scholarly journals hZIP1 zinc transporter down-regulation in prostate cancer involves the overexpression of ras responsive element binding protein-1 (RREB-1)

The Prostate ◽  
2011 ◽  
Vol 71 (14) ◽  
pp. 1518-1524 ◽  
Author(s):  
Jing Zou ◽  
Beatrice C. Milon ◽  
Mohamed M. Desouki ◽  
Leslie C. Costello ◽  
Renty B. Franklin
Keyword(s):  
Prostate Cancer ◽  
Binding Protein ◽  
Zinc Transporter ◽  
Down Regulation ◽  
Element Binding Protein ◽  
Responsive Element

scholarly journals Iron-responsive element-binding protein 2 plays an essential role in regulating prostate cancer cell growth

Oncotarget ◽  
2017 ◽  
Vol 8 (47) ◽  
pp. 82231-82243 ◽  
Author(s):  
Zhiyong Deng ◽  
David H. Manz ◽  
Suzy V. Torti ◽  
Frank M. Torti
Keyword(s):  
Prostate Cancer ◽  
Cell Growth ◽  
Cancer Cell ◽  
Essential Role ◽  
Prostate Cancer Cell ◽  
Binding Protein ◽  
Cancer Cell Growth ◽  
Iron Responsive Element ◽  
Element Binding Protein ◽  
Responsive Element

scholarly journals Ras responsive element binding protein-1 (RREB-1) down-regulates hZIP1 expression in prostate cancer cells

The Prostate ◽  
2009 ◽  
Vol 70 (3) ◽  
pp. 288-296 ◽  
Author(s):  
Beatrice C. Milon ◽  
Anthony Agyapong ◽  
Roderick Bautista ◽  
Leslie C. Costello ◽  
Renty B. Franklin
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Binding Protein ◽  
Prostate Cancer Cells ◽  
Element Binding Protein ◽  
Responsive Element

Exploring the Role of Asp1116 in Selective Drug Targeting of CREBcAMP- Responsive Element-binding Protein Implicated in Prostate Cancer

2020 ◽  
Vol 23 (3) ◽  
pp. 178-184
Author(s):  
Oluwayimika E. Akinsiku ◽  
Opeyemi S. Soremekun ◽  
Fisayo A. Olotu ◽  
Mahmoud E.S. Soliman
Keyword(s):  
Prostate Cancer ◽  
Active Site ◽  
Binding Protein ◽  
Therapeutic Option ◽  
Dynamics Simulation ◽  
Strong Hydrogen Bond ◽  
Hydrogen Bond Interaction ◽  
Selective Targeting ◽  
Element Binding Protein ◽  
Responsive Element

Background: The selective targeting of CREB-cAMP-responsive element-binding protein (CBP) has recently evolved as a vital therapeutic approach for curtailing its aberrant upregulation associated with the development of prostate cancer. Inhibition of CBP has been discovered to be an important therapeutic option in androgen receptor signalling pathway mediated prostate cancer. Y08197, a novel selective inhibitor of CBP, has shown promising therapeutic outcome in prostate carcinogenesis over non-selective analogues such as CPI-637. Methods/Results: Herein, we used molecular dynamics simulation to gain insights into the mechanistic and selective targeting of Y08197 at the bromodomain active site. Molecular Mechanics/ Poisson-Boltzmann Surface Area (MM/PBSA) analysis revealed a similar inhibitory effect between Y08197 and CPI-637. Furthermore, in exploring the selective affinity of Y08197 towards CBP in combination with Bromodomain and PHD finger-containing protein 1(BRPF1), our findings highlighted Asp1116 as the ‘culprit’ residue responsible for this selective targeting. Upon binding, Asp1116 assumed a conformation that altered the architecture of the bromodomain active site, thereby orienting the helices around the active site in a more compacted position. In addition to some specific structural perturbations mediated by Asp1116 on the dynamics of CBP, our study revealed that the strong hydrogen bond interaction (N-H...O) elicited in CBP-Y08197 sequestered Y08197 tightly into the CBP bromodomain active site. Conclusion: Conclusively, the inhibition and selective pattern of Y08197 can be replicated in future structure-based CBP inhibitors and other bromodomain implicated in carcinogenesis.

scholarly journals The Zinc Finger Protein Ras-Responsive Element Binding Protein-1 Is a Coregulator of the Androgen Receptor: Implications for the Role of the Ras Pathway in Enhancing Androgenic Signaling in Prostate Cancer

2007 ◽  
Vol 21 (9) ◽  
pp. 2056-2070 ◽  
Author(s):  
Nishit K. Mukhopadhyay ◽  
Bekir Cinar ◽  
Lipi Mukhopadhyay ◽  
Mohini Lutchman ◽  
Angeline S. Ferdinand ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
Zinc Finger ◽  
Zinc Finger Protein ◽  
Binding Protein ◽  
Ras Pathway ◽  
Finger Protein ◽  
Element Binding Protein ◽  
Responsive Element

scholarly journals Iron-responsive element-binding protein. Phosphorylation by protein kinase C.

1993 ◽  
Vol 268 (36) ◽  
pp. 27363-27370
Author(s):  
R S Eisenstein ◽  
P T Tuazon ◽  
K L Schalinske ◽  
S A Anderson ◽  
J A Traugh
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Protein Phosphorylation ◽  
Binding Protein ◽  
Iron Responsive Element ◽  
Kinase C ◽  
Element Binding Protein ◽  
Responsive Element

scholarly journals Iron regulates the activity of the iron-responsive element binding protein without changing its rate of synthesis or degradation.

1992 ◽  
Vol 267 (34) ◽  
pp. 24466-24470 ◽  
Author(s):  
C.K. Tang ◽  
J Chin ◽  
J.B. Harford ◽  
R.D. Klausner ◽  
T.A. Rouault
Keyword(s):  
Binding Protein ◽  
Iron Responsive Element ◽  
Element Binding Protein ◽  
Responsive Element

scholarly journals Acetylation of cAMP-responsive Element-binding Protein (CREB) by CREB-binding Protein Enhances CREB-dependent Transcription

2003 ◽  
Vol 278 (18) ◽  
pp. 15727-15734 ◽  
Author(s):  
Qing Lu ◽  
Amanda E. Hutchins ◽  
Colleen M. Doyle ◽  
James R. Lundblad ◽  
Roland P. S. Kwok
Keyword(s):  
Binding Protein ◽  
Creb Binding Protein ◽  
Element Binding Protein ◽  
Responsive Element ◽  
Camp Responsive Element Binding

scholarly journals Sequence and expression of the murine iron-responsive element binding protein

1991 ◽  
Vol 19 (22) ◽  
pp. 6333-6333 ◽  
Author(s):  
Caroline C. Philpott ◽  
Tracey A. Rouault ◽  
Richard D. Klausner
Keyword(s):  
Binding Protein ◽  
Iron Responsive Element ◽  
Element Binding Protein ◽  
Responsive Element

POD-04.01: Purine-Rich Element Binding Protein Alpha Induces Cell Stress and Differentiation Pathways in Prostate Cancer Cells

Urology ◽  
2009 ◽  
Vol 74 (4) ◽  
pp. S10
Author(s):  
T. Inoue ◽  
A. Maeno ◽  
P. Kulkarni ◽  
Y. Zeng ◽  
D. Yeater ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Binding Protein ◽  
Cell Stress ◽  
Prostate Cancer Cells ◽  
Element Binding Protein ◽  
Differentiation Pathways
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