Drug binding and resistance mechanism of KIT tyrosine kinase revealed by hydrogen/deuterium exchange FTICR mass spectrometry

Protein Science ◽

10.1002/pro.347 ◽

2010 ◽

Vol 19 (4) ◽

pp. 703-715 ◽

Author(s):

Hui-Min Zhang ◽

Xiu Yu ◽

Michael J. Greig ◽

Ketan S. Gajiwala ◽

Joe C. Wu ◽

...

Keyword(s):

Mass Spectrometry ◽

Tyrosine Kinase ◽

Resistance Mechanism ◽

Deuterium Exchange ◽

Drug Binding ◽

Hydrogen Deuterium Exchange ◽

Fticr Mass Spectrometry ◽

Hydrogen Deuterium

Download Full-text

Detection of structural and conformational changes in ALS-causing mutant profilin-1 with hydrogen/deuterium exchange mass spectrometry and bioinformatics techniques

Metabolic Brain Disease ◽

10.1007/s11011-021-00763-y ◽

2021 ◽

Author(s):

Ahmad Shahir Sadr ◽

Zahra Abdollahpour ◽

Atousa Aliahmadi ◽

Changiz Eslahchi ◽

Mina Nekouei ◽

...

Keyword(s):

Mass Spectrometry ◽

Conformational Changes ◽

Deuterium Exchange ◽

Hydrogen Deuterium Exchange ◽

Exchange Mass Spectrometry ◽

Hydrogen Deuterium ◽

Deuterium Exchange Mass Spectrometry

Download Full-text

A simple method for differentiation of monoisotopic drug metabolites with hydrogen–deuterium exchange liquid chromatography/electrospray mass spectrometry

European Journal of Pharmaceutical Sciences ◽

10.1016/j.ejps.2005.02.005 ◽

2005 ◽

Vol 25 (1) ◽

pp. 155-162 ◽

Author(s):

Ari Tolonen ◽

Miia Turpeinen ◽

Jouko Uusitalo ◽

Olavi Pelkonen

Keyword(s):

Mass Spectrometry ◽

Liquid Chromatography ◽

Electrospray Mass Spectrometry ◽

Deuterium Exchange ◽

Hydrogen Deuterium Exchange ◽

Simple Method ◽

Drug Metabolites ◽

Hydrogen Deuterium

Download Full-text

Design and Validation of In-Source Atmospheric Pressure Photoionization Hydrogen/Deuterium Exchange Mass Spectrometry with Continuous Feeding of D2O

Journal of the American Society for Mass Spectrometry ◽

10.1007/s13361-017-1831-8 ◽

2017 ◽

Vol 29 (1) ◽

pp. 85-94 ◽

Author(s):

Thamina Acter ◽

Seulgidaun Lee ◽

Eunji Cho ◽

Maeng-Joon Jung ◽

Sunghwan Kim

Keyword(s):

Mass Spectrometry ◽

Atmospheric Pressure ◽

Deuterium Exchange ◽

Hydrogen Deuterium Exchange ◽

Atmospheric Pressure Photoionization ◽

Exchange Mass Spectrometry ◽

Hydrogen Deuterium ◽

Deuterium Exchange Mass Spectrometry ◽

Continuous Feeding

Download Full-text

Different conformational dynamics of various active states of β-arrestin1 analyzed by hydrogen/deuterium exchange mass spectrometry

Journal of Structural Biology ◽

10.1016/j.jsb.2015.04.006 ◽

2015 ◽

Vol 190 (2) ◽

pp. 250-259 ◽

Author(s):

Dong Kyun Kim ◽

Youngjoo Yun ◽

Hee Ryung Kim ◽

Min-Duk Seo ◽

Ka Young Chung

Keyword(s):

Mass Spectrometry ◽

Conformational Dynamics ◽

Deuterium Exchange ◽

Hydrogen Deuterium Exchange ◽

Exchange Mass Spectrometry ◽

Hydrogen Deuterium ◽

Deuterium Exchange Mass Spectrometry

Download Full-text

Hydrogen deuterium exchange mass spectrometry in biopharmaceutical discovery and development – A review

Analytica Chimica Acta ◽

10.1016/j.aca.2016.08.006 ◽

2016 ◽

Vol 940 ◽

pp. 8-20 ◽

Author(s):

