001566000009946 ◽

1977 ◽

Vol 26 (2) ◽

pp. 151-157 ◽

Cited By ~ 51

Author(s):

Siv Fischbein

Keyword(s):

Twin Study ◽

Genetic Factors ◽

Genetic Regulation ◽

Peak Height ◽

Sex Characteristics ◽

Age At Menarche ◽

Secondary Sex Characteristics ◽

Maximal Height ◽

Peak Weight ◽

Weight Velocity

A twin study on the significance of genetic factors for the variation in peak height and peak weight velocity, as well as in age at menarche and the development of secondary sex characteristics, is presented. Evidence of a rather strong genetic regulation of the occurrence of puberty was obtained in the analysis. The maximal height or weight gain (in cm/year or kg/year) seems to be, at least in girls, less influenced by genetic factors than the age at which it appears.

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Routine Pulmonary Function Test Can Estimate the Extent of Tuberculous Destroyed Lung

The Scientific World JOURNAL ◽

10.1100/2012/835031 ◽

2012 ◽

Vol 2012 ◽

pp. 1-5 ◽

Cited By ~ 1

Author(s):

Eun Joo Lee ◽

Sang Yeub Lee ◽

Kwang Ho In ◽

Se Hwa Yoo ◽

Eun Jeong Choi ◽

...

Keyword(s):

Lung Function ◽

Pulmonary Function ◽

Scoring System ◽

Past History ◽

Chest Ct ◽

Respiratory Impairment ◽

Negatively Associated ◽

Entire Lung ◽

History Of ◽

Destroyed Lung

Tuberculous destroyed lung (TDL) is diagnosed by a clear past history of tuberculosis with findings of parenchymal destruction verified by chest X-ray. Despite the resultant deterioration of lung function and quality of lives seen in TDL patients, the exact mechanism or characteristics of pulmonary function worsening have not been clearly studied. We investigated the feature of respiratory impairment of TDL patients, and studied whether extent of destroyed lung measured with chest CT has any correlation with routine lung function. To evaluate the degree of destruction, the Goddard classification scoring system was modified into a novel scoring system (destroyed lung score, (DLS)) with a score from 0 to 4. Twenty-five subjects were enrolled. TDL predominantly manifested as an obstructive pattern (64%, 16/25). Median value of DLS of the entire lung was 2.6 (1.7–3.9). Absolute values of FEV1 and FVC were both negatively associated with DLS (r=-0.78,P=0.001, andr=-0.61,P=0.021). Percentage of predicted value of FEV1and FVC were also negatively associated with DLS (r=-0.62,P=0.019, andr=-0.76,P=0.002). Our study shows that lung function of TDL patients were notably correlated with the extent of destroyed lung measured with chest CT scan.

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No effect of artificial gravity on lung function with exercise training during head-down bed rest

International Journal of Astrobiology ◽

10.1017/s1473550415000294 ◽

2015 ◽

pp. 1-7

Author(s):

Longxiang Su ◽

Yinghua Guo ◽

Yajuan Wang ◽

Delong Wang ◽

Changting Liu

Keyword(s):

Lung Function ◽

Pulse Rate ◽

Vital Capacity ◽

Pulmonary Ventilation ◽

Bed Rest ◽

Forced Expiratory Volume ◽

Observation Time ◽

Artificial Gravity ◽

Postural Changes ◽

Expiratory Flow

AbstractTo explore the effectiveness of microgravity simulated by head-down bed rest (HDBR) and artificial gravity (AG) with exercise on lung function. Twenty-four volunteers were randomly divided into control and exercise countermeasure (CM) groups for 96 h of 6° HDBR. Comparisons of pulse rate, pulse oxygen saturation (SpO2) and lung function were made between these two groups at 0, 24, 48, 72, 96 h. Compared with the sitting position, inspiratory capacity and respiratory reserve volume were significantly higher than before HDBR (0° position) (P< 0.05). Vital capacity, expiratory reserve volume, forced vital capacity, forced expiratory volume in 1 s, forced inspiratory vital capacity, forced inspiratory volume in 1 s, forced expiratory flow at 25, 50 and 75%, maximal mid-expiratory flow and peak expiratory flow were all significantly lower than those before HDBR (P< 0.05). Neither control nor CM groups showed significant differences in the pulse rate, SpO2, pulmonary volume and pulmonary ventilation function over the HDBR observation time. Postural changes can lead to variation in lung volume and ventilation function, but a HDBR model induced no changes in pulmonary function and therefore should not be used to study AG CMs.

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