Corticosteroids in the prevention and treatment of infants with bronchopulmonary dysplasia: Part I. Systemic corticosteroids

2021 ◽  
Author(s):  
Hajnalka Szabó ◽  
Eugenio Baraldi ◽  
Andrew A. Colin
Keyword(s):  
Bronchopulmonary Dysplasia ◽  
Systemic Corticosteroids ◽  
Prevention And Treatment

scholarly journals Searching for better animal models of BPD: a perspective

2016 ◽  
Vol 311 (5) ◽  
pp. L924-L927 ◽  
Author(s):  
Namasivayam Ambalavanan ◽  
Rory E. Morty
Keyword(s):  
Animal Models ◽  
Bronchopulmonary Dysplasia ◽  
Prevention And Treatment

There have been many efforts to develop good animal models of bronchopulmonary dysplasia (BPD) to better understand the pathophysiology and mechanisms underlying development of BPD as well as to test potential strategies for its prevention and treatment. This Perspectives summarizes the features of common animal models of BPD and the strengths and limitations of such models. Potential optimal approaches to development of animal models are indicated, with the underlying concepts that require emphasis.

scholarly journals Respiratory Tract Microecology and Bronchopulmonary Dysplasia in Preterm Infants

2021 ◽  
Vol 9 ◽  
Author(s):  
Tong Sun ◽  
Haiyang Yu ◽  
Jianhua Fu
Keyword(s):  
Respiratory Tract ◽  
Microbial Diversity ◽  
Preterm Infants ◽  
Bronchopulmonary Dysplasia ◽  
Premature Infants ◽  
Respiratory Complication ◽  
Prevention And Treatment ◽  
New Ideas

Bronchopulmonary dysplasia (BPD) is a severe respiratory complication in preterm infants. Although the etiology and pathogenesis of BPD are complex and remain to be clarified, recent studies have reported a certain correlation between the microecological environment of the respiratory tract and BPD. Changes in respiratory tract microecology, such as abnormal microbial diversity and altered evolutional patterns, are observed prior to the development of BPD in premature infants. Therefore, research on the colonization and evolution of neonatal respiratory tract microecology and its relationship with BPD is expected to provide new ideas for its prevention and treatment. In this paper, we review microecological changes in the respiratory tract and the mechanisms by which they can lead to BPD in preterm infants.

scholarly journals Survey of the Use of Corticosteroids Among Neonatal Intensive Care Units for the Prevention or Treatment of Bronchopulmonary Dysplasia

2005 ◽  
Vol 10 (2) ◽  
pp. 90-99
Author(s):  
Kalen B. Porter ◽  
Sandra S. Garner
Keyword(s):  
Intensive Care ◽  
Intensive Care Units ◽  
Bronchopulmonary Dysplasia ◽  
Neonatal Intensive Care ◽  
Inhaled Corticosteroids ◽  
Academic Medical Centers ◽  
Neonatal Intensive Care Units ◽  
Medical Centers ◽  
Systemic Corticosteroids ◽  
Academic Medical

OBJECTIVE To survey neonatal intensive care units (NICUs) at academic medical centers to determine the current use of inhaled and systemic corticosteroids for the prevention or treatment of bronchopulmonary dysplasia (BPD). METHODS A survey was developed to evaluate aspects of systemic and inhaled corticosteroid use in neonates. Eighty academic medical centers with neonatal/perinatal medicine fellowship programs were surveyed. Neonatology fellows or NICU clinical pharmacists with direct patient care activities responded via telephone, fax or e-mail. RESULTS Fifty-three institutions responded to the survey (66.3% response rate). Twenty-nine percent of respondents (n = 15) use corticosteroids for prevention of BPD. Systemic corticosteroids are used by 6% of respondents (n = 3) and inhaled corticosteroids are used by 14% of respondents (n = 7) for prevention. Ten percent of respondents (n = 5) use either systemic or inhaled corticosteroids for prevention. Eighty-eight percent of respondents (n = 45) use corticosteroids for treatment of BPD. Systemic corticosteroids are used by 10% of respondents (n = 5) and inhaled corticosteroids are used by 10% of respondents (n = 5) for treatment. Sixty-nine percent of respondents (n = 35) use either systemic or inhaled corticosteroids for treatment. There was a wide variability in drug, dose, titration, taper, administration, and duration of therapy reported. CONCLUSIONS These results indicate that systemic and inhaled corticosteroids are commonly used by practitioners for the prevention or treatment of BPD despite a recommendation against the routine use of systemic corticosteroids by the American Academy of Pediatrics' (AAP) Committee on Fetus and Newborn and the Canadian Paediatric Society's Fetus and Newborn Committee from February 2002.

scholarly journals Proteins in cord blood as a new target for prevention and treatment of bronchopulmonary dysplasia: a proteomic analysis

2021 ◽  
Author(s):  
Juan Wang ◽  
Jianping Mao ◽  
Gang Chen ◽  
Yuanmei Huang ◽  
Jinjin Zhou ◽  
...  
Keyword(s):  
Cord Blood ◽  
Signaling Pathways ◽  
Signaling Pathway ◽  
Bronchopulmonary Dysplasia ◽  
Proteomic Analysis ◽  
Mapk Signaling ◽  
Term Infants ◽  
Reproductive Process ◽  
Prevention And Treatment ◽  
Differential Proteins

Abstract This study aimed to explore the proteins in cord blood that could regulate the development of neonatal bronchi and lungs, and to find a new target for the prevention and treatment of bronchopulmonary dysplasia (BPD). In this study, proteomic analysis was used to analyze the proteins in cord blood of preterm and term infants. A total of 100 differentially expressed (57 up-regulated and 43 down-regulated) proteins were identified from preterm with BPD and term infants cord blood (fold change ≥ 1.5, P value < 0.05). GO analysis revealed that the major enrichment functions of these differential proteins were multi-organism process, stimulus, immune system process growth, reproductive process, development process and antioxidant activity. The signaling pathways involved included insulin resistance, insulin signaling pathway, IL−17 signaling pathway, PI3K−Akt signaling pathway, NF−kappa B signaling pathway, glucagon signaling pathway, apoptosis, MAPK signaling pathway, as well as glycolysis/gluconeogenesis. Further protein and protein interact (PPI) analysis revealed that the interacting proteins involved were PGAM1, CNN2, HSP90AA and DAG1, which were all crucial in the development of BPD. We found that these differential proteins in cord blood might regulate bronchopulmonary development through the abovementioned signaling pathways or their interaction proteins, which may provide a new research direction for the intervention of BPD.

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