Bin Deng ◽

Cristina Lento ◽

Derek J. Wilson

Keyword(s):

Mass Spectrometry ◽

Deuterium Exchange ◽

Hydrogen Deuterium Exchange ◽

Exchange Mass Spectrometry ◽

Hydrogen Deuterium ◽

Deuterium Exchange Mass Spectrometry

Download Full-text

Hydrogen-Deuterium Exchange Mass Spectrometry of Phosphorylation Induced Changes in Smooth Muscle Myosin

Biophysical Journal ◽

10.1016/j.bpj.2012.11.2501 ◽

2013 ◽

Vol 104 (2) ◽

pp. 452a

Author(s):

K. Ilker Sen ◽

Brian D. Haldeman ◽

Richard Brizendine ◽

Roger Mercer ◽

Christine R. Cremo ◽

...

Keyword(s):

Mass Spectrometry ◽

Smooth Muscle ◽

Smooth Muscle Myosin ◽

Deuterium Exchange ◽

Hydrogen Deuterium Exchange ◽

Exchange Mass Spectrometry ◽

Hydrogen Deuterium ◽

Deuterium Exchange Mass Spectrometry ◽

Induced Changes ◽

Download Full-text

Deglycosylation induces extensive dynamics changes in α-amylase revealed by hydrogen/deuterium exchange mass spectrometry

Rapid Communications in Mass Spectrometry ◽

10.1002/rcm.6732 ◽

2013 ◽

Vol 27 (23) ◽

pp. 2625-2630 ◽

Author(s):

Chengjie Ji ◽

Gary Wei

Keyword(s):

Mass Spectrometry ◽

Deuterium Exchange ◽

Hydrogen Deuterium Exchange ◽

Exchange Mass Spectrometry ◽

Hydrogen Deuterium ◽

Deuterium Exchange Mass Spectrometry

Download Full-text

Research advances in hydrogen–deuterium exchange mass spectrometry for protein epitope mapping

Analytical and Bioanalytical Chemistry ◽

10.1007/s00216-020-03091-9 ◽

2021 ◽

Author(s):

Haofeng Sun ◽

Lingyun Ma ◽

Leyu Wang ◽

Peng Xiao ◽

Hongmei Li ◽

...

Keyword(s):

Mass Spectrometry ◽

Epitope Mapping ◽

Deuterium Exchange ◽

Hydrogen Deuterium Exchange ◽

Exchange Mass Spectrometry ◽

Hydrogen Deuterium ◽

Deuterium Exchange Mass Spectrometry

Download Full-text

Moderated Test Statistics to Detect Differential Deuteration in Hydrogen/Deuterium Exchange Mass Spectrometry Experiments

Analytical Chemistry ◽

10.1021/acs.analchem.1c02346 ◽

2021 ◽

Author(s):

Jürgen Claesen ◽

Srinath Krishnamurthy ◽

Andy M. Lau ◽

Anastassios Economou

Keyword(s):

Mass Spectrometry ◽

Deuterium Exchange ◽

Hydrogen Deuterium Exchange ◽

Test Statistics ◽

Exchange Mass Spectrometry ◽

Hydrogen Deuterium ◽

Deuterium Exchange Mass Spectrometry

Download Full-text

Cover Picture: Identification of Pharmacological Chaperones for Gaucher Disease and Characterization of Their Effects on β-Glucocerebrosidase by Hydrogen/Deuterium Exchange Mass Spectrometry (ChemBioChem 16/2008)

ChemBioChem ◽

10.1002/cbic.200890061 ◽

2008 ◽

Vol 9 (16) ◽

pp. 2549-2549

Author(s):

Michael B. Tropak ◽

Gregory J. Kornhaber ◽

Brigitte A. Rigat ◽

Gustavo H. Maegawa ◽

Justin D. Buttner ◽

...

Keyword(s):

Mass Spectrometry ◽

Gaucher Disease ◽

Deuterium Exchange ◽

Hydrogen Deuterium Exchange ◽

Pharmacological Chaperones ◽

Exchange Mass Spectrometry ◽

Hydrogen Deuterium ◽

Deuterium Exchange Mass Spectrometry ◽

Picture Identification

Download Full-